Effects of Acceptance and Commitment Care in the Treatment of Aplastic Anemia Patients with Recombinant Human Thrombopoietin.

Background: This study was designed to determine the effects of acceptance and commitment care in the treatment of aplastic anemia (AA) patients with recombinant human thrombopoietin (rhTPO).

Methods: The clinical records of 100 AA patients treated at our hospital from March 2021 to March 2023 were analyzed in the retrospective study. All patients received immunosuppressants and rhTPO.

Plasma Interleukin-35 Levels Predict the Prognosis in Patients with HBV-Related Acute-on-Chronic Liver Failure.

This study aimed to investigate the impact of IL-35 on the prognosis of patients with HBV-ACLF. We recruited 69 patients with HBV-ACLF, 20 patients with chronic hepatitis B (CHB), 17 patients with liver cirrhosis (LC), and 20 healthy controls (HCs) from a regional infectious disease treatment center in China. Plasma levels of IL-35 at baseline were detected using ELISA.

Phylogeography and Evolutionary Dynamics of Tobacco Curly Shoot Virus.

Tobacco curly shoot virus (TbCSV), a begomovirus, causes significant economic losses in tobacco and tomato crops across East, Southeast, and South Asia. Despite its agricultural importance, the evolutionary dynamics and emergence process of TbCSV remain poorly understood. This study analyzed the phylodynamics of TbCