SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC), a predominant subtype of renal cell carcinoma, significantly contributes to the heightened morbidity and mortality in individuals diagnosed with urologic tumors. The challenges posed by high malignancy at the initial diagnosis of ccRCC, therapeutic resistance, and unfavorable patient prognosis remain largely unresolved. Our findings indicate that SEPT5 is upregulated in ccRCC and this upregulation is associated with an adverse prognosis for ccRCC patients.

Linoleic acid alleviates aluminum toxicity by modulating fatty acid composition and redox homeostasis in wheat (Triticum aestivum) seedlings.

Lipids, as key components of biological membranes, play vital roles in sensing and initiating plant responses to various abiotic stresses. Here, the alteration of membrane fatty acids in wheat roots under Al stress was investigated using two genotypes differing in Al tolerance, and the role of linoleic acid in Al tolerance was comprehensively explored. Significant differences in the fatty acid profiles were observed, with increased linoleic acid accumulation in the Al-tolerant genotype.

Advances in the impact of ASS1 dysregulation on metabolic reprogramming of tumor cells.

ASS1(argininosuccinate synthase 1) is a rate-limiting enzyme in the urea cycle, catalyzing the synthesis of argininosuccinate from citrulline and aspartate to ultimately produce arginine and support cellular metabolism. Increasing evidence suggests that ASS1 is commonly dysregulated in the tumor microenvironment, promoting tumor cell metastasis and infiltration. With a deeper understanding of tumor metabolic reprogramming in recent years, the impact of ASS1 dysregulation on abnormal tumor metabolism has attracted growing interest among researchers.

AL16431.1 is identified as a biomarker for bladder cancer progression and immunotherapy response.

LncRNA AL161431.1 is currently known as a factor that can promote epithelial-mesenchymal transition. However, its role in the prognosis, immune infiltration and progression of bladder cancer (BLCA)patients is still unclear.

Single-Cell RNA Sequencing Uncovers Molecular Features Underlying the Disrupted Neurogenesis Following Traumatic Brain Injury.

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with limited effective treatment strategies. Endogenous neural stem cells (NSCs) give rise to neurons and glial cells throughout life. However, NSCs are more likely to differentiate into glial cells rather than neurons at the lesion site after TBI and the underlying molecular mechanism remains largely unknown.

Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.

Genome-wide association studies (GWASs) have reported multiple risk loci for schizophrenia (SCZ). However, the majority of the associations were from populations of European ancestry. Here we conducted a large-scale GWAS in Eastern Asian populations (29,519 cases and 44,392 controls) and identified ten Eastern Asian-specific risk loci, two of which have not been previously reported.

Dual-frequency ultrasonic-assisted enzymolysis for synthesis of microstructure regulated biomass-derived porous carbon for high-performance supercapacitors.

Biomass-derived porous carbon (PC) has emerged as a promising candidate for electrode materials in energy storage applications, effective pretreatment of the precursor is a key strategy for enhancing the electrochemical performance of PC. However, challenges remain in achieving this goal through environmentally friendly, simple, and efficient methods. In this paper, a dual-frequency ultrasonic-assisted enzymolysis strategy combined with carbonization-activation method was proposed to prepare high-performance garlic peel-derived PC (DUGPC) for supercapacitors.

Novel methyldithiocarbazate derivatives as NDM-1 inhibitors to combat multidrug-resistant bacterial infection with β-lactams.

Given the ever-evolving landscape of antimicrobial resistance, the emergence of New Delhi metallo-β-lactamase-1 (NDM-1) has introduced a formidable challenge to global public health. In previous research, we identified the Compound Zndm19 as an NDM-1 inhibitor and reported Zndm19 derivatives, which exhibited moderate antibacterial activity when combined with meropenem (MEM). This moderate activity may have been due to the inability of Zndm19 to efficiently penetrate the bacterial outer membrane or its susceptibility to hydrolysis, which prevented it from exerting strong enzyme inhibition in synergy with bacterial cells.

Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.

Aims/introduction: Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound-healing processes. Interleukin-37 (IL-37) is a natural suppressor of innate inflammation. Here, we aim to investigate the potential of IL-37 in enhancing the healing process of diabetic wounds.

Engineered microalgae for photo-sonodynamic synergistic therapy in breast cancer treatment.

Dynamic therapies such as photodynamic therapy (PDT) and sonodynamic therapy (SDT) have potential in cancer treatment. Microalgae have attracted increasing attention because of their high active mobility, flexibility in terms of functionality, and good biocompatibility. In this study, surface-engineered microalgae Chlorella vulgaris (Chl) modified with metal‒organic framework (MOF) nanoparticles (denoted Chl-MOF) are successfully developed for synergistic photo-sonodynamic therapy and immunotherapy.

