Fatigue, sleep quality, depression symptoms, and antiseizure medication resistance in patients with newly diagnosed epilepsy.

Background: Complaints of fatigue and poor sleep quality are common in patients with epilepsy. Fatigue may precipitate seizures, and patients with poor sleep quality have higher frequency of seizures and are more likely to have symptoms of depression.

Objectives: This study aims to determine the association of baseline fatigue and sleep quality with antiseizure medication (ASM) resistance in patients with newly diagnosed epilepsy (PWNDE).

Functional Verification of Differentially Expressed Genes Following DENV2 Infection in .

The dengue virus (DENV) is primarily transmitted by . Investigating genes associated with mosquito susceptibility to DENV2 offers a theoretical foundation for targeted interventions to regulate or block viral replication and transmission within mosquitoes. Based on the transcriptomic analyses of the midgut and salivary glands from infected with DENV2, alongside analyses of Aag2 cell infections, 24 genes potentially related to the regulation of infection with DENV2 were selected.

Amino-Acid-Induced Circularly Polarized Luminescence of Octahedral Lanthanide Cage.

Chiral metal organic cage compounds with excellent circularly polarized luminescent performance have broad application prospects in many fields. Herein, two lanthanide complexes with luminescent properties in the form of racemic hexagonal octahedral cages were synthesized using a tri (β-diketone) ligand. Eu(CHFO)(HO) exhibited red light emission with high quantum yields of 61 %.

Dual-mode colorimetric and chemiluminescence aptasensor for organophosphorus pesticides detection using aptamer-regulated peroxidase-like activity of TA-Cu.

The residues of organophosphorus pesticides (OPs) in food pose a huge threat to human health. Therefore, the development of detection methods with simple design and high sensitivity is urgently needed. Here, a colorimetric/chemiluminescence (CL) dual-mode aptasensor strategy with high selectivity and sensitivity for detecting Parathion-methyl (PM) was designed based on aptamer-regulated nanozyme activity.

Phase estimation via coherent and photon-catalyzed squeezed vacuum states.

The research focused on enhancing the measurement accuracy through the use of non-Gaussian states has garnered increasing attention. In this study, we propose a scheme to input the coherent state mixed with a photon-catalyzed squeezed vacuum state into the Mach-Zender interferometer to enhance phase measurement accuracy. The findings demonstrate that photon catalysis, particularly multi-photon catalysis, can effectively improve the phase sensitivity of parity detection and the quantum Fisher information.

Optimal preservation condition for the extraction of cell-free DNA from bile of patients with biliary tract cancer.

Background: Patients with biliary tract cancer (BTC) often have dismal outcomes due to the poor performance of traditional methods for early diagnosis. Recently, bile cell-free DNA (cfDNA) has been reported as a potential liquid biopsy material for BTC diagnosis. However, bile is a complex alkaline aqueous medium, and the proper storage conditions for bile remain to be explored.

The shifts in microbial interactions and gene expression caused by temperature and nutrient loading influence Raphidiopsis raciborskii blooms.

Climate change and the trophic status of water bodies are important factors in global occurrence of cyanobacterial blooms. The aim of this study was to explore the cyanobacteria‒bacterial interactions that occur during Raphidiopsis raciborskii (R. raciborskii) blooms by conducting microcosm simulation experiments at different temperatures (20 °C and 30 °C) and with different phosphorus concentrations (0.

[Characteristics of Phytoplankton Community Structure in Lakes of Wetlands Dominated by Different Aquatic Plants and Its Driving Factors].

In wetland ecosystems, small shallow lakes are critical transition zones of land and water, which are usually dominated by aquatic plants with different growth forms. However, the differences and key influencing factors of phytoplankton communities in shallow lakes dominated by different aquatic plants are unclear. On this basis, nine surveys were conducted at five sampling sites of three lakes in Zhangye National Wetland Park from June to November in 2022, which were respectively dominated by the emergent （LL）, the submerged （CL）, and the floating-leaved （SL）.

Evaluation of Double Self-Immolative Linker-Based Antibody-Drug Conjugate FDA022-BB05 with Enhanced Therapeutic Potential.

Typical antibody-drug conjugates (ADCs) with valine-alanine linkage, often conjugated with the amino group in payloads, face challenges when interacting with hydroxyl group-containing payloads. Herein, we introduced a transformative Val-Ala-based double self-immolative linker-payload platform, reshaping ADCs by optimizing hydroxyl group-containing payload integration. Utilizing this platform, was successfully conjugated with the hydroxyl group-containing payload DXd using trastuzumab (FDA022) as the monoclonal antibody (mAb).

