Publications by authors named "Tekin B"

Article Synopsis
  • The study investigates porokeratosis localized to the penis and scrotum, analyzing data from patients diagnosed between 2000 and 2022.
  • Nine patients were included, with a median age of 51, and most had either penile or scrotal lesions, while one had extensive lesions affecting multiple areas.
  • The findings indicate that clinical diagnosis can be challenging and highlights the importance of histopathological examination, as follow-ups showed no recurrence or malignant transformation in patients after biopsy removal.
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Over the last few decades, the globe has faced severe challenges in isolating entire nations from social, economic, and environmental issues. However, rising pollution levels have become the most debatable agenda. To resolve this, the world has introduced a few green initiatives, i.

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The study aimed to evaluate the effectiveness of deep subgluteal block (DSGB) for pain relief after posterolateral-approached total hip replacement. The cadaver study and observational case series assessed the spread and outcomes of ultrasound-guided DSGB. Results showed low postoperative pain scores, minimal opioid requirements, and no complications related to DSGB.

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  • There is a lack of research on the effectiveness of hydroxychloroquine for treating lichen sclerosus, a condition that can lead to significant health issues if untreated.
  • The study analyzed 70 patients who received hydroxychloroquine, focusing on demographics, treatment responses, and outcomes, finding that a majority were female and itching was the most common symptom.
  • Results indicated a high response rate (84.6%) for anogenital lichen sclerosus, while extragenital lichen sclerosus had a lower rate (50%), though the study’s limitations suggest more extensive research is needed to confirm these findings.
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Paratesticular mesothelioma (malignant mesothelioma arising from the tunica vaginalis of the testis) represents a small proportion of mesothelial neoplasms, and cutaneous involvement by paratesticular mesothelioma is very rare. Cutaneous involvement can manifest as scrotal subcutaneous nodules from regional spread, distant metastasis, or direct extension through surgical scars. Mesothelioma has 3 histopathologic classifications that include epithelioid, biphasic, and sarcomatoid, which is rarely seen in paratesticular mesothelioma.

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Lichen planus (LP), an idiopathic, multifaceted chronic inflammatory disease with a heterogeneous clinical presentation, affects approximately 0.5-1% of the population. The various clinical manifestations of LP fall into three broad categories, namely cutaneous, appendageal, and mucosal, with further subclassification depending on the morphology and distribution patterns of individual lesions.

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Article Synopsis
  • - The study evaluated 121 patients with penile squamous cell carcinoma (pSCC) to explore how well different methods identify high-risk human papillomavirus (HPV) status and to analyze its prevalence and impact on patient outcomes.
  • - Results showed that 30.6% of patients were high-risk HPV-positive, with a high sensitivity (97.3%) of morphologic evaluation in predicting HPV status; progression was more common in high-risk HPV-negative patients.
  • - The findings suggest that HPV status and certain tumor characteristics can influence prognosis, with differentiation levels in HPV-negative tumors and basaloid morphology in HPV-positive cases playing a significant role in patient mortality.
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Discovery of effective systemic therapies for patients with advanced penile cancer has been slow to occur. Comprehensive genomic profiling from several studies shed light on the molecular oncogenesis of penile squamous cell carcinoma (PSCC) and differences between HPV-related and unrelated tumors. While these two subsets of PSCC appear distinct in their biology, there are not yet specific treatment strategies recommended on that basis.

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In a generic theory of gravity coupled to matter fields, the Smarr formula for black holes does not work properly if the contributions of the coupling constants defining the theory are not incorporated. However, these couplings, such as the cosmological constant or the dimensionful parameters that appear in the Lagrangian, are fixed parameters defining the theory, and they cannot be varied. Here, we present a robust method, applicable to any covariant Lagrangian, that upgrades the role of the couplings from being constants in the theory to being free parameters of the solutions.

