Publications by authors named "Tengteng Dai"
Background: Rostral ventrolateral medulla (RVLM) neuron hyperactivity raises sympathetic outflow, causing hypertension. MicroRNAs (miRNAs) contribute to diverse biological processes, but their influence on RVLM neuronal excitability and blood pressure (BP) remains widely unexplored.
Methods And Results: The RVLM miRNA profiles in spontaneously hypertensive rats were unveiled using RNA sequencing.
Chronic cerebral ischemia (CCI) can lead to vascular cognitive impairment, but therapeutic options are limited. Cognitive-exercise dual-task (CEDT), as a potential rehabilitation intervention, can attenuate cognitive impairment. However, the related mechanisms remain unclear.
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- Chronic cerebral ischemia (CCI) is increasingly causing vascular cognitive impairment, and dual-task interventions combining cognitive exercises have shown promise in improving cognitive performance in affected patients.
- In a rat model of CCI, dual-task interventions significantly enhanced cognitive function, leading to changes in key proteins and signaling pathways involved in cognition, particularly an increase in cAMP and PKA, along with a decrease in EphrinA3 and EphA4.
- The research suggests that the cognitive-exercise dual-task approach could be more effective than single-task methods in mitigating cognitive decline associated with CCI by inhibiting the EphrinA3/EphA4 system and activating the cAMP/PKA pathway.
Rostral ventrolateral medulla (RVLM) is thought to serve as a major vasomotor center that participates in controlling the progression of stress-induced hypertension (SIH). Circular RNAs (circRNAs) perform important functions in the regulation of diverse physiological and pathological processes. However, information concerning the functions of RVLM circRNAs on SIH remains limited.
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