Dendrite-Free Lithium Batteries Enabled by an Artificial High-Dielectric Biopolymer Interface Layer.

Lithium (Li) metal batteries face challenges, such as dendrite growth and electrolyte interface instability. Artificial interface layers alleviate these issues. Here, cellulose nanocrystal (CNC) nanomembranes, with excellent mechanical properties and high specific surface areas, combine with polyvinylidene-hexafluoropropylene (PVDF-HFP) porous membranes to form an artificial solid electrolyte interphase (SEI) layer.

Effects of Multi-Sensory Stimulation on Apathy Symptoms in Elderly Patients with Alzheimer's Disease.

Background: We aimed to explore the effect of multi-sensory stimulation on apathy symptoms in elderly patients with Alzheimer's disease (AD).

Methods: Eighty elderly patients with AD admitted to the Third Affiliated Hospital of Qiqihar Medical University, China from January 2022 to February 2023 were selected as the research objects by convenient sampling method. According to the random number table, they were divided into intervention group and control group, with 40 cases in each group.

Animal Experimental Study of Bioabsorbable Left Atrial Appendage Occluder.

Left atrial appendage (LAA) closure can prevent stroke in high-risk patients with atrial fibrillation.A bioabsorbable LAA occluder made of degradable polymer materials, such as polydioxanone (PDO) and poly-L-lactic acid (PLA), and nitinol wire was used. Occluders were successfully implanted in 18 Chinese rural dogs, 2 of which died within 48 hours after operation due to pericardial tamponade and hemorrhage, respectively.

Identification of whole-genome mutations and structural variations of bile cell-free DNA in cholangiocarcinoma.

Bile cell-free DNA (cfDNA) has been reported as a promising liquid biopsy tool for cholangiocarcinoma (CCA), however, the whole-genome mutation landscape and structural variants (SVs) of bile cfDNA remains unknown. Here we performed whole-genome sequencing on bile cfDNA and analyzed the correlation between mutation characteristics of bile cfDNA and clinical prognosis. TP53 and KRAS were the most frequently mutated genes, and the RTK/RAS, homologous recombination (HR), and HIPPO were top three pathways containing most gene mutations.

Effectiveness of surgery combined with photodynamic therapy for recurrent respiratory papillomatosis.

Objective: This study aims to analyze the safety and effectiveness of a new model of surgery combined with Photodynamic therapy for treating Recurrent Respiratory Papillomatosis (RRP).

Methods: Review the case data of patients with RRP who opted for comprehensive surgery combined with Photodynamic therapy at the Nanjing BenQ Medical Center, from January 2021 to May 2023. The efficacy of this program was evaluated by comparing the annual number of surgeries and Derkay scores before and after the surgery.

Clinicopathological spectrum, management, and outcome of ectopic parathyroid carcinoma: Experience with 24 cases.

Purpose: Ectopic parathyroid carcinoma (EPC) is a rare clinical entity with multiple diagnostic pitfalls, making surgical cures challenging. We assessed the clinicopathological spectrum and outcome of EPCs.

Methods: In this retrospective cohort study, 24 EPCs were identified from 133 PC patients treated at a tertiary referral center.

FZ-AD005, a Novel DLL3-Targeted Antibody-Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models.

Delta-like ligand 3 (DLL3) is overexpressed in small cell lung cancer (SCLC) and has been considered an attractive target for SCLC therapy. Rovalpituzumab tesirine was the first DLL3-targeted antibody-drug conjugate (ADC) to enter clinical studies. However, serious adverse events limited progress in the treatment of SCLC with rovalpituzumab tesirine.

Risk Factors of Distant Metastatic Parathyroid Carcinoma and Insights into Therapeutic Perspectives.

Background: Distant metastatic parathyroid carcinoma (DM-PC) is a rare but often lethal entity with limited data about prognostic indicators. We sought to investigate the risk factors, patterns, and outcomes of DM-PC.

Methods: In this observational cohort study, 126 patients who underwent surgery for PC at a tertiary referral center from 2010 to 2023 were enrolled, among whom 38 had DMs.

Detection and identification of circulating tumor cells in parathyroid tumors and correlation analysis with clinicopathological features.

Introduction: The differential diagnosis of parathyroid carcinoma (PC)/parathyroid adenoma (PA) in parathyroid tumors is critical for their management and prognosis. Circulating tumor cells (CTCs) identification in the peripheral blood of parathyroid tumors remains unknown. In this study, we proposed to investigate the differences of CTCs in PC/PA and the relationship with clinicopathologic features to assess its relevance to PC and value in identifying PC/PA.