Elevated bile acids induce circadian rhythm sleep disorders in chronic liver diseases.

Background & Aims: Sleep disorders (SDs) are common in chronic liver diseases (CLDs). Some SDs arise from impaired internal clock and are hence circadian rhythm SDs (CRSDs). Bile acids (BAs), whose levels are increased in many CLDs, reciprocally interact with circadian rhythm.

Incidence and risk factor analysis of moderate-to-severe pain after preoperative CT-guided hook-wire puncture localization of pulmonary nodules.

Background: Pain is a relatively common complication after hook-wire puncture localization. However, the problem of pain occurrence following this localization procedure has not been sufficiently examined. In this prospective study, we aimed to investigate the incidence and risk factors associated with acute pain after preoperative CT-guided hook-wire puncture localization of pulmonary nodules.

Artificial river flow regulation triggered spatio-temporal changes in marine macrobenthos of the Yellow River Estuary.

The Water Sediment Discharge Regulation (WSR) in the Yellow River transports a vast quantity of freshwater and materials to the Bohai Sea within 20 days, significantly altering the ambient environment of the estuary. To elucidate the ecological impacts of this typically artificial flood event, we investigated the benthic habitats and macrobenthic biodiversity within the Affected Core Area (ACA) influenced by this discharge. Our results show that: (1) The discharge created an area with extreme environmental conditions, extending from the southern estuary to Laizhou Bay.

The Overload Effect on the Crack Tip Damage Mechanism in a 7075 Aluminum Alloy.

In the serviced components of a 7075 aluminum alloy, the propagation of fatigue crack can be retarded because of the overload effect; however, the corresponding retardation mechanisms are complex. To provide further insights into the retardation mechanisms of 7075 aluminum alloys, this study addresses the crack tip damage response of a cracked 7075 aluminum alloy under an overload effect. Based on the dual-scale modeling approach and the damage-coupled crystal plasticity model, the effect of the microstructure of a 7075 aluminum alloy on the damage behavior ahead of the crack tip under an overload was studied.

Outcome of treatment modalities for spontaneous esophageal rupture: a meta-analysis and case series.

Background: Current treatment modalities for spontaneous esophageal perforation remain controversial because of their rarity.

Objective: To describe our institution's experience in managing patients with spontaneous esophageal rupture and conduct a meta-analysis of existing studies to determine the best evidence-based treatment options.

Methods: We enrolled patients with spontaneous esophageal rupture who underwent their first treatment at our institution.

Release and Degradation Mechanism of Modified Polyvinyl Alcohol-Based Double-Layer Coated Controlled-Release Phosphate Fertilizer.

This study aims to improve the slow-release performance of a film material for a controlled-release fertilizer (CRF) while enhancing its biodegradability. A water-based biodegradable polymer material doped with biochar (BC) was prepared from modified polyvinyl alcohol (PVA) with polyvinylpyrrolidone (PVP) and chitosan (CTS), hereinafter referred to as PVA/PVP-CTSBC. An environmentally friendly novel controlled-release phosphate fertilizer (CRPF) was developed using PVA/PVP-CTSBC as the film.

Monitoring of Sweat Ions and Physiological Parameters via a Reconfigurable Modular System.

In recent years, wearable sensors have revolutionized health monitoring by enabling continuous, real-time tracking of human health and performance. These noninvasive devices are usually designed to monitor human physical state and biochemical markers. However, enhancing their functionalities often demands intricate customization by designers and additional expenses for users.

Query-Oriented Micro-Video Summarization.

Query-oriented micro-video summarization task aims to generate a concise sentence with two properties: (a) summarizing the main semantic of the micro-video and (b) being expressed in the form of search queries to facilitate retrieval. Despite its enormous application value in the retrieval area, this direction has barely been explored. Previous studies of summarization mostly focus on the content summarization for traditional long videos.

Pulmonary vagus nerve transection for chronic cough after video-assisted lobectomy: a randomized controlled trial.

Background: Chronic cough is common after lobectomy. Vagus nerves are part of the cough reflex. Accordingly, transection of the pulmonary branches of vagus nerve may prevent chronic cough.

HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism.

Cancer metabolism has emerged as a major target for cancer therapy, while the state of mitochondrial drugs has remained largely unexplored, partly due to an inadequate understanding of various mitochondrial functions in tumor contexts. Here, we report that HOMER3 is highly expressed in non-small cell lung cancer (NSCLC) and is closely correlated with poor prognosis. Lung cancer cells with low levels of HOMER3 are found to show significant mitochondrial dysfunction, thereby suppressing their proliferation and metastasis in vivo and in vitro.

A Transformer-Based Channel Estimation Method for OTFS Systems.