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Article Synopsis
  • The study investigates the changes in staging criteria for pT2/pT3 penile squamous cell carcinoma (pSCC) and compares the current AJCC criteria with a proposed modified system based on histopathological variables.
  • A total of 48 cases were analyzed, showing no significant difference in disease-free survival (DFS) and progression-free survival (PFS) using AJCC criteria, but significant differences emerged using the modified criteria.
  • The proposed staging system may enhance prognostication for pT2/pT3 pSCC tumors, but further research is required to validate its effectiveness across different patient populations.
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Molecular investigations have led to increased therapeutic options for prostatic adenocarcinoma. A single case report of a :: gene fusion occurring in prostate cancer was previously reported. A review of the literature revealed that gene rearrangements are exceedingly rare molecular events in prostate cancer.

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Background: This in vivo study evaluated the effect of graphene oxide and graphite coatings, coupled with the micro-arc oxidation (MAO) surface roughening technique, known for their mechanical strength, chemical stability, and antibacterial properties. The main objective was to assess the degree of improvement in osseointegration of titanium implants resulting from these interventions.

Materials And Methods: In this study, 32 female rats were utilized and randomly allocated into four groups ( = 8 each): machined surface titanium implants (control), those roughened by the MAO method, those coated with graphene oxide-doped MAO, and those with a graphite-doped MAO coating.

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Primary prostatic adenocarcinoma (pPC) undergoes genomic evolution secondary to therapy-related selection pressures as it transitions to metastatic noncastrate (mNC-PC) and castrate resistant (mCR-PC) disease. Next generation sequencing results were evaluated for pPC (n = 97), locally advanced disease (involving urinary bladder/rectum, n = 12), mNC-PC (n = 21), and mCR-PC (n = 54). We identified enrichment of TP53 alterations in high-grade pPC, TP53/RB1 alterations in HGNE disease, and AR alterations in metastatic and castrate resistant disease.

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Introduction: The elderly population is unique and the prognostic scoring systems developed for the adult population need to be validated. We evaluated the predictive value of frequently used scoring systems on mortality in critically ill elderly sepsis patients.

Methodology: In this single-center, observational, prospective study, critically ill elderly sepsis patients were evaluated.

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Objective: The aim of this study was to evaluate the relationship between monocyte/high-density lipoprotein (HDL) ratio (MHR), an inflammatory marker, and diabetic nephropathy (DN), a microvascular complication of diabetes in diabetic patients and to investigate the effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on MHR.

Material And Methods: The study included 119 diabetic patients. Hemogram, glucose, HbA1c, urea, creatinine, albumin, HDL cholesterol, LDL cholesterol, triglycerides, total cholesterol, MHR, NLR (neutrophil-lymphocyte ratio), and CRP parameters were evaluated in blood parameters taken after 8-10 h of fasting before and 6 months after SGLT2 inhibitor use, and albumin, creatinine, and albumin/creatinine parameters were evaluated in urine samples.

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Article Synopsis
  • Cutaneous malignant mixed tumor (MMT) is a rare type of tumor originating from sweat glands, noted for having both malignant epithelial cells and a specific stroma, with only about 50 cases reported so far.
  • A 70-year-old woman had a mass on her eyebrow that was diagnosed as cutaneous MMT, which later spread to her lungs, confirmed through biopsy.
  • This case adds to the limited literature on cutaneous MMT with lung metastasis, highlighting the rarity of such occurrences and aiming to raise awareness among medical professionals.
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  • LPG is seen as a transitional energy source for BRICS-T countries, helping them navigate dependence on non-renewable fuels while considering renewable alternatives.
  • The study examines the connections between financial development, LPG consumption, economic growth, and their impacts on environmental degradation from 1993 to 2018, revealing mixed effects on ecological health and carbon emissions.
  • Results suggest that while LPG consumption can degrade the environment, financial institutions play a positive role in ecological well-being, highlighting the need for balanced policies that promote sustainable development.
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