Publications by authors named "Tengis Tschaidse"
Background: Pancreatic ductal adenocarcinoma (PDAC) typically occurs in an older patient population. Yet, early-onset pancreatic cancer (EOPC) has one of the fastest growing incidence rates. This study investigated the influence of age and tumor location on postoperative morbidity and mortality in a large, real-world dataset.
View Article and Find Full Text PDFRationale: Colorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death worldwide. Distant metastases are still the main limit for patient survival. While liver metastases as well as peritoneal carcinomatosis can often either be resected or treated with systemic therapy, little options remain for brain metastases.
View Article and Find Full Text PDFMicrobiome Dysbiosis with Enterococcus Presence in the Upper Gastrointestinal Tract is A Risk Factor for Mortality in Patients Undergoing Surgery for Pancreatic Cancer.
Christoph K Stein-Thoeringer Bernhard W Renz Juliana De Castilhos Viktor von Ehrlich-Treuenstätt Ulrich Wirth Tengis Tschaidse
Ann Surg
January 2024
Article Synopsis
- Recent studies indicate that specific microbiota may influence complications and outcomes in patients undergoing pancreatic head resections.
- *A prospective study involving 101 patients utilized 16S rRNA sequencing to investigate the microbiome at surgical sites and found that variations in microbiome composition were linked to factors such as cancer type, age, and pre-surgical interventions.
- *In particular, higher levels of Enterococcus spp. in the bile were associated with increased risk of surgical site infections and higher mortality rates up to 24 months post-surgery.*
Article Synopsis
- Insulin-like growth factor 1 (IGF1) plays a crucial role in enhancing growth and metabolism in cells and demonstrates cardio-protective properties after acute myocardial infarction (AMI).
- A study showed that short-term IGF1 treatment improved heart function, reduced scar size, and increased capillary density in heart tissue over several weeks following AMI.
- The protective effects of IGF1 were linked to its impact on myeloid cells and the promotion of an anti-inflammatory response in macrophages, suggesting it helps modulate inflammation to preserve heart function after injury.