Publications by authors named "Tempest Plott"
Article Synopsis
- Inflammasomes are important protein complexes in the immune system, and their malfunction is connected to various health issues, necessitating targeted treatments based on specific diseases.
- Researchers developed a sophisticated imaging assay for human immune cells, utilizing machine learning and cell biology techniques to analyze cellular responses related to inflammasome activity.
- This approach successfully identified over 100 distinct inflammasome inhibitors from a large library of compounds, showcasing the potential for machine learning to enhance the understanding of complex biological processes and aid in drug discovery.
Elucidation of familial relationships using hair shaft proteomics.
Forensic Sci Int Genet
September 2021
This study examines the potential of hair shaft proteomic analysis to delineate genetic relatedness. Proteomic profiling and amino acid sequence analysis provide information for quantitative and statistically-based analysis of individualization and sample similarity. Protein expression levels are a function of cell-specific transcriptional and translational programs.
View Article and Find Full Text PDFRecent reports highlight possible improvements in individual identification using proteomic information from human hair evidence. These reports have stimulated investigation of parameters that affect the utility of proteomic information. In addition to variables already studied relating to processing technique and anatomic origin of hair shafts, an important variable is hair ageing.
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