Development and validation of a nomogram to predict the survival and estimate surgical benefits for gastric cancer with liver metastasis receiving primary tumor resection.

Background: Surgical treatment has been widely controversial for gastric cancer accompanied by liver metastasis (GCLM). This paper aims to develop and validate a nomogram to predict the survival and estimate surgical benefits for GCLM patients.

Methods: A total of 616 GCLM patients from the Surveillance, Epidemiology, and End Results Program (SEER) database and 74 GCLM patients receiving primary tumor resection (PTR) from the Chinese center were included in this study.

Time-variant parity-time symmetry in frequency-scanning systems.

Parity-time (PT) symmetry is an active research area that provides a variety of new opportunities for different systems with novel functionalities. For instance, PT symmetry has been used in lasers and optoelectronic oscillators to achieve single-frequency lasing or oscillation. A single-frequency system is essentially a static PT-symmetric system, whose frequency is time-invariant.

MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway.

Background: Mex-3 RNA binding family members are well-established to be important in cancer development and progression. However, the functions of Mex-3 RNA binding family member A (MEX3A) in colorectal cancer (CRC) metastasis remain poorly understood. In this study, we aim to reveal the function and the mechanism of MEX3A in promoting CRC metastasis.

Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.

Abnormal regulation of RNA binding proteins (RBPs) plays an essential role in tumorigenesis and progression, but their functions and mechanisms remain largely elusive. Previously, we reported that Pumilio 1 (PUM1), a RBP, could regulate glycolysis metabolism and promote the progression of gastric cancer (GC). However, the role of PUM1 in tumor immune regulation remains largely elusive.

Phase-diagram investigation of frustrated 1D and 2D Ising models in OEO-based Ising machine.

Ising machines have emerged as promising solvers for combinatorial optimization problems in recent years. In practice, these problems are often mapped into a frustrated Ising model due to randomness or competing interactions, which reduces the success ratio for finding the optimal solution. In this study, we simulate one-dimensional and two-dimensional frustrated Ising models in an Ising machine based on the optoelectronic oscillator.

The predictive effect of immune therapy and chemotherapy under T cell-related gene prognostic index for Gastric cancer.

Gastric cancer (GC) is one of the most common malignancies in the human digestive tract. CD4+T cells can eliminate tumor cells directly through the mechanism of cytolysis, they can also indirectly attack tumor cells by regulating the tumor TME. A prognostic model of CD4+T cells is urgently needed to improve treatment strategies and explore the specifics of this interaction between CD4+T cells and gastric cancer cells.

Hybrid-integrated wideband tunable optoelectronic oscillator.

As a photonic-based microwave signal generation method, the optoelectronic oscillator (OEO) has the potential of meeting the increasing demand of practical applications for high frequency, broadband tunability and ultra-low phase noise. However, conventional OEO systems implemented with discrete optoelectronic devices have a bulky size and low reliability, which extremely limits their practical applications. In this paper, a hybrid-integrated wideband tunable OEO with low phase noise is proposed and experimentally demonstrated.

Directly modulated parity-time symmetric single-mode Fabry-Perot laser.

Effective manipulation of resonant mode, output power and modulation bandwidth of lasers are all of vital importance for practical application scenarios such as communication systems. We show that by breaking the parity-time (PT) symmetry, single mode operation lasing can be realized in an intrinsic multiple mode Fabry-Perot (FP) resonator. Two identical FP resonators are employed to establish a symmetric system and high output power can be achieved with lower fabrication difficulty and intracavity losses compared with ring resonators.

Single-photon microwave photonics.

With the rapid development of microwave photonics technology, high-speed processing and ultra-weak signal detection capability have become the main bottlenecks in many applications. Thanks to the ultra-weak signal detection capability and the extremely low timing jitter properties of single-photon detectors, the combination of single-photon detection and classical microwave photonics technology may provide a solution to break the above bottlenecks. In this paper, we first report a novel concept of single-photon microwave photonics (SP-MWP), a SP-MWP signal processing system with phase shifting and frequency filtering functionalities is demonstrated based on a superconducting nanowire single photon detector (SNSPD) and a successive time-correlated single photon counting (TCSPC) module.

Large-scale coherent Ising machine based on optoelectronic parametric oscillator.

Ising machines based on analog systems have the potential to accelerate the solution of ubiquitous combinatorial optimization problems. Although some artificial spins to support large-scale Ising machines have been reported, e.g.

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer.

As an RNA-binding protein, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is involved in enhancing the progression of a few malignant tumors by recognizing N6-methyladenosine on targeted RNA. However, the specific effects of IGF2BP2 on gastric cancer (GC) and the underlying mechanisms remain unclear. In this study, the expression level of IGF2BP2 was evaluated by analyzing data from a public database and performing immunohistochemical staining with GC specimens.

Simple method for microwave photonic temperature interrogation with high resolution and sensitivity.

We propose a microwave photonic temperature interrogation system with high resolution and sensitivity based on temperature-to-time mapping with a simple structure. In this work, a bidirectional chirped optical signal is constructed, and the temperature information is mapped to the time interval change of the output pulses by filtering the bidirectional chirped optical signal using the transmission spectrum of a Fabry-Perot filter. Only a low-speed oscilloscope is required to extract the time interval of the output pulses in the proposed scheme, and complex data processing as well as synchronizing processes are avoided.

Schlafen family is a prognostic biomarker and corresponds with immune infiltration in gastric cancer.

The Schlafen (SLFN) gene family plays an important role in immune cell differentiation and immune regulation. Previous studies have found that the increased SLFN5 expression in patients with intestinal metaplasia correlates with gastric cancer (GC) progression. However, no investigation has been conducted on the SLFN family in GC.

