DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer.

Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. While the increased glycolytic activity rapidly replenished the ATP pool, it did not restore the reduced production of aspartate upon OXPHOS inhibition.

Discovery and Total Synthesis of a New Class of Minor Immunosuppressive Plant Sesterterpenoids.

Plant sesterterpenoids are an extremely rare family of natural products that generally possess novel chemical structures and diverse biological activities. Here, we report the discovery of an unprecedented group of minor plant sesterterpenoids, gracilisoids B-E (2-5), which feature two types of highly functionalized bicyclo[3.2.

Comparisons of Post-Load Glucose at Different Time Points for Identifying High Risks of MASLD Progression.

: The 1-h post-load plasma glucose was proposed to replace the current OGTT criteria for diagnosing prediabetes/diabetes. However, it remains unclear whether it is superior in identifying progressive metabolic dysfunction-associated steatotic liver disease (MASLD), and thus we aimed to clarify this issue. : Consecutive Asian participants (non-MASLD, = 1049; MASLD, = 1165) were retrospectively enrolled between June 2012 and June 2024.

Comparison of Accuracy in Mandible-First and Maxilla-First Approaches in Bimaxillary Orthognathic Surgery: A Meta-Analysis.

This meta-analysis compares the accuracy of mandible-first and maxilla-first approaches in bimaxillary orthognathic surgery to improve clinical decision-making. A systematic search was performed in PubMed, Web of Science, Embase, and Cochrane databases up to August 2024. The analysis included randomized controlled trials and cohort studies with a minimum of 10 patients.

A Bibliometric Review of Software Tools in Plastic Surgery: How They Benefit Surgeons and Improve Practice from 2004 to 2024.

Background: Bibliometric analyses of software applications in plastic surgery are relatively limited. This study aims to address this gap by summarizing current research trends and providing insights that may guide future developments in this field.

Methods: Data were retrieved from the Web of Science Core Collection.

Achieving stable partial nitrification by exploiting lag phase of NOB recovery for selective washout.

Stable inhibition of nitrite-oxidizing bacteria (NOB) is a significant challenge in achieving partial nitrification (PN) and partial nitrification-anaerobic ammonia oxidation (PNA). Growing evidence suggested that NOB can develop resistance to suppression over time, leading to the re-enrichment of NOB within reactors. To address these issues, this study aimed to achieve stable PN by regulating SRT to selectively washout NOB during the lag phase of activity recovery following FA/FNA exposure.

Targeted metals extraction from spent LiNiCoMnO batteries via thermochemical-induced sulfation roasting: Thermodynamics & kinetics.

To alleviate the energy crisis and control environmental pollution raised by spent lithium-ion batteries (LIBs), the development of efficient and economic methods for their recycling is crucial for sustainable development of new energy industry. Herein, a combined pyro - hydrometallurgical process was adopted for recovery of valuable metal elements for spent LiNiCoMnO (NCM523). Different from conventional pyrometallurgical methods with high temperature and energy consumption, the NHHSO roasting strategy works at 400 °C and achieves remarkable leaching efficiencies of Li, Co, Mn, and Ni achieved 97.

Erratum: Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells: Erratum.

[This corrects the article DOI: 10.7150/thno.63763.

Magnesium Oxide-Supported Single Atoms with Fine-Modulated Steric Location for Polymerization Transfer Removal of Water Pollutants.

Organic pollutants removal via a polymerization transfer (PT) pathway based on the use of single-atom catalysts (SACs) promises efficient water purification with minimal energy/chemical inputs. However, the precise engineering of such catalytic systems toward PT decontamination is still challenging, and the conventional SACs are plagued by low structural stability of carbon material support. Here, we adopted magnesium oxide (MgO) as a structurally stable alternative for loading single copper (Cu) atoms to drive peroxymonosulfate-based Fenton-like reactions.

Applying 1-hour postload plasma glucose diagnostic criteria reveals high Progressive Risks of potential MASLD.

Background: Recently, a 1-h PG value of ≥ 8.6 mmol/L, a more sensitive predictor of diabetes mellitus-related long-term cardiovascular complications than routine glucose markers, has been recommended as an additional diagnostic criterion for diabetes in the International Diabetes Federation Position Statement. However, its value in MASLD remains uncertain.

The small molecule peptide ANXA114-26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor.

Chemo-resistance in ovarian cancer is currently a major obstacle to the treatment and recovery of ovarian cancer. Therefore, identifying factors associated with chemo-resistance in ovarian cancer may reverse chemo-sensitization. Using isobaric tags for relative and absolute quantitation (ITRAQ) technology, we found a small molecule peptide with annexin 1 (ANXA1) as a precursor protein.

Graphitic Carbon Nitride Confers Bacterial Tolerance to Antibiotics in Wastewater Relating to ATP Depletion.

Graphitic carbon nitride (CN) is a kind of visible light-responsive photocatalyst that has been of great interest in wastewater treatment. However, its environmental impact and biological effect remains to be elucidated. This study investigated the effect of CN nanosheets on bacterial abundance and antibiotic tolerance in wastewater.

Classification and prediction of variants associated with hearing loss using sequence information in the vicinity of mutation sites.

Hearing impairment is a major global health problem, affecting more than 5 % of the world's population at various ages, from neonates to the elderly. Among the common genetic variations in humans, single nucleotide variations and small insertions or deletions predominate. The study of hearing loss resulting from these variations is proving invaluable in the analysis and diagnosis of hearing disorders.

