CORM-2 Pretreatment Attenuates Inflammation-mediated Islet Dysfunction.

During the process of human islet isolation a cascade of stressful events are triggered and negatively influence islet yield, viability, and function, including the production of proinflammatory cytokines and activation of apoptosis. Carbon monoxide-releasing molecule 2 (CORM-2) is a donor of carbon monoxide (CO) and can release CO spontaneously. Accumulating studies suggest that CORM-2 exerts cytoprotective and anti-inflammatory properties.

V4+ T Cells: A Novel IL-17-Producing T Subsets during the Early Phase of Chlamydial Airway Infection in Mice.

Our previous studies showed that T cells provided immune protection against Chlamydial (Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung T cell subsets, specifically the IL-17 and IFN production by them following Cm lung infection. Our results found that five T cell subsets, V1+ T, V2+ T, V4+ T, V5+ T, and V6+ T, expressed in lungs of naïve mice, while Cm lung infection mainly induced the proliferation and activation of V4+ T cells at day 3 p.