Photonic-assisted radio frequency self-interference cancellation and frequency down-conversion based on polarization multiplexing modulation.

We report a photonic-assisted radio frequency self-interference cancellation (RF-SIC) and frequency down-conversion scheme based on a dual-polarization Mach-Zehnder modulator (DP-MZM) by using a polarization manipulation method. In the proposed scheme, the self-interference signal is directly canceled in the optical domain by simply controlling the polarization states between the output of the DP-MZM and the polarizer. Frequency down-conversion is achieved by optoelectronic frequency mixing.

Ultra-fast full-field optical characterization of CW lasers based on optical frequency comb, wavelength-to-time mapping and phase-diversity.

Optical frequency comb (OFC), a periodic optical pulse train in time domain, has been widely employed to measure optical frequency due to its equidistant modes in the frequency domain. Here, we propose and demonstrate a novel optical spectrum analyzer for CW lasers based on stretching the OFC in a dispersive element and mapping the frequency comb into the time domain. The optical spectrum analyzer also provides instantaneous full-field (wavelength, amplitude and phase) optical characterization capability by combining with optical phase-diversity technology.

Bandwidth superposition of linearly chirped microwave waveforms based on a Fourier domain mode-locked optoelectronic oscillator.

Optoelectronic oscillators (OEOs) are promising for radar, communication and electronic countermeasure systems. Among them, frequency-scanning OEOs with wide instantaneous bandwidth are needed for many advanced applications. In this work, we demonstrate a novel system to generate bandwidth-doubled linearly chirped microwave waveforms (LCMWs) based on bandwidth superposition using a Fourier domain mode-locked OEO (FDML OEO).

Combination of the ratio between metastatic and harvested lymph nodes and negative lymph node count as a prognostic indicator in advanced gastric cancer: a retrospective cohort study.

Background: The aim of our study was to examine the impact of the combination of the ratio between metastatic and harvested lymph nodes (RML) and negative lymph node (NLN) count on overall survival (OS) in patients with advanced gastric cancer (GC).

Methods: The clinicopathological data of 2,952 advanced GC patients who received curative resection between 1994 and 2015 were collected. They were divided into four groups according to the RML: 0, 0-0.

Poor Prognosis and Therapeutic Responses in LILRB1-Expressing M2 Macrophages-Enriched Gastric Cancer Patients.

Immunosuppressive molecules are valuable prognostic biomarkers across different cancer types. Leukocyte immunoglobulin like receptor subfamily B1 (LILRB1) is considered to be an immunosuppressive molecule, which is an important receptor of human leukocyte antigen G. However, the clinical significance of LILRB1 expression in gastric cancer remains unexplored.

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

Chemotherapy plays an irreplaceable role in the treatment of GC, but currently available chemotherapeutic drugs are not ideal. The application of medicinal plants is an important direction for new drug discovery. Through drug screening of GC organoids, we determined that ailanthone has an anticancer effect on GC cells and .

Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer.

Zinc finger proteins (ZNFs) are a class of protein containing zinc finger domains, and they play an important role in tumor progression. However, as a member of the ZNFs family, the effect of ZNF460 in colon cancer remains unclear. In this study, we found that the expression of ZNF460 protein were markedly increased in clinical colon cancer tissues compared with para-cancer non-cancerous tissues by tissue immunohistochemistry (IHC) and western blot (WB).

Microwave photonic injection locking frequency divider based on a tunable optoelectronic oscillator.

We present a novel broadband divide-by-2 microwave photonic injection locking frequency divider (ILFD) based on a dual-loop optoelectronic oscillator (OEO). In the proposed scheme, a tunable microwave photonic filter is used to replace the traditional electrical filter, which makes sure a large tuning range of the ILFD. The microwave photonic ILFD whose center frequency tracks the tunable frequency of the free-running OEO, links up with every single locking range together.

Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p/MSI1 Axis.

Background: Exosomal circular RNAs (circRNAs) can act as biomarkers and play crucial roles in colorectal cancer (CRC) and radiosensitivity. The aim of this study was to explore the functions and regulatory mechanism of exosomal circRNA intraflagellar transport 80 (circ_IFT80) in tumorigenesis and radiosensitivity of CRC.

Methods: Exosomes were detected using transmission electron microscopy (TEM).

Prognostic Significance of ACP5 in Human Gastric Cancer.

Introduction: Tartrate-resistant acid phosphatase (ACP5) plays crucial roles in multiple pathological processes, including the genesis and progression of malignant tumors. We performed this study with the purpose of determining whether ACP5 is a crucial biomarker significantly related to prognoses of gastric cancer (GC) patients.

Methods: The expression level of ACP5 level was assessed among 170 GC specimens using immunohistochemistry.

Photonic generation of multiband and multi-format microwave signals based on a single modulator.

We report a photonic scheme to generate multiband and multi-format microwave signals based on a commercial dual-polarization Mach-Zehnder modulator (DP-MZM). The key novelty of this work is the compact signal generator benefitting from the single modulator and the flexible multi-format signals at the multiband. The upper Mach-Zehnder modulator (MZM) of the DP-MZM is used to generate an optical frequency comb, while the lower MZM is driven by baseband electrical coding or single-chirp signal to obtain the multi-format modulated optical signal.

Broadband random optoelectronic oscillator.

Random scattering of light in transmission media has attracted a great deal of attention in the field of photonics over the past few decades. An optoelectronic oscillator (OEO) is a microwave photonic system offering unbeatable features for the generation of microwave oscillations with ultra-low phase noise. Here, we combine the unique features of random scattering and OEO technologies by proposing an OEO structure based on random distributed feedback.