Formulation and clinical evaluation of carbidopa/levodopa oral solution for the treatment of sepiapterin reductase deficiency.

Background: sepiapterine reductase deficiency (SRD) is a rare levodopa (L-dopa)-responsive disorder treated with a combination therapy of controlled-release L-dopa and carbidopa. The currently available formulation of controlled-release carbidopa/L-dopa does not entirely meet the requirements for the long-term therapy in pediatric patients. In fact, administration of a manufactured tablet at a dose intended for adults necessitates its adjustment to the child's needs, as the splitting of the tablet into smaller portions or its dilution in water.

The relationship between dyadic adjustment and psychiatric symptomatology in expectant couples: An actor-partner interdependency model approach.

Background: Many researchers who evaluated psychological distress during the transition to parenthood agree in identifying pregnancy as the most sensitive period for the onset of psychiatric symptomatology for both parents. Furthermore, research highlights a correlation between symptoms experienced by fathers in relation to those experienced by mothers.

Objective: The aim of this study was to investigate whether dyadic functioning influences the level of psychiatric symptomatology in couples expecting their first child.

Formulation and Clinical Evaluation of Sodium Benzoate Oral Solution for the Treatment of Urea Cycle Disorders in Pediatric Patients.

Background: Sodium benzoate, a common food preservative, is used in the treatment of patients with urea cycle disorders (UCDs) as it stimulates ammonia removal by a non-urea cycle-based pathway. Despite its use in the clinical routine, no commercially available oral formulations currently exist. Liquid formulation is normally well accepted in pediatric age and allows precise dosage according to the children's needs.

Infantile cerebellar thrombosis: a case of lupus anticoagulants?

Lupus Anticoagulants (LA) pathology is a disease frequently associated with venous and/or arterial thrombosis. The authors describe a 6 year-old boy complaining cephalea and emesis, followed by lethargy, in whom antiphospholipids antibodies were detected. Brain magnetic resonance scans showed lesions of the cerebellum.

[Hospital experience in active immunoprophylaxis against HBV].

According to the Ministry of Health, at the paediatric section of Central Hospital of Rovigo, a vaccination campaign against HBV was undertaken in the year 1985 with the main purpose to reduce the sickness-rate and the mortality by HBV. Two vaccination patterns have been applied and they show to be efficient. 46 risk-subjects divided into two groups were vaccinated: group A: newborn, sons of women HBc Ag positive; group B: children living together with carriers or subjects sick of hepatitis B.

[2 cases of Potter's syndrome].

In this report, we describe two patients with Potter's syndrome classical signs and take the opportunity to discuss about the etiopathogenetic hypothesis concerning various phenotypical expressions of that syndrome.

Serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase activity in premature and full-term asphyxiated newborns.

The serum activity of SGOT and SGPT is one of the more specific parameters of liver cell injury both in adults and in the pediatric age-group. The determination of serum transaminase activity could offer a routine and rapid laboratory test for establishing the presence of hepatic cellular damage following intrauterine or perinatal asphyxia. In fact, it appears that there is a correlation between hypoxia and the increase in serum activity of transaminases in full-term and premature asphyxiated newborns.

[Treatment of diaphragmatic paralysis in the newborn infant].

The paralysis of the diaphragm in the newborn is a rare pathological event. The "paradoxical movement" of the affected emidiaphragm can sometimes determine a important respiratory insufficiency. Medical treatment involves supplying oxygen, CPAP by means of a nasal cannula or mechanical ventilation with PEEP.

[Development of the sympatoadrenergic function in the fetus and the newborn infant].

An analysis of the available data concerning the events bringing to the completion of the adrenergic function in early life shows the existence of an early response making the detection of MOPEG-SO4 levels in the urine--the foetus and in the new-born. This response isn't the same in the adult and in the infant as in the latter the number of receptors is lower, the prevalent mediator is NA and the receptorial subtype is almost entirely beta. The effector system, on the contrary, is as fully developed in the infant as it's in the adult.