Construction of Highly Porous and Robust Hydrogen-Bonded Organic Framework for High-Capacity Clean Energy Gas Storage.

Development of highly porous and robust hydrogen-bonded organic frameworks (HOFs) for high-pressure methane and hydrogen storage remains a grand challenge due to the fragile nature of hydrogen bonds. Herein, we report a strategy of constructing the double-walled framework to target highly porous and robust HOF (ZJU-HOF-5a) for extraordinary CH and H storage. ZJU-HOF-5a features a minimized twofold interpenetration with double-walled structure, in which multiple supramolecular interactions are existed between the interpenetrated walls.

Efficacy of neuroendoscopic-assisted surgery in the management of symptomatic sacral perineural (Tarlov) cysts: a technical report.

Introduction: The Tarlov cysts are pathological enlargements of the cerebrospinal fluid spaces between the endoneurium and perineurium, which can cause intolerable sciatic pain, motor impairment of lower limbs, and bladder/bowel dysfunction. Currently, the treatment results are unsatisfactory due to the low cure rates and extensive surgical trauma. Thus, there is an ongoing exploration of surgical techniques for Tarlov treatment.

Syringo-Subarachnoid Shunt with Tube Versus T-Tube via the Dorsal Root Entry Zone Approach for Eccentric Syringomyelia.

Objective: This study compared the clinical therapeutic efficacy of syringo-subarachnoid shunt placement with direct tube and T-tube via the dorsal root entry zone (DREZ) approach for treatment of eccentric syringomyelia.

Methods: A retrospective study was performed of 41 patients with idiopathic or secondary eccentric syringomyelia from November 2011 to December 2022. Syringo-subarachnoid shunt placement with direct tube or T-tube via the DREZ approach was performed.

6-Methoxydihydrosanguinarine exhibits cytotoxicity and sensitizes TRAIL-induced apoptosis of hepatocellular carcinoma cells through ROS-mediated upregulation of DR5.

6-methoxydihydrosanguinarine (6-MS), a natural benzophenanthridine alkaloid extracted from Macleaya cordata (Willd.) R. Br, has shown to trigger apoptotic cell death in cancer cells.

Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study.

Objective: To identify specific Chinese medicines (CMs) that may benefit patients with gastroesophageal reflux disease (GERD), and explore the action mechanism.

Methods: Domestic and foreign literature on the treatment of GERD with CMs was searched and selected from China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and PubMed from October 1, 2011 to October 1, 2021. Data from all eligible articles were extracted to establish the database of CMs for GERD.

Invention of a non-invasive intracranial pressure (ICP) monitoring system - an enlightenment from a hydrocephalus study.

Background: Mechanical obstruction is the most common cause of shunt failure for hydrocephalic patients. However, the diagnosis is extremely challenging and often requires invasive testing methods. Thus, a simple and non-invasive technique is in urgent need to predict the intracranial pressure (ICP) of hydrocephalic patients during their post-surgical follow-up, which could help neurosurgeons to determine the conditions of the shunt system.

The effect of gemcitabine combined with AMD3100 applying to cholangiocarcinoma RBE cell lines to CXCR4/CXCL12 axis.

Purpose: To evaluate the effect of AMD3100 treatment to cholangiocarcinoma by analyzing the relationship between them, and provide experimental evidence for whether AMD3100 can become a clinical treatment drug for cholangiocarcinoma.

Materials And Methods: Cholangiocarcinoma RBE cell lines were used in this study. MTT cell proliferation test was used for evaluating the effect of gemcitabine and AMD3100 to cell.

IL-34 regulates the inflammatory response and anti-bacterial immune defense of Japanese flounder Paralichthys olivaceus.

Interleukin (IL)-34 is a relatively recently discovered cytokine with pleiotropic effects on various cellular activities, including immune response. In fish, the knowledge on the function of IL-34 is limited. In the present work, we investigated the function of Japanese flounder Paralichthys olivaceus IL-34 (PoIL-34) in association with inflammation and immune defense.

Effect of Nitrogen Flow Ratio on Composition, Microstructure, and Mechanical Properties of Cr-B-O-N Films Deposited by Pulsed Direct Current Magnetron Sputtering.

Nano-crystalline CrB₂ and Cr-B-O-N films with various nitrogen flow ratios were deposited using a pulsed direct current (PDC) magnetron sputtering technique. By means of electron probe micro-analysis, X-ray diffraction (XRD), X-ray photoelectron spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy (HRTEM), and atomic force microscopy, the influences of the nitrogen flow ratio on the phase constituents and microstructures of CrB₂/Cr-B-O-N films were systematically investigated. Mechanical properties including the hardness and elastic modulus were explored by a nano-indentation tester.

Influence of Cu Content on the Microstructure and Mechanical Properties of Cr-Cu-N Coatings.

The Cr-Cu-N coatings with various Cu contents (0-25.18 (±0.17) at.

Biomechanical Influences of Transcorporeal Tunnels on C4 Vertebra Under Physical Compressive Load Under Flexion Movement: A Finite Element Analysis.

Background: Anterior percutaneous endoscopic transcorporeal cervical discectomy is an alternative operation for cervical disc herniation. However, few reports have evaluated the biomechanical influence of tunnels on vertebrae. We compared biomechanical distinctions between intact and tunneled models of vertebrae to analyze the safety of anterior percutaneous endoscopic transcorporeal cervical discectomy based on a C2-T1 finite element (FE) model.

Enhanced Corrosion Resistance of PVD-CrN Coatings by ALD Sealing Layers.

