SPW-TransUNet: three-dimensional computed tomography-cone beam computed tomography image registration with spatial perpendicular window Transformer.

Background: Current medical image registration methods based on Transformer still encounter challenges, including significant local intensity differences and limited computational efficiency when dealing with three-dimensional (3D) computed tomography (CT) and cone beam CT (CBCT) images. These limitations hinder the precise alignment necessary for effective diagnosis and treatment planning. Therefore, the aim of this study is to develop a novel method that overcomes these challenges by enhancing feature interaction and computational efficiency in 3D medical image registration.

Asynchronous patterns in soil bacterial diversity and functional potentials along an alpine altitudinal gradient.

Introduction: Altitudinal changes in soil bacterial diversity, composition, biotic interactions, and function are prevalent. However, the overall patterns and associations among these dimensions remain unclear, particularly in vulnerable alpine mountain ecosystems.

Methods: Here, we investigated soil bacterial communities along a high-altitude gradient to elucidate patterns and associations in taxonomic and phylogenetic diversity, co-occurrence networks, and functional potentials.

Epimedin C alleviated osteoarthritis development by regulating chondrocyte Nrf2-mediated NLRP3 inflammasome axis.

Osteoarthritis (OA) is a prevalent musculoskeletal disorder globally. This study explored the therapeutic potential of Epimedin C (Epi C) in OA and its mechanisms. We isolated primary chondrocytes from mice and induced inflammatory damage using interleukin-1β (IL-1β) to evaluate Epi C's capacity to preserve cell viability and inhibit apoptosis, employing cell counting kit (CCK8) assays, EdU staining, and flow cytometry.

A Novel Simulation Model of Shielding Performance Based on the Anisotropic Magnetic Property of Magnetic Shields.

To achieve a near-zero magnetic field environment, the use of permalloy sheets with high-performance magnetic properties is essential. However, mainstream welding processes for magnetically shielded rooms (MSRs), such as argon arc welding and laser welding, can degrade the magnetic properties of the material. Additionally, neglecting the anisotropy of permalloy sheets can introduce unpredictable errors in the evaluation of MSR performance.

Classification and prediction of variants associated with hearing loss using sequence information in the vicinity of mutation sites.

Hearing impairment is a major global health problem, affecting more than 5 % of the world's population at various ages, from neonates to the elderly. Among the common genetic variations in humans, single nucleotide variations and small insertions or deletions predominate. The study of hearing loss resulting from these variations is proving invaluable in the analysis and diagnosis of hearing disorders.

Risk Prediction Models for Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Objective: This study aimed to systematically review the existing research on risk prediction models for mild cognitive impairment in patients with type 2 diabetes mellitus and to analyze the predictive performance of these models.

Methods: A systematic computerized search was conducted for studies published in CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane Library, CINAHL, and Web of Science regarding risk prediction models for mild cognitive impairment in patients with type 2 diabetes mellitus, covering the period the inception of the databases through November 10, 2024. Two independent reviewers performed literature screening and data extraction based on predefined inclusion and exclusion criteria.

Airborne Acoustic Vortex End Effector-based Contactless, Multi-mode, Programmable Control of Object Surfing.

Tweezers based on optical, electric, magnetic, and acoustic fields have shown great potential for contactless object manipulation. However, current tweezers designed for manipulating millimeter-sized objects such as droplets, particles, and small animals, exhibit limitations in translation resolution, range, and path complexity. Here, we introduce a novel acoustic vortex tweezers system, which leverages a unique airborne acoustic vortex end effector integrated with a three degree-of-freedom (DoF) linear motion stage, for enabling contactless, multi-mode, programmable manipulation of millimeter-sized objects.

Dual Foot-Mounted Localisation Scheme Employing a Minimum-Distance-Constraint Kalman Filter Under Coloured Measurement Noise.

This study proposes a dual foot-mounted localisation scheme with a minimum-distance-constraint (MDC) Kalman filter (KF) for human localisation under coloured measurement noise (CMN). The dual foot-mounted localisation employs inertial measurement unit (IMUs), one on each foot, and is intended for human navigation. The KF under CMN (cKF) is then derived from the data-fusion model of the proposed navigation scheme.

