Soda intake influences phenotype, antioxidants and inflammatory status in high protein-fed wistar rats.

An increasing population of people, especially young adults who exercise, consume high protein diets along with carbonated drinks. While there are numerous studies on the effect of high protein diets, there is a need to understand how protein diets in combination with carbonated drinks impact physiology. In order to assess these effects on wistar rats' phenotype, antioxidants and inflammatory profiles, 64 wistar rats were divided into dietary groups of 8 male and 8 female animals each.

Effect of silymarin on blood coagulation profile and osmotic fragility in carbon tetrachloride induced hepatotoxicity in male Wistar rats.

Reports about the impact of Carbon tetrachloride (CCl) hepatotoxicity on coagulation profile have been inconsistent. Multiple investigators have however demonstrated the effectiveness of silymarin in the resolution of anomalies induced by CCl, although the effect of silymarin on the impact of CCl hepatotoxicity, especially coagulation profile and osmotic fragility have not been investigated. The liver, the primary site for the secretion of coagulation proteins, can become impaired in CCl hepatotoxicity, and silymarin reportedly increases hepatic protein synthesis as part of its hepatoprotective mechanism.

A high carbohydrate and soda diet influences metabolic variables in Wistar rats.

Aims: High carbohydrate diet and carbonated soda consumption have individually been associated with metabolic dysfunction, with links to glucose and insulin homeostasis, affecting metabolic variables associated with feeding, satiety and adiposity. Our objective is to determine the combined effect of a high carbohydrate and carbonated soda diet on metabolic variables in male and female Wistar rats.

Materials And Methods: Thirty-two female and male weanlings were equally divided into four dietary groups; Control, Soda, High Carbohydrate diet (HCD), and High Carbohydrate diet/Soda (HCD/Soda), and fed ad libitum for fourteen weeks.

Dietary reversal reverts diet-induced alterations in obstructed bladders of Wistar rats.

Objectives: The aim of this study was to investigate the effects of diet reversal to standard chow on diet-induced changes in structure and function of normal and obstructed bladders in male Wistar rats.

Methods: Eighty animals were equally divided into sham-surgery and bladder outlet obstruction (BOO) dietary groups and fed standard chow (control), high-carbohydrate, high-fat, and high-protein diets. BOO groups had surgically induced BOO, whereas sham surgery was performed on sham groups at the end of week 8.

Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats.

D-ribose-L-cysteine (DRLC) acts as a rate limiting substrate for the synthesis of glutathione (GSH). GSH deficiency has been linked to oxidative stress, hypertension and cardiovascular diseases. There are limited findings on the effects of DRLC in the physiologic state.

Methanol extracts of leaves alleviate stress in rats.

Objective: Stress is becoming an unavoidable threat in recent times, there has been increasing interest by researchers in the use of naturally occurring biologically active compounds with medicinal value to cure body ailments. The present work was carried out to investigate the effect of methanol extract of leaves on stress in Wistar rats (Rattus norvegicus).

Methods: A total of 35 male rats were used in this study.

Dietary intake of parents affects antioxidant activity and inflammatory status in F2 offspring.

Background: Dietary intake is implicated in the pathogenesis of non-communicable diseases, especially those affecting metabolism. Many non-communicable diseases are mediated by alterations in antioxidant activity and chronic inflammation with its resultant effects. Developmental programming causes offspring of parents with particular metabolic phenotypes to adopt predisposition to these phenotypes during development.

Multigenerational effects of dietary macronutrient intake on the metabolic phenotype of male Wistar rats.

Objectives: Gene-nutrient interactions are implicated in metabolic phenotypes like metabolic syndrome. The aim of this study was to examine the effects of diet-induced metabolic phenotypes in rats and investigate the effects of these phenotypes in three successive generations.

Methods: Three generations of rats were fed on different diets and mated.

Dietary macronutrient content affects inflammatory and fibrotic factors in normal and obstructed bladders.

Aims: To investigate the effects of diets on factors and markers of inflammation and fibrosis in unobstructed and obstructed bladders of male Wistar rats.

Materials And Methods: Partial BOO was surgically induced in twelve-week old rats after feeding on different diets for eight (8) weeks. Feeding continued for 4 weeks after surgery.