Multilayered hard coatings with a CrN matrix and an AlO, TiO, or nanolaminate-AlO/TiO sealing layer were designed by a hybrid deposition process combined with physical vapor deposition (PVD) and atomic layer deposition (ALD). The strategy was to utilize ALD thin films as pinhole-free barriers to seal the intrinsic defects to protect the CrN matrix. The influences of the different sealing layers added in the coatings on the microstructure, surface roughness, and corrosion behaviors were investigated.

Broadband photodetector based on carbon nanotube thin film/single layer graphene Schottky junction.

In this study, we present a broadband nano-photodetector based on single-layer graphene (SLG)-carbon nanotube thin film (CNTF) Schottky junction. It was found that the as-fabricated device exhibited obvious sensitivity to a wide range of illumination, with peak sensitivity at 600 and 920 nm. In addition, the SLG-CNTF device had a fast response speed (τ = 68 μs, τ = 78 μs) and good reproducibility in a wide range of switching frequencies (50-5400 Hz).

Graphene-β-Ga O Heterojunction for Highly Sensitive Deep UV Photodetector Application.

A deep UV light photodetector is assembled by coating multilayer graphene on beta-gallium oxide (β-Ga O ) wafer. Optoelectronic analysis reveals that the heterojunction device is virtually blind to light illumination with wavelength longer than 280 nm, but is highly sensitive to 254 nm light with very good stability and reproducibility.

PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis in leukemia cells.

LF11-322 (PFWRIRIRR-NH2) (PFR peptide), a nine amino acid-residue peptide fragment derived from human lactoferricin, possesses potent cytotoxicity against bacteria. We report here the discovery and characterization of its antitumor activity in leukemia cells. PFR peptide inhibited the proliferation of MEL and HL-60 leukemia cells by inducing cell death in the absence of the classical features of apoptosis, including chromatin condensation, Annexin V staining, Caspase activation and increase of abundance of pro-apoptotic proteins.

Efficient optical image amplifier using periodically poled lithium niobate.

An efficient optical image amplification scheme has been proposed and demonstrated using the quasi-phase-matched optical parametric amplifier. Pumped with the 152 μJ per pulse pump laser at 532 nm, the input weak infrared image at 1064 nm with 3.5 pJ energy is amplified with a 55 dB optical gain using only a 3 mm long MgO-doped periodically poled lithium niobate (MgO:PPLN) crystal.

Improved Corrosion Resistance and Mechanical Properties of CrN Hard Coatings with an Atomic Layer Deposited Al2O3 Interlayer.

A new approach was adopted to improve the corrosion resistance of CrN hard coatings by inserting a Al2O3 layer through atomic layer deposition. The influence of the addition of a Al2O3 interlayer, its thickness, and the position of its insertion on the microstructure, surface roughness, corrosion behavior, and mechanical properties of the coatings was investigated. The results indicated that addition of a dense atomic layer deposited Al2O3 interlayer led to a significant decrease in the average grain size and surface roughness and to greatly improved corrosion resistance and corrosion durability of CrN coatings while maintaining their mechanical properties.

The host HLA-A*02 allele is associated with the response to pegylated interferon and ribavirin in patients with chronic hepatitis C virus infection.

Human leukocyte antigen (HLA) alleles are associated with both the progression of chronic hepatitis C (CHC) and the sustained virological response (SVR) to antiviral therapy. HLA-A*02 is the most common HLA allele in people of European/Caucasian descent and the Chinese and Japanese population. Therefore, we investigated whether HLA-A*02 expression is associated with disease outcome in Chinese CHC patients.

Selective depletion of regulatory T cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer.

Regulatory T (Treg) cells are potent suppressors that maintain immune homeostasis. Accumulation of Treg can inhibit effective immune responses in cancer patients, leading to tumor development and progression. Despite direct cytotoxicity, several chemotherapeutic drugs have been reported to deplete Treg cells for better prognosis for cancer patients.

Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.

Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.

[Fine root biomass and carbon storage in surface soil of Cinnamomum camphora plantation in rainy area of West China].

Fine root in forest ecosystems plays an important role in global C cycle. In this study, a measurement was made on the fine root biomass and carbon storage in the surface soil (0-30 cm) of a 31 year-old Cinnamomum camphora plantation in the Rainy Area of West China in November, 2010-December, 2011. The total biomass and carbon storage of the fine roots (living and dead) in the surface soil were 1592.

Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma.

Background: Mucous hypersecretion increases asthma morbidity and mortality. Tumor necrosis factor a (TNF-a) levels are elevated in bronchoalveolar fluid, sputum, and monocyte membranes in some patients with asthma. Anti-TNF-a decreased asthma exacerbations and improved forced expiratory volume in 1 second in these patients.

RbAp46 inhibits estrogen-stimulated progression of neoplastigenic breast epithelial cells.

Background: Despite widespread agreement that estrogens are involved in the etiology of human breast cancer, there is uncertainty as to the molecular mechanisms of estrogen action in early development of breast cancer.

Materials And Methods: MCF10AT3B cells, a cell line derived from a xenograft model of human proliferative breast disease, were used to study the estrogen-stimulated malignant progression of neoplastigenic mammary epithelial cells. A stable cell line was established from MCF10AT3B cells that ectopically expresses the retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46), a component of the histone modifying and remodeling complexes.

Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice.

Background: The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized.

Objective: To evaluate lung inflammation, mucus metaplasia and AHR in relationship with age in murine models of allergic asthma comparing young and older mice.

Methods: Young (6 weeks) and older (6, 12, 18 months) BALB/c mice were sensitized and challenged with ovalbumin (OVA).