The decline in tropical land carbon sink drove high atmospheric CO growth rate in 2023.

Atmospheric CO growth rate (CGR), reflecting the carbon balance between anthropogenic emissions and net uptake from land and ocean, largely determines the magnitude and speed of global warming. The CGR at Mauna Loa Baseline Observatory reached a record high in 2023. We quantified major components of the global carbon balance for 2023, by developing a framework that integrated fossil fuel CO emissions data and an atmospheric inversion from the Global ObservatioN-based system for monitoring Greenhouse GAses (GONGGA) with two artificial intelligence (AI) models derived from dynamic global vegetation models.

The Significance and Usage Strategies of Macromolecules in 3D Printed Ceramic Composites.

3D printing technology enables the creation of complex ceramic structures and enhances the efficiency of customized ceramic production. Polymers play a crucial role in 3D-printed ceramic composites due to their unique processability, yet their significance and application strategies remain underexplored. These polymers not only enable rapid and precise 3D shaping but also offer additional advantages due to their unique and adjustable physicochemical properties.

Transcription factor PbrERF114 is involved in the regulation of ethylene synthesis during pear fruit ripening.

The plant hormone ethylene is indispensable to the ripening of climacteric fruits. Although extensive studies have been conducted on ethylene signaling, the ethylene response factor (ERF)-mediated transcriptional regulation of ethylene biosynthesis in pear fruits remains to be fully elucidated. We here constructed, sequenced, and analyzed transcriptome libraries in ethephon-treated and 1-MCP-treated Cuiguan pear fruits.

A photo-modulated nitric oxide delivering hydrogel for the accelerated healing of biofilm infected chronic wounds.

Biofilm infection and impaired healing of chronic wounds are posing tremendous challenges in clinical practice. In this study, we presented a versatile antimicrobial hydrogel capable of delivering nitric oxide (NO) in a controllable manner to dissipate biofilms, eliminate microorganisms, and promote the healing of chronic wounds. This hydrogel was constructed by Schiff-base crosslinking of oxidized dextran and antimicrobial peptide ε-poly-lysine, further encapsulating photothermal nanoparticles bearing NO donor.

Integration of Hydrogels and 3D Bioprinting Technologies for Chronic Wound Healing Management.

The integration of hydrogel-based bioinks with 3D bioprinting technologies presents an innovative approach to chronic wound management, which is particularly challenging to treat because of its multifactorial nature and high risk of complications. Using precise deposition techniques, 3D bioprinting significantly alters traditional wound care paradigms by enabling the fabrication of patient-specific wound dressings that imitate natural tissue properties. Hydrogels are notably beneficial for these applications because of their abundant water content and mechanical properties, which promote cell viability and pathophysiological processes of wound healing, such as re-epithelialization and angiogenesis.

Interfacial delivery of carbon monoxide via smart titanium implant coating for enhanced soft tissue integration with switchable antibacterial and immunomodulatory properties.

Soft tissue integration around titanium (Ti) implants is weaker than that around natural teeth, compromising long-term success of Ti implants. Carbon monoxide (CO) possesses distinctive therapeutic properties, rendering it as a highly promising candidate for enhancing STI. However, achieving controlled CO generation at the STI interface remains challenging.

Subsurface A-site vacancy activates lattice oxygen in perovskite ferrites for methane anaerobic oxidation to syngas.

Tuning the oxygen activity in perovskite oxides (ABO) is promising to surmount the trade-off between activity and selectivity in redox reactions. However, this remains challenging due to the limited understanding in its activation mechanism. Herein, we propose the discovery that generating subsurface A-site cation (La) vacancy beneath surface Fe-O layer greatly improved the oxygen activity in LaFeO, rendering enhanced methane conversion that is 2.

Infection Microenvironment-Responsive Coating on Titanium Surfaces for On-Demand Release of Therapeutic Gas and Antibiotic.

Aseptic loosening and bacterial infection pose significant challenges in the clinical application of titanium (Ti) orthopedic implants, which are primarily caused by insufficient osseointegration and bacterial contamination. To address these issues, a responsive coating on Ti surface is constructed, which achieves enhanced osseointegration and infection elimination by on-demand release of therapeutic gas hydrogen sulfide (HS) and antibiotic. TiO nanotubes (TNT) are anodized on the Ti surface to enhance its bioactivity and serve as reservoirs for the antibiotic.

Exploring the Potentials of Chitin and Chitosan-Based Bioinks for 3D-Printing of Flexible Electronics: The Future of Sustainable Bioelectronics.

Chitin and chitosan-based bioink for 3D-printed flexible electronics have tremendous potential for innovation in healthcare, agriculture, the environment, and industry. This biomaterial is suitable for 3D printing because it is highly stretchable, super-flexible, affordable, ultrathin, and lightweight. Owing to its ease of use, on-demand manufacturing, accurate and regulated deposition, and versatility with flexible and soft functional materials, 3D printing has revolutionized free-form construction and end-user customization.

Skin-adhesive and self-healing diagnostic wound dressings for diabetic wound healing recording and electrophysiological signal monitoring.

Performing efficient wound management is essential for infected diabetic wounds due to the complex pathology. Flexible electronics have been recognized as one of the promising solutions for wound management. Herein, a kind of skin-adhesive and self-healing flexible bioelectronic was developed, which could be employed as a diagnostic wound dressing to record diabetic wound healing and monitor electrophysiological signals of the patients.

Expression pattern of PD-1/PD-L1 in primary liver cancer with clinical correlation.

