Investigating Causal Links Between Gut Microbiota and Neurological Disorders via Genome-Wide Association Studies.

Many reports have highlighted the involvement of the gut microbiome in the occurrence, progression, and outcomes of neurological disorders. However, current reports are somewhat chaotic, especially concerning whether the gut microbiota has a causal effect on various neurological diseases. Furthermore, whether there is a common mechanism involving gut microbial communities in these neurological disorders has not to be revealed.

Traditional Chinese Medicine for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

The treatment of Alzheimer's Disease (AD) remains a challenge for modern medicine due to its complex pathogenesis. Traditional Chinese Medicine (TCM) has demonstrated significant success in the prevention and treatment of variable medical conditions. For AD pharmacological management, TCM could provide promising approaches.

Forensic age estimation using Vieth classification in adolescents of northern China based on the knee MRI.

To investigate the applicability of the Vieth classification and characteristics of ossification age in knee joint in adolescents of northern China. A retrospective study was conducted on a total of 1517 MRI images of knee joints from patients aged 10 to 20 years in the northern China. Vieth classification was used to assess the ossification age of distal femur and proximal tibia.

The Bidirectional Relations Between Parental Autonomy Support, Gratitude and Academic Engagement in Chinese Adolescents.

Abundant evidence highlights the benefits of self-determined motivation (e.g., parental autonomy support as internalized extrinsic motivation, gratitude as intrinsic motivation) on academic engagement during adolescence, yet the potential mutual relations remain relatively unexplored.

TiN Boosting the Oxygen Reduction Performance of Fe-N-C through the Relay-Catalyzing Mechanism for Metal-Air Batteries.

Metal-air batteries desire highly active, durable, and low-cost oxygen reduction catalysts to replace expensive platinum (Pt). The Fe-N-C catalyst is recognized as the most promising candidate for Pt; however, its durability is hindered by carbon corrosion, while activity is restricted due to limited oxygen for the reaction. Herein, TiN is creatively designed to be hybridized with Fe-N-C (TiN/Fe-N-C) to relieve carbon corrosion and absorb more oxygen when catalyzing oxygen reduction.

Novel Meningoencephalomyelitis Associated With Vimentin IgG Autoantibodies.

Importance: Autoantibodies targeting astrocytes, such as those against glial fibrillary acidic protein (GFAP) or aquaporin protein 4, are crucial diagnostic markers for autoimmune astrocytopathy among central nervous system (CNS) autoimmune disorders. However, diagnosis remains challenging for patients lacking specific autoantibodies.

Objective: To characterize a syndrome of unknown meningoencephalomyelitis associated with an astrocytic autoantibody.

3D-Porous Electrocatalyst with Tip-Enhanced Electric Field Effect Enables High-Performance Proton Exchange Membrane Water Electrolyzer.

Hydrogen evolution reaction (HER), as one of the most advanced methods for the green production of hydrogen, is greatly impeded by inefficient mass transfer. Here we present an efficiently reactant enriched and mass traffic system by integrating high-curvature Pt nanocones with 3D porous TiAl framework to enhance mass transfer rate. Theoretical simulations, in situ Raman spectroscopy and potential-dependent Fourier transform infrared spectroscopy results disclose that the strong local electric field induced by high-curvature Pt can greatly promote the HO supply rate during HER, resulting in ∼1.

Newcastle Disease Virus-Vectored African Swine Fever Virus Antigen Cocktail Delays the Onset of ASFV-SY18 but Is Not Protective.

African Swine Fever (ASF) is a highly contagious viral disease threatening the global pig industry. Currently, only two gene-deleted live attenuated vaccines are approved, exclusively in Vietnam, and their long-term effectiveness and safety are unproven, prompting the need for safer alternatives. This study assessed a cocktail of African Swine Fever Virus (ASFV) antigens delivered via a recombinant Newcastle Disease Virus (rNDV) vector against the genotype II ASFV-SY18.

High Performance of CsAgBiBr Perovskite-based Photodetectors by Adding DEAC.

Perovskite-based photodetectors (PDs) are broadly utilized in optical communication, non-destructive testing, and smart wearable devices due to their ability to convert light into electrical signals. However, toxicity and instability hold back their mass production and commercialization. The lead-free CsAgBiBr double perovskite film, promised to be an alternative, is fabricated by electrophoretic deposition (EPD), which compromises film quality.

An intracranial yolk sac tumor with initial symptom of hemorrhage in the basal ganglia: a case report.

We report a case and follow-up of an adult male with intracranial yolk sac tumor (YST). Initially, the patient presented with abnormal high signals in the right basal ganglia on MRI, misdiagnosed as a cavernous hemangioma. However, within 2 years, the condition rapidly progressed into a large, hypervascular solid neoplasm leading to a basal ganglia hemorrhage.

Global, Regional and National Burden of Maternal Obstructed Labour and Uterine Rupture, 1990-2021: Global Burden of Disease Study 2021.

Background: Maternal obstructed labour and uterine rupture (MOLUR) are among the major maternal labour complications that threaten maternal and child health.

