The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease.

The nuclear N -methyladenosine (m A) reader YT521-B homology-domain-containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity. However, little is known about its biological functions in intestinal-resident macrophages and inflammatory bowel disease (IBD). Herein, it is demonstrated that macrophage-specific depletion or insufficiency of YTHDC1 accelerates IBD development in animal models.

High-strain sensitive zwitterionic hydrogels with swelling-resistant and controllable rehydration for sustainable wearable sensor.

The irrecoverability of mechanical strength, conductivity and other properties after dehydration, has severely restricted the practical applications of hydrogels. To address this issue, here we report a P(AA-SMA-SBMA) zwitterionic copolymer-based hydrogel with anti-swelling, high mechanical property and reusability after dehydration/hydration process by polymerization of acrylic acid (AA), octadecyl methacrylate (SMA) and sulfobetaine methacrylate (SBMA). The structures of the original hydrogels and that after dehydration/hydration cycles were characterized by SAXS, SEM, Raman, FT-IR, XRD, DSC and rheology, etc.

The characterization of two peroxiredoxin genes in Dunaliella viridis provides insights into antioxidative response to salt stress.

Peroxiredoxins (Prxs), a group of antioxidant enzymes, are an important component of the oxidative defense system and have been demonstrated to function as peroxidases, sensors of H(2)O(2)-mediated signaling and/or chaperones. In this study, a cDNA library was constructed from a halotolerant alga, Dunaliella viridis, and was used in a functional complementation screen for antioxidative genes in an oxidative sensitive yeast mutant. Two Prx genes, DvPrx1 and DvPrx2, were obtained from this screen.