Mn-based tunnel-structured NaMnO cathode materials for high-performance sodium-ion batteries: electrochemical mechanism, synthesis and modifications.

Sodium-ion batteries (SIBs) have emerged as promising and mature alternatives to lithium-ion batteries (LIBs) in the post-LIB era, necessitating the development of cost-effective and high-performance cathode materials. The unique crystal texture of Mn-based tunnel-structured cathode materials offers outstanding cycling stability, rate capability and air stability, making them a highly attractive option for sodium-ion storage applications. This comprehensive review summarizes recent advancements in the understanding of sodium-ion storage mechanism, synthesis techniques, and modification strategies for Mn-based tunnel-structured cathode materials, thereby significantly contributing to the advancement of high-performance cathodes for SIBs.

Enhancing resistance to in yellow-feathered broilers: a study of a strain of as probiotic feed additives.

strains are potentially rich sources of probiotics that could help avoid infections. In order to evaluate their efficacy in bolstering resistance to infection among chicks. In this study, and commercial probiotics were administered via the water supply at a dosage of 1×10 CFU per chicken from days 1 to 7 to establish a protective system for the chicks.

Prospective changes in financial toxicity and health-related quality of life in patients with gynecologic cancer.

Background: Financial toxicity impacts the treatment choices, daily life, and health-related quality of life (HRQoL) of cancer patients. We investigated future variations in financial toxicity and HRQoL of patients with gynecologic cancer, evaluated using the COmprehensive Score for financial Toxicity (COST) questionnaire.

Methods: This multicenter study enrolled patients with gynecologic cancer incurring co-payments for anti-cancer drug treatment for over 2 months.

Heterogeneity of pain-fatigue-sleep disturbance symptom clusters in lung cancer patients after chemotherapy: a latent profile analysis.

Purpose: Pain-fatigue-sleep disturbance symptom cluster (PFS) was common in patients with lung cancer and seriously affected the life quality of patients. However, the heterogeneity and subgroups of PFS were unclear in lung cancer patients after chemotherapy. This study was conducted to identify distinct subgroups of PFS in patients with lung cancer after chemotherapy, and explore the differences and risk factors of PFS subgroups.

Optimization of ultrasound-mediated DNA transfer for bacteria and preservation of frozen competent cells.

Unlabelled: The transformation of DNA into cells is the basis of molecular biology. Commonly employed techniques include heat shock transformation, electro-transformation, conjugation, transduction, and protoplast fusion. Recently, ultrasonic transformation technology has been developed to transfer DNA into competent cells.

Biodegradable and Implantable Triboelectric Nanogenerator Improved by β-Lactoglobulin Fibrils-Assisted Flexible PVA Porous Film.

Triboelectric nanogenerators (TENGs) are highly promising as implantable, degradable energy sources and self-powered sensors. However, the degradable triboelectric materials are often limited in terms of contact electrification and mechanical properties. Here, a bio-macromolecule-assisted toughening strategy for PVA aerogel-based triboelectric materials is proposed.

Silencing CXCR6 promotes epithelial-mesenchymal transition and invasion in colorectal cancer by activating the VEGFA/PI3K/AKT/mTOR pathway.

This study investigated the role of C-X-C motif chemokine receptor 6 (CXCR6) in colorectal cancer (CRC). It was found that lower CXCR6 expression is correlates with poorer prognostic outcomes, suggesting that CXCR6 may inhibit tumor progression and thus improve patient outcomes. Silencing CXCR6 in CRC cell lines SW620 and CT-26 resulted in significantly enhanced migration and invasion, as demonstrated by wound healing and transwell assays.

Effect of the HCT Gene on Lignin Synthesis and Fiber Development in Gossypium barbadense.

As one of the key enzymes in the metabolic pathway of phenylpropane, shikimate hydroxycinnamoyl transferase (HCT) is mainly involved in the biosynthesis of the plant secondary cell wall, which is closely related to cotton fiber quality. In this study, whole-genome identification and bioinformatics analysis of the HCT gene family were performed in G. barbadense.

Alleviates Inflammatory Response, Apoptosis, and ECM Degradation in Osteoarthritic Chondrocytes by Stabilizing .

Background: It has been reported that Sirtuin 2 () prevents phosphoenolpyruvate carboxykinase 1 () degradation, which can be involved in aging-induced osteoarthritis (OA), but the molecular mechanism of / in chondrocytes has not been clarified. Therefore, this study aims to explore the mechanism of / in chondrocyte inflammation.

Method: To establish the OA model , chondrocytes cultured with interleukin-1β (IL-1β, 10 ng/mL) and manipulation of and expression in the constructed cells to elucidate the interaction between the two genes.

Exercise preconditioning mitigates Ischemia-Reperfusion injury in rats by enhancing mitochondrial respiration.

Cerebral ischemia and subsequent reperfusion damage are prevalent in clinical practice, linked to numerous neurodegenerative diseases. Cerebral ischemia deprives brain tissue of essential oxygen and nutrients, disrupting energy metabolism and causing cellular dysfunction. Although reperfusion theoretically aids recovery, it instead initiates complex injury responses such as oxidative stress, apoptosis, and inflammation, worsening brain damage.