Objective: The objective of this study was to systematically analyse the global burden of MOLUR using the Global Burden of Disease 2021 (GBD 2021) database to inform further improvements in maternal-related public health policies.

Methods: Incidence and disability-adjusted life-year (DALY) data on MOLUR from 1990 to 2021 were collected in the GBD 2021.

Bergapten Ameliorates Psoriatic Skin Lesions and IL-17A-Induced Activation of the NF-κB Signaling Pathway via the Downregulation of CYP1B1.

Bergapten (BP) is a plant-derived furocoumarin that has a wide range of pharmacological effects. BP serves as a candidate amplifier in phototherapy against skin inflammation, such as psoriasis and atopic dermatitis. However, the anti-inflammatory role of BP remains elusive.

Robust Multifunctional Films with Excellent EMI Shielding, Anti-Peeling, and Joule Heating Performances Enabled by an Encapsulated Highly Conductive Fabric Strategy.

Recently, the issue of electromagnetic pollution has become increasingly prominent. Flexible polymer films with various conductive fillers are preferred to address this problem due to their highly efficient and durable electromagnetic interference (EMI) shielding performance. However, their applications are restricted by the unbalanced and insufficient electromagnetic wave absorption and shielding capabilities, as well as the weak interlayer bonding force.

Integrated Catalyst ZnNC⊂PtZn for High-Performance Ethanol Electrooxidation and DEFC.

We report here an electrocatalyst that exhibits superior performance in the electrooxidation of ethanol. The reactive centers of the catalyst have a nest-type configuration with outer Zn-NC nest covering inner PtZn intermetallic compound nanoparticles loaded on carbon support (ZnNC⊂PtZn/C). The high-energy stepped facets of the inner PtZn nanoparticles confined and shaped by the outer Zn-NC nest is highly active for the critical C-C bond cleavage of ethanol in oxidation, confirmed by experimental characterizations and density functional theory calculations.

Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula.

Persistent pain frequently precipitates the development of anxiety disorders, yet the underlying mechanisms are not fully understood. In this study, we employed a mouse model that simulates trigeminal neuralgia and observed a marked reduction in the activity of GABAergic neurons in the lateral habenula (LHb), a critical region for modulating pain and anxiety. We utilized precise optogenetic and chemogenetic techniques to modulate these neurons, which significantly alleviated behaviors associated with pain and anxiety.

Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization.

Schizophrenia (SCZ) is a complex psychiatric disorder presenting challenges for characterization. The current study aimed to identify and evaluate disease-responsive essential genes (DREGs) to enhance the molecular characterization of SCZ. RNA-sequencing data from PsychENCODE (536 SCZ patients, 832 controls) and peripheral blood transcriptome data from 144 recruited subjects (59 SCZ patients, 6 non-SCZ psychiatric patients, 79 controls) are analyzed.

Dopamine D3 receptor mediates natural and methamphetamine rewards via regulating the expression of miR-29c in the nucleus accumbens of mice.

The dopamine D3 receptor (D3R), principally confined to the nucleus accumbens (NAc), is involved in regulating natural and drug rewards; however, the molecular mechanisms underlying the associated process remain unclear. Earlier research has reported the concurrent influence of D3R and miR-29c expressed in the NAc on methamphetamine (METH)-induced reward behaviors and microglial activation, hinting at regulatory roles in reward processing. Herein, we performed viral manipulation-mediating D3R/miR-29c overexpression and inhibition in the whole NAc in male D3R knockout and wild-type mice to investigate this potential relationship.

Apigenin inhibits lipid metabolism of hepatocellular carcinoma cells by targeting the histone demethylase KDM1A.

Background: The development of cancer is accompanied by metabolic reprogramming, and the liver serves as a central hub for lipid transportation. Apigenin, a plant-derived flavonoid, demonstrates potent anticancer properties across various cancer types and exhibits promising potential as a therapeutic agent for cancer treatment. However, there are limited studies focusing on the downstream targets of apigenin.

Protection Evaluation of a New Attenuated ASFV by Deletion of the and Genes against Homologous Challenge.

African swine fever (ASF) is an acute infectious disease with a high mortality rate in both domestic and wild boars. Commercial vaccines or antiviral drugs for ASF were not available due to the complex diversity of the structure and genome of its pathogen African swine fever virus (ASFV). In recent years, there have been many reports on candidate strains of attenuated vaccines for ASFV.

Altered structural node of default mode network mediated general cognitive ability in young adults with obesity.

Background: Obesity, characterized by excessive adiposity, is associated with brain structural abnormalities. Nevertheless, the relationships between altered structural nodes of default mode network (DMN), body mass index (BMI), general cognitive ability remained unclear in young adults.

Methods: In this study, we divided a large sample of young adults into three BMI-based groups.

Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway.

Introduction: Almonertinib is an important third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) exhibiting high selectivity to EGFR-sensitizing and T790M-resistant mutations. Almonertinib resistance is a major obstacle in clinical use. Baicalein possesses antitumor properties, but its mechanism of antitumor action against almonertinib-resistant non-small cell lung cancer (NSCLC) remains unelucidated.