Atherosclerotic plaque evolution predicts cerebral ischemic events in patients with intracranial atherosclerosis: a multicentre longitudinal study using high-resolution MRI.

Background: Intracranial atherosclerosis (ICAS) is the leading cause of ischemic stroke in Asians and the recurrent rate remains high despite the optimal medical treatment. This study aimed to confirm that follow-up high-resolution magnetic resonance imaging (hrMRI) provided essential values in predicting subsequent cerebral ischemic events in patients with ICAS.

Methods: Patients with moderate to severe stenosis in the middle cerebral artery (MCA) defined by magnetic resonance (MRA) or computed tomography angiography (CTA) were recruited from three centers retrospectively.

A literature review of artificial intelligence (AI) for medical image segmentation: from AI and explainable AI to trustworthy AI.

Background And Objective: Medical image segmentation is a vital aspect of medical image processing, allowing healthcare professionals to conduct precise and comprehensive lesion analyses. Traditional segmentation methods are often labor intensive and influenced by the subjectivity of individual physicians. The advent of artificial intelligence (AI) has transformed this field by reducing the workload of physicians, and improving the accuracy and efficiency of disease diagnosis.

Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration.

Regeneration of injured central nervous system (CNS) axons is highly restricted, leading to permanent neurological deficits. The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously expressed in eukaryotic cells, plays critical roles in development, brain plasticity, and tissues regeneration. However, little is known about the role of Marcks in CNS axon regeneration.

N-doped porous carbon derived from different lignocellulosic biomass models for high-performance supercapacitors: the role of lignin, cellulose and hemicellulose.

Biomass-derived porous carbon (PC) has been widely studied in the field of supercapacitors due to its low cost, sustainability and developed pore structure, but how to screen the precursors of high-performance PC is still a major difficulty. Herein, six lignocellulosic biomass models based on different compositions were innovatively constructed and prepared into high-performance PC by a synergistic activation-doping strategy. The results show that the synergistic activation-doping strategy has a certain universality for biomass models.

Thiamethoxam-Loaded Ethyl Cellulose Microspheres for Extending the Efficacy Duration and Reducing the Toxicity on the Growth of Maize ( L.).

Thiamethoxam has been widely used in agriculture due to its excellent insecticidal activity. However, thiamethoxam is prone to loss during practical applications, especially in soil application, which seriously reduces its performance. In this work, thiamethoxam is loaded in ethyl cellulose microspheres to solve this issue, and the thiamethoxam-loaded ethyl cellulose microspheres (thiamethoxam/EC) are facilely and effectively fabricated by emulsified solvent volatilization.

A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive heavily pretreated solid tumors: results from a phase Ia/Ib first-in-human, open-label, single center study.

Background: IAH0968 is an afucosylated anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody which improved the activity of antibody-dependent cellular cytotoxicity (ADCC) and superior anti-tumor efficacy.

Methods: To determine the maximum tolerated dose (MTD) with dose-limiting toxicity (DLT), a single institution, phase Ia/Ib study was undertaken, using 3 + 3 design. The primary endpoints were safety, tolerability and preliminary clinical activity.

Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer.

Background: Several observational studies have suggested that type 2 diabetes (T2D) is a risk factor for skin cancer, and antidiabetic drugs may reduce skin cancer risk. Nevertheless, the findings remain ambiguous. This Mendelian randomization (MR) study aimed to investigate the causal association of T2D with skin cancer and evaluate the potential impact of antidiabetic drug targets on skin cancer.

Milk metabolite profiling of dairy cows as influenced by mastitis.

Mastitis is a disease with frequent incidence in dairy cows, causing huge financial losses to the dairy industry globally. The identification of certain biomarkers is crucial for the early diagnosis and management of mastitis. Metabolomics technology is a useful tool to accurately and efficiently analyze the changes of metabolites in biofluids in response to internal and external stimulations.

[The characteristics of pharyngea microbiological in children with obstructive sleep apnea].

This study aimed to explore the possible pathogenesis of OSA from the perspective of microbiology by evaluate the change in pharyngeal microbiome of OSA children, and provide new ideas for clinical prevention, diagnosis and treatment. Randomly enrolled 20 children with OSA as OSA group and 20 children without OSA as control group. The swallow swab of each children been collected.

When Push Comes to Shove: Unravelling the Developmental and Longitudinal Dynamic Relationship between Bullying and Empathy in Chinese School Children.

While bullying has significant long-term impacts on mental health, the developmental relationship between empathy and bullying behaviors remains unclear. Specifically, it is uncertain whether bullying perpetration and victimization predict changes in empathy over time or if empathy influences these behaviors. This study addresses this gap by examining the longitudinal dynamic relationship between empathy, bullying perpetration, and victimization.