Immunotherapy, including ICIs, has emerged as an invaluable treatment option for advanced PLC. Nevertheless, the expression patterns of PD-L1 and PD-1 in PLC remain incompletely understood. In this study, the expression pattern and clinical correlation of PD-L1 and PD-1 were analysed in 5245 PLC patients.

Establishment and Evaluation of Exosomes-Related Gene Risk Model in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a challenging disease to evaluate in terms of prognosis, requiring close attention to the prognosis of HCC patients. Exosomes have been shown to play an important role in HCC development and have significant potential in managing HCC patient prognosis, as they are detectable in patients' blood. By using small extracellular vesicular RNA, liquid biopsies can reflect the underlying physiological and pathological status of the originating cells, providing a valuable assessment of human health.

Flexible Electrodes for Brain-Computer Interface System.

Brain-computer interface (BCI) has been the subject of extensive research recently. Governments and companies have substantially invested in relevant research and applications. The restoration of communication and motor function, the treatment of psychological disorders, gaming, and other daily and therapeutic applications all benefit from BCI.

Construction of a Localized and Long-Acting CCN2 Delivery System on Percutaneous Ti Implant Surfaces for Enhanced Soft-Tissue Integration.

Soft-tissue integration (STI) plays an essential role in the long-term success of percutaneous Ti implants since it acts as a biological barrier that protects the soft and hard tissue around implants. Surface modification of Ti implants with drug-release properties to achieve soft-tissue regeneration has been proven to be effective in STI. However, the short-acting effect caused by the uncontrolled drug release of the topical delivery system limits long-term STI enhancement.

Biofilm microenvironment-responsive polymeric CO releasing micelles for enhanced amikacin efficacy.

Biofilm-associated infections (BAI) have posed serious threats to public health. Novel therapy based on carbon monoxide (CO) is being increasingly appreciated. However, CO therapy like inhaled gas treatment was impeded owing to its low bioavailability.

Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections.

Due to protection of extracellular polymeric substances, the therapeutic efficiency of conventional antimicrobial agents is often impeded by their poor infiltration and accumulation in biofilm. Herein, one type of surface charge adaptable nitric oxide (NO) nanogenerator was developed for biofilm permeation, retention and eradication. This nanogenerator (PDG@Au-NO/PBAM) is composed of a core-shell structure: thermo-sensitive NO donor conjugated AuNPs on cationic poly(dopamine--glucosamine) nanoparticle (PDG@Au-NO) served as core, and anionic phenylboronic acid-acryloylmorpholine (PBAM) copolymer was employed as a shell.

Uncovering the special microbiota associated with occurrence and progression of gastric cancer by using RNA-sequencing.

Gastric cancer (GC) has been identified as the third deadly cancer in the world. Accumulating researches suggest a potential role of microorganisms in tumorigenesis. However, the composition of microbiota in GC tissues is not clear and it changes throughout the different stages of GC remain mostly elusive.

Roxarsone Delivery Nanocomposite Based on Nitrite-Functionalized Mesoporous Polydopamine for Multidrug-Resistant Bacterial Infections via Enhanced Chemo-Photothermal Therapy.

Current treatments for infections caused by multidrug-resistant bacteria still remain challenging and therapeutic materials with high efficacy are of demand. Herein, a bactericidal nanocomposite was constructed by loading Roxarsone (ROX) onto nitrosylated mesoporous polydopamine (named mPDA@NO-ROX). The designed nanocomposite exhibited considerable photothermal effect and controlled NO and ROX co-delivery under the irradiation of near-infrared laser (NIR) to achieve enhanced chemo-photothermal antibacterial therapy.

The intelligent experience inheritance system for Traditional Chinese Medicine.

The inheritance of knowledge and experience was crucial to the development of Traditional Chinese Medicine (TCM). However, the existing methods of inheriting the unique clinical experience of famous veteran TCM doctors still followed the outdated and inefficient Master-Prentice schema. In addition, the inherited medical books and records were usually lack of standardization and systematization.

Converting lysozyme to hydrogel: A multifunctional wound dressing that is more than antibacterial.

Wounds are usually irregular in shapes, and accompanied with a series of disorders such as hemorrhage and bacteria contamination. Here, we report a multifunctional hydrogel prepared by phase-transited lysozyme (PTL), which presents antimicrobial, injectable, self-healing, tissue adhesive, hemostatic and biodegradable properties that fit the requirements of wound treatment. The lysozyme was unfolded under the action of tris(2-carboxyethyl)phosphine (TCEP), and then self-assembled into a hydrogel (PTLG).

Experimental study of impact mechanical and microstructural properties of modified carbon fiber reinforced concrete.

This paper investigated the preparation method and the dispersion behaviour of Modified Carbon Nanotube-fiber Reinforcements (MCNF), the change laws and the effect mechanisms of dynamic compressive strength of MCNF concretes. Electrophoresis method was used to prepare MCNF and its interfacial shear performance was tested by interfacial shear strength (IFSS) test. In addition, the dispersion behavior of MCNF in simulated concrete solution was verified by turbidity method.

Research on the True Triaxial Mechanical Properties of Concrete under the Coupling Action of High Temperature and Biaxial Unequal Lateral Pressure.

Based on engineering practice and practical needs, this paper takes ordinary concrete specimens as the research object, and adopts a high-temperature true triaxial loading test system to carry out high-temperature uniaxial and true triaxial static compression tests of concrete under high-temperature conditions. By comparing with normal temperature conditions, this paper analyzes the influence of the coupling effect of high-temperature and biaxial unequal lateral pressure on the static mechanical properties of concrete. By analyzing the experimental data, we reached a series of conclusions and carried out theoretical research on this basis.