Publications by authors named "Templin C"
Emerging evidence suggests the role of mechanical circulatory support (MCS) devices in the therapy of refractory cardiogenic shock (CS). However, largerandomized trials addressing the role of Impella in the therapy of infarct-associated CS are sparse. As such, evidence coming from comprehensive retrospective studies or meta-analyses is of major importance in order to clarify the role of the Impella device in this setting.
View Article and Find Full Text PDFBackground: The impact of sodium-glucose cotransporter-2 (SGLT2) inhibitors on mortality following myocardial infarction (MI) remains uncertain. Additionally, the role of type 2 diabetes mellitus (T2DM) and heart failure (HF) in modulating the effectiveness of these drugs post-MI are not fully understood. This meta-analysis aimed to assess the association of SGLT2 inhibitors with all-cause mortality in post-MI patients and to explore key moderators influencing this benefit.
View Article and Find Full Text PDFBackground: Coronary artery ectasias and aneurysms (CAE/CAAs) are among the less common forms of coronary artery disease, with undefined long-term outcomes and treatment strategies.
Aims: To assess the clinical characteristics, angiographic patterns, and long-term outcomes in patients with CAE, CAA, or both.
Methods: This 15-year (2006-2021) retrospective single-centre registry included 281 patients diagnosed with CAE/CAA via invasive coronary angiography.
Aims: Sodium-glucose co-transporter inhibitors (SGLTis) have cardiovascular protective effects. We aimed to assess the effects of SGLTis on individual hard clinical endpoints and quality of life (QoL) in patients with cardiovascular risk factors.
Methods And Results: Data was searched in PubMed, Embase, Cochrane Library and clinicaltrials.
Article Synopsis
- The procedure faces challenges including unique heart anatomy, catheter instability, and pinpointing the arrhythmia's origin.
- The study combined transthoracic echocardiography (TTE) with 3D mapping to improve localization and successfully ablate PVCs originating from the papillary muscles.
Cardiovascular alterations are common in patients who had ischaemic stroke, haemorrhagic stroke and other acute brain disorders such as seizures. These cardiac complications are important drivers of morbidity and mortality and comprise blood-based detection of cardiomyocyte damage, ECG changes, heart failure and arrhythmia. Recently, the concept of a distinct 'stroke-heart syndrome' has been formulated as a pathophysiological framework for poststroke cardiac complications.
View Article and Find Full Text PDFArticle Synopsis
- * This study analyzed data from over 900 high-risk AF patients to compare outcomes between those receiving LAAO and those getting traditional treatment (mostly oral anticoagulants).
- * Results showed no significant differences in stroke or cardiovascular death rates, but LAAO patients experienced significantly less clinically relevant bleeding compared to those on conventional treatments.
Article Synopsis
- The study investigates the significance of cardiac troponin (cTn) levels in predicting mortality in patients with Takotsubo syndrome (TTS), analyzing data from the International Takotsubo Registry.
- It identifies that a cTn increase greater than 28.8 times the upper reference limit signals clinically relevant myocardial injury, correlating with a higher risk of mortality over 5 years (adjusted HR 1.58).
- The findings enhance understanding of patient risk profiles in TTS, emphasizing the need for increased monitoring and follow-up for those with significant troponin elevations.
Article Synopsis
- The study explored the link between initial body temperature (BT) and 1-year risk of major adverse cardiovascular events (MACE) in patients with acute coronary syndromes (ACS), particularly comparing ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS).
- A total of 1044 ACS patients were analyzed, revealing that while BT did not predict MACE for STEMI, a U-shaped relationship was found in NSTE-ACS, indicating higher MACE risk for patients with BT above 36.8°C.
- The study suggests that BT could be a useful, low-cost indicator of inflammation and risk for recurrent ischemic events
Article Synopsis
- - The study focuses on vascular complications during transfemoral transcatheter aortic valve implantation (TAVI) and introduces a new risk score called the passage-puncture score to assess the best access site.
- - This score evaluates two factors: the feasibility of accessing the ilio-femoral arteries (passage score) and the suitability of the puncture site (puncture score) using pre-procedure CT scans.
- - Results showed that using the passage-puncture score helped identify safer access points and led to a low rate of minor vascular complications (6%) in the patients studied.
Article Synopsis
- Spontaneous coronary artery dissection (SCAD) is a significant cause of heart issues during and after pregnancy, marked by spontaneous tears in artery walls.
- Three cases of pregnancy-related SCAD were examined, all occurring post-partum, highlighting varying degrees of severity and complications among the patients.
- The study emphasizes the unpredictable nature of SCAD during pregnancy, with some patients experiencing life-threatening events while others had uncomplicated outcomes, showcasing the need for awareness and careful management.
Article Synopsis
- The study investigated changes in demographics, risk factors, clinical presentations, and outcomes of takotsubo syndrome (TTS) patients from 2004 to 2021, using data from the InterTAK registry.
- Over the years, the proportion of male patients increased, and there was a rise in cases of midventricular TTS as well as significant growth in the incidence of physical triggers.
- There was also a notable increase in 60-day mortality rates, although no significant change in 1-year mortality when excluding early deaths was observed, indicating a complex evolution of TTS and its management in recent years.
Article Synopsis
- Cardiogenic shock (CS) is a major cause of in-hospital deaths after acute coronary syndromes (ACS), with nearly 50% mortality, highlighting the need for personalized risk prediction.