Orthogonal time frequency space (OTFS) is a novel modulation scheme that enables reliable communication in high-mobility environments. In this paper, we propose a Transformer-based channel estimation method for OTFS systems. Initially, the threshold method is utilized to obtain preliminary channel estimation results.

Evaluation of pain levels treated by the distal end of the hook-wire positioning needle: A randomized controlled study.

Background: Severe pain can be expected among adult patients undergoing hook-wire CT-guided localization of pulmonary nodules. We compared varying pain degrees between two different treatment techniques.

Methods: Data from 100 patients who underwent hook-wire puncture localization under preoperative CT between May 2022 and October 2022 were prospectively reviewed.

VIDAR-Based Road-Surface-Pothole-Detection Method.

This paper presents a VIDAR (a Vision-IMU based detection and ranging method)-based approach to road-surface pothole detection. Most potholes on the road surface are caused by the further erosion of cracks in the road surface, and tires, wheels and bearings of vehicles are damaged to some extent as they pass through the potholes. To ensure the safety and stability of vehicle driving, we propose a VIDAR-based pothole-detection method.

Effective fraction of Gualou-Xiebai-Banxia decoction inhibits the apoptosis of myocardial cells induced by ox-LDL via FGF21/FGFR1/βKlotho-FRS2α signal pathway.

Ethnopharmacological Relevance: The Gualou-Xiebai-Banxia decoction (GXBD), a classical traditional Chinese medicine (TCM) formula, has beneficial effects in turbid phlegm obstruction syndrome, a type of coronary heart disease (CHD). However, the underlying mechanism and effective constituents of GXBD remain elusive. Our previous studies have shown that the effective constituents of GXBD may be enriched in the n-butanol fraction (GXB-N) and water fraction (GXB-W), the targets of which remain unknown.

Obstacle Detection Method Based on RSU and Vehicle Camera Fusion.

Road obstacle detection is an important component of intelligent assisted driving technology. Existing obstacle detection methods ignore the important direction of generalized obstacle detection. This paper proposes an obstacle detection method based on the fusion of roadside units and vehicle mounted cameras and illustrates the feasibility of a combined monocular camera inertial measurement unit (IMU) and roadside unit (RSU) detection method.

Tumor-infiltrating lymphocytes provides recent survival information for early-stage HER2-low-positive breast cancer: a large cohort retrospective study.

Purpose: It has been reported that breast cancer (BC) with low expression of human epidermal growth factor receptor 2 (HER2) might be a distinct subtype of BC. However, the prognostic effect of low HER2 expression on BC patients remains controversial. We aim to conduct this single-institution retrospective analysis to assess HER2-low-positive BC outcomes in Chinese women and the prognostic role of TILs in HER2-low-positive early-stage BC.

Asymmetric 2,4-Dienylation/[4 + 2] Annulation Cascade to Construct Fused Frameworks via Auto-Tandem Palladium Catalysis.

A palladium catalyzed tandem reaction between -functionalized aryl enones and 2,4-dienyl carbonates has been presented, proceeding through sequential 2,4-dienylation/Michael addition/π-σ-π isomerization/allylic alkylation. A broad array of enantioenriched architectures having fused and spirocyclic frameworks are constructed in moderate to excellent yields and stereoselectivity. Notably, the intrinsic intramolecular Diels-Alder reaction pattern of the dienylated intermediates is well reversed via Pd(0)-π-Lewis base catalysis.

Enhanced Electroluminescence from a Silicon Nanocrystal/Silicon Carbide Multilayer Light-Emitting Diode.

Developing high-performance Si-based light-emitting devices is the key step to realizing all-Si-based optical telecommunication. Usually, silica (SiO) as the host matrix is used to passivate silicon nanocrystals, and a strong quantum confinement effect can be observed due to the large band offset between Si and SiO (~8.9 eV).

Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction.

Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined.

A Recognition Method for Soft Objects Based on the Fusion of Vision and Haptics.

For humans and animals to recognise an object, the integration of multiple sensing methods is essential when one sensing modality is only able to acquire limited information. Among the many sensing modalities, vision has been intensively studied and proven to have superior performance for many problems. Nevertheless, there are many problems which are difficult to solve by solitary vision, such as in a dark environment or for objects with a similar outlook but different inclusions.

Interface-Enhanced SiO/Ru Heterocatalysts for Efficient Electrochemical Water Splitting.

Developing a bifunctional electrocatalyst with remarkable performance viable for overall water splitting is increasingly essential for industrial-scale renewable energy conversion. However, the current electrocatalyst still requires a large cell voltage to drive water splitting due to the unsuitable adsorption/desorption capacity of reaction intermediates, which seriously hinders the practical application of water splitting. Herein, a unique SiO/Ru nanosheet (NS) material was proposed as a high-performance electrocatalyst for overall water splitting.