Publications by authors named "Teng-Da Wang"
Article Synopsis
- Renal cell carcinoma (RCC), particularly clear cell RCC (ccRCC), was the focus of a study analyzing single-cell RNA sequencing (scRNA-seq) data to understand how the tumor microenvironment (TME) connects with clinical outcomes and immunotherapy responses.
- Researchers identified three distinct differentiation subsets of ccRCC cells and categorized ccRCC samples into four molecular subtypes based on differentiation-related genes (DRGs), which correlated with patient prognosis and immune checkpoint gene expression.
- The study developed a prognostic risk signature (PRS) and an easy-to-use nomogram based on the PRS, enabling more accurate predictions of ccRCC patient outcomes and emphasizing the importance of TME evolution in treatment responses.
Objective: To investigate the molecular mechanisms underlying the effects of arsenic trioxide (AsO) in combination with leflunomide on the hamster-to-rat heart xenotransplant.
Methods: Transplantation of LVG hamster hearts to Lewis rats was performed by anastomosis of vessels in the neck using end-to-end anastomosis with a non-suture cuff technique. Four groups of recipient rats (n=6 in each) were treated with normal saline (control), AsO [5 mg/(kg·day) intraperitoneally], leflunomide [5 mg/(kg·d) orally], or leflunomide [5 mg/(kg·d)+AsO [5 mg/(kg·d)] in combination.
There is increasing evidence that bone morphogenetic proteins (BMP) are involved in the proliferation and drug tolerance of kidney cancer. However, the molecular mechanism of BMP8A in renal cell proliferation and drug tolerance is not clear. Here we showed that BMP8A was highly expressed in renal cell carcinoma, which suggests a poor prognosis of ccRCC.
View Article and Find Full Text PDFBackground: The long noncoding RNA (lncRNA) OTUD6B antisense RNA 1 (OTUD6B-AS1) is oriented in an antisense direction to the protein-coding gene OTUD6B on the opposite DNA strand. TCGA database data show that the expression of the lncRNA OTUD6B-AS1 is downregulated and that OTUD6B-AS1 acts as an antioncogene in a variety of tumors. However, the expression and biological functions of the lncRNA OTUD6B-AS1 are still unknown in tumors, including clear cell renal cell carcinoma (ccRCC).
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