The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network.

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is an orphan nuclear receptor that is over-expressed in cancer and promotes cell proliferation, migration, transformation, and chemoresistance. Increased expression and function of NR4A2 have been attributed to various signaling pathways, but little is known about microRNA (miRNA) regulation of NR4A2 in cancer. To investigate the posttranscriptional regulation of NR4A2, we used a 3' untranslated region (UTR) reporter screen and identified miR-34 as a putative regulator of NR4A2.

Regulation of Nuclear Receptor Nur77 by miR-124.

The nuclear receptor Nur77 is commonly upregulated in adult cancers and has oncogenic functions. Nur77 is an immediate-early response gene that acts as a transcription factor to promote proliferation and protect cells from apoptosis. Conversely, Nur77 can translocate to the mitochondria and induce apoptosis upon treatment with various cytotoxic agents.

The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer.

Nuclear receptor (NR) subfamily 4 group A (NR4A) is a family of three highly homologous orphan nuclear receptors that have multiple physiological and pathological roles, including some in cancer. These NRs are reportedly dysregulated in multiple cancer types, with many studies demonstrating pro-oncogenic roles for NR4A1 (Nur77) and NR4A2 (Nurr1). Additionally, NR4A1 and NR4A3 (Nor-1) are described as tumor suppressors in leukemia.

Target of rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death.

Background: The target of rapamycin complex 1 (TORC1) is an evolutionarily conserved signal transduction pathway activated by environmental nutrients that regulates gene transcription to control cell growth and proliferation. How TORC1 modulates chromatin structure to control gene expression, however, is largely unknown. Because TORC1 is a major transducer of environmental information, defining this process has critical implications for both understanding environmental effects on epigenetic processes and the role of aberrant TORC1 signaling in many diseases, including cancer, diabetes, and cardiovascular disease.

Designing small-sided games for training tactical aspects in soccer: extrapolating pitch sizes from full-size professional matches.

The aims of this study were to examine the (1) individual playing area, (2) length and width of the rectangle encompassing the individual playing area and (3) distance between the goalkeepers and their nearest team-mates during professional soccer matches and compare these to previously reported pitch sizes for small-sided games (SSGs). Data were collected from four Spanish La Liga matches of the 2002-03 season, and notated post-event using the Amisco system. The pitch sizes obtained from real matches were smaller and different from those used previously for SSGs.

Effect of playing tactics on achieving score-box possessions in a random series of team possessions from Norwegian professional soccer matches.

Methods of analysis that include an assessment of opponent interactions are thought to provide a more valid means of team match performance. The purpose of this study was to examine the effect of playing tactics on achieving score-box possession by assessing opponent interactions in Norwegian elite soccer matches. We analysed a random series of 1703 team possessions from 163 of 182 (90%) matches played in the professional men's league during the 2004 season.

Effect of playing tactics on goal scoring in Norwegian professional soccer.

Methods that include an assessment of opponent interactions are thought to provide a more valid analysis of team match performance. The purpose of this study was to examine the effect of playing tactics on goal scoring by assessing opponent interactions in Norwegian elite soccer. The sample included 203 team possessions leading to goals (cases) and 1688 random team possessions (control group) from 163 of 182 (90%) matches played in the men's professional league during the 2004 season.

Cd(13-x)In(y)Sb10 (x approximately 2.7, y approximately 1.5): an interstitial-free variant of thermoelectric beta-Zn4Sb3.

Cd(13-x)In(y)Sb10 (x approximately 2.7, y approximately 1.5) was synthesized in the form of mm-sized crystals from reaction mixtures containing excess cadmium.

Metastable Cd4Sb3: a complex structured intermetallic compound with semiconductor properties.

The metastable binary intermetallic compound Cd4Sb3 was obtained as polycrystalline ingot by quenching stoichiometric Cd-Sb melts and as mm-sized crystals by employing Bi or Sn fluxes. The compound crystallizes in the monoclinic space group Pn with a = 11.4975(5) A, b = 26.

Video analysis of injuries and incidents in Norwegian professional football.

Objectives: This study describes the characteristics of injuries and high risk situations in the Norwegian professional football league during one competitive season using Football Incident Analysis (FIA), a video based method.

Methods: Videotapes and injury information were collected prospectively for 174 of 182 (96%) regular league matches during the 2000 season. Incidents where the match was interrupted due to an assumed injury were analysed using FIA to examine the characteristics of the playing situation causing the incident.

A prospective video-based analysis of injury situations in elite male football: football incident analysis.

Background: The mechanisms for football injuries are largely unknown.

Aim: To describe the characteristics of injury situations in elite male football using a video-based method called football incident analysis.

Study Design: Prospective cohort study.

Football incident analysis: a new video based method to describe injury mechanisms in professional football.

Objectives: To develop and test a new video based method for match analysis that combines football specific and medical information to achieve a better understanding of the injury mechanisms and events leading up to high risk situations.

Methods: Football incident analysis (FIA) is a video based method describing incidents that may result in an injury using 19 variables and categories modified from match analysis. Videos from 35 of 76 (46%) official Norwegian under 21 matches played from 1994 to 1998 were analysed.

Diminished greenness of tomato leaves exposed to ozone and post-exposure recovery of greenness.

The response to ozone (O(3)) of greenness, in terms of estimated total chlorophyll concentration (Chl), of leaves at three plant canopy levels was studied in tomato (Lycopersicon esculentum Mill.) over a 10-day period following O(3) exposure. Plants of the cultivars 'New Yorker' and 'Tiny Tim' were grown at 25/15 degrees or 30/15 degrees day/night temperatures in growth chambers and exposed to 0.