Chemical investigation of the Liuweizhiji Gegen-Sangshen oral liquid afforded one new diphenyl ether derivative (1), together with one known compound (2). Their structures were established by 1D and 2D NMR, and HR-ESI-MS spectroscopic analysis and the absolute configuration of 1 was confirmed by ECD calculation. Compounds 1 and 2 were evaluated for the cytotoxic activities, and compounds 1 and 2 showed weak cytotoxic activities towards HepG2 human liver cancer cells, with IC values of 97.
View Article and Find Full Text PDFTwo new alkaloids, named migenomycin I (1) and II (2), along with nine known compounds (3-11), were isolated from the fungus Rhizopus oryzae from Atractylodes macrocephala Koidz. The structures of compounds 1 and 2 were determined by spectroscopic methods (MS, NMR, and CD). All compounds were isolated from Rhizopus oryzae for the first time.
View Article and Find Full Text PDFChemical epigenetic cultivation of the sponge-derived fungus sp. SWMU-WZ04-1 contributed to the identification of twelve polyketide derivatives, including six new pestalotiopols E-J (-) and six known analogues (-). Their gross structures were deduced from 1D/2D NMR and HRESIMS spectroscopic data, and their absolute configurations were further established by circular dichroism (CD) Cotton effects and the modified Mosher's method.
View Article and Find Full Text PDFFive undescribed polyketide derivatives, pestaloketides A-E (-), along with eleven known analogues (-), were isolated from the sponge-derived fungus sp. Their structures, including absolute configurations, were elucidated by analyses of NMR spectroscopic HRESIMS data and electronic circular dichroism (ECD) calculations. Compounds , , , and exhibited weak cytotoxicities against four human cancer cell lines, with IC values ranging from 22.
View Article and Find Full Text PDF