- The ORBI score, designed to predict in-hospital CS in ACS patients undergoing percutaneous coronary intervention (PCI), has shown varying effectiveness between genders, necessitating improved risk assessment methods.
- A new score called SEX-SHOCK was developed, incorporating key health indicators, and demonstrated better predictive ability for both sexes compared to the ORBI score, thus advancing risk prediction strategies in ACS management.
Background And Aims: Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction and tubular damage. This study examined the predictive value of PENK for renal outcomes and mortality in patients with acute coronary syndrome (ACS).
Methods: Proenkephalin was measured in plasma in a prospective multicentre ACS cohort from Switzerland (n = 4787) and in validation cohorts from the UK (n = 1141), Czechia (n = 927), and Germany (n = 220).
A hypertensive response to exercise is a precursor leading to hypertension, which is a major risk factor for the development of heart failure and diastolic dysfunction. Herein, we aimed to assess blood pressure (BP) in patients with a hypertensive response to exercise and different degrees of diastolic dysfunction. Between January 2009 and December 2014, 373 patients with a hypertensive response to exercise (HRE) and echocardiographic data assessing diastolic function were enrolled at the University Hospital of Zurich.
View Article and Find Full Text PDFCardiogenic shock in takotsubo syndrome: etiology and treatment.
Cardiovasc Interv Ther
October 2024
Article Synopsis
- - Takotsubo syndrome (TTS) resembles acute coronary syndrome but is a separate condition that can sometimes lead to serious issues like cardiogenic shock.
- - Cardiogenic shock occurs in 1-20% of TTS cases and can be caused by multiple factors, such as pump failure and complications in heart function.
- - Accurate and early identification of the mechanism behind cardiogenic shock is crucial for providing the right treatment and improving patient outcomes in TTS cases.
Background: Left atrial appendage closure (LAAC) represents an alternative to oral anticoagulation for stroke prevention in patients with non-valvular atrial fibrillation (AF). While transoesophageal echocardiography is the current standard for guiding LAAC procedures, several centers have employed fluoroscopic guidance alone. However, data on long-term outcomes are lacking.
View Article and Find Full Text PDFTako-Tsubo syndrome (TTS) presents as transient ventricular dysfunction, yet its underlying pathophysiology remains enigmatic. The prognosis of patients presenting with TTS appears to be impaired as compared to the general population and is similar to patients with acute coronary syndromes. Recent investigations have predominantly focused on elucidating therapeutic strategies associated with improved outcomes, particularly among post-menopausal female patients.
View Article and Find Full Text PDFPoor oral health is an important concern for athletes, as it can affect both general health and athletic performance. The aim of this study is to investigate the effects of activity in chlorinated water on oral health in elite swimmers compared to non-swimming athletes. This cross-sectional study included 101 swimmers and 100 other athletes aged 13-26 years with a minimum training intensity of five hours per week (for at least the preceding two years).
View Article and Find Full Text PDFSafety and effectiveness of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: insights from the SPUM-ACS study.
Eur Heart J Cardiovasc Pharmacother
August 2024
Aims: Data on glycoprotein IIb/IIIa inhibitor (GPI) use in real-world acute coronary syndrome (ACS) patients following the introduction of potent P2Y12 inhibitors and newer-generation stents are scant. Here, we aimed to assess the utilization, effectiveness, and safety of GPI in a large prospective multicentre cohort of contemporary ACS patients.
Methods And Results: SPUM-ACS prospectively recruited patients presenting with ACS between 2009 and 2017.
Objective: We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-analysis using data from randomized controlled trials(RCTs).
Background: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardioprotective effects via multiple mechanisms that may also contribute to decrease arrhythmias risk.
Methods: We searched in databases (PubMed, Embase, Cochrane Library, and clinicaltrials.
Article Synopsis
- The study evaluates the long-term impact of IntraVascular UltraSound (IVUS) on outcomes for patients with Unprotected Left Main (ULM) coronary artery disease undergoing Percutaneous Coronary Intervention (PCI).
- Conducted across 13 European centers from 2002 to 2015, the research involved 627 patients, comparing those who received IVUS guidance to those who had traditional angiography.
- Results showed that patients in the IVUS group experienced significantly fewer major adverse cardiovascular events (MACEs), all-cause death, and the need for further revascularization, suggesting that IVUS-guided PCI improves long-term patient outcomes.
Background: Studies comparing long-term outcomes between non-vitamin K antagonist (VKA) oral anticoagulant agents (direct oral anticoagulant agents [DOACs]) and VKA anticoagulant agents after transcatheter aortic valve replacement (TAVR) are scarce, with conflicting results.
Objectives: The aim of this study was to examine the periprocedural, short-term, and long-term safety and effectiveness of DOACs vs VKAs in patients undergoing TAVR via femoral access with concomitant indications for oral anticoagulation.
Methods: Consecutive patients undergoing transfemoral TAVR in the prospective national SwissTAVI Registry between February 2011 and June 2021 were analyzed.
Article Synopsis
- Acute coronary syndromes (ACS) pose significant challenges globally, and they can lead to out-of-hospital cardiac arrest (OHCA), which has low survival rates despite medical advancements.
- This study developed the FACTOR score—a tool to predict in-hospital mortality for OHCA patients undergoing coronary angiography, based on admission variables like age, downtime, first detected rhythm, and epinephrine administration.
- The FACTOR score showed strong predictive accuracy, with an area under the curve of 0.823 in the derivation cohort and 0.828 in the validation cohort, potentially aiding healthcare providers in better managing resources and patient care.