Association of Intimal Neovessels Noted by Optical Coherence Tomography with Cardiac Allograft Vasculopathy.

Background Cardiac allograft vasculopathy (CAV) is a leading cause of graft failure in cardiac transplant recipients. Progression of intimal thickening noted during routine surveillance intracoronary imaging is associated with the development of CAV. However, mechanisms of CAV development are poorly understood and targets for therapy modification remain elusive.

Cardiovascular disease: A global problem extending into the developing world.

This article reviews the current status of cardiovascular disease (CVD) on the international scale. Presently viewed as an epidemic that has migrated from westernized societies to developing countries, several important issues are elaborated upon. They include the basis for the increasing prevalence of CVD and the associated societal implications.

Prevalence and determinants of diabetic retinopathy and cataracts in West African type 2 diabetes patients.

Objective: To quantify the prevalence of, and risk factors for, diabetic retinopathy and cataracts in patients with type 2 diabetes, and their spouse controls, enrolled from 5 centers in 2 West African countries (Ghana and Nigeria).

Method: The analysis cohort was made up of 840 subjects with type 2 diabetes, and their 191 unaffected spouse controls, who were enrolled and examined in Lagos, Enugu, and Ibadan, in Nigeria, and in Accra and Kumasi, in Ghana. A diagnosis of diabetic retinopathy was made only where a participant had a minimum of one microaneurysm in any field, as well as exhibiting hemorrhages (dot, blot, or flame shaped), and maculopathy (with or without clinically significant edema).