The effect of circulating tumor DNA on the prognosis of patients with head and neck squamous cell carcinoma: a systematic review and meta-analysis.

Background: Circulating tumour DNA (ctDNA) has emerged as a valuable liquid biopsy biomarker in the field of oncology, including head and neck squamous cell carcinomas (HNSCCs), offering potential insights into cancer diagnosis, progression, and prognosis. This review aims to comprehensively evaluate the utility of ctDNA as a prognostic biomarker in HNSCC.

Methods: PubMed and Ovid were searched as part of our review.

Multiresponsive Ionogel with Switchable Adhesion Triggered by Phase Separation.

The rapid development of wearable devices and soft robotics has an urgent demand for polymer conductors with a switchable adhesion property. Herein, we report a supramolecular ionogel (SIG) that can reversibly switch between adhesion and debonding to various substrates. The on/off switchable adhesion of SIG is attributed to phase separation induced by the aggregation of polymer chains and the formation of a lubricating layer, which impairs the contact between polymer chains and substrates, thus weakening interfacial interaction.

Co-grown novel S-scheme tubular P-UCN/S-TCN homojunction mediates photocatalysis-PMS activation synergistic system for efficient degradation of antibiotic.

The low photogenerated carrier separation and transport ability of the photocatalyst are the main factors inhibiting the photocatalytic activity. The construction of composite photocatalysts can effectively improve the efficiency of photogenerated carriers. However, the problem of reduced photocatalyst stability and catalytic activity due to easy separation of unstable composite interfaces has not been well solved for a long time.

Amyloid fibrils for β-carotene delivery - Influence of self-assembled structures on binding and in vitro release behavior.

Two whey protein isolate amyloid fibrils (WPIF) with different structure were prepared, and the effects of these structures on binding of β-carotene (BC) and in vitro digestibility were evaluated. Whey protein isolate (WPI) in water (80 °C, pH 2.0) self-assembled into elongated WPIF (E-WPIF), whereas WPI formed to worm-like WPIF (W-WPIF) in trifluoroethanol.

Panax Notoginseng Saponins promotes the meningeal lymphatic system-mediated hematoma absorption in intracerebral hemorrhage.

Background: Hematoma clearance is crucial for treating intracerebral hemorrhage (ICH). Currently, there is a lack of pharmacological therapy aimed at promoting hematoma absorption. Meningeal lymphatic system, as a drain of brain, is a potential therapeutic approach in ICH.

Exploring core and bridge symptoms in patients recovering from stroke: a network analysis.

Background: Patients recovering from stroke experience a variety of symptoms that present as a synergistic and mutually reinforcing "symptom cluster," rather than as singular symptoms. In this study, we researched and systematic analyzed these symptom clusters, including core and bridge symptoms, to help determine the relationships between symptoms and to identify key symptom targets, providing a new approach for formulating precise symptom management interventions.

Methods: Convenience sampling was applied to select 432 stroke recovery patients treated in the Seventh People's Hospital of Changzhou City from August 1, 2023 to April 14, 2024.

Identification of a novel 145 kb deletion (Guigang deletion, -) in the alpha-globin gene cluster from a Chinese newborn using third-generation sequencing.

Objective: To describe a novel α-thalassemiadeletion identified from a newborn by third-generation sequencing (TGS).

Case Report: The proband, a newborn subject to neonatal capillary electrophoresis (CE) screening, exhibited suspected α-thalassemia carrier status (Hb Bart's 3.0%).

SubCELL: the landscape of subcellular compartment-specific molecular interactions.

The subcellular compartment-specific molecular interactions (SCSIs) are the building blocks for most molecular functions, biological processes and disease pathogeneses. Extensive experiments have therefore been conducted to accumulate the valuable information of SCSIs, but none of the available databases has been constructed to describe those data. In this study, a novel knowledge base SubCELL is thus introduced to depict the landscape of SCSIs among DNAs/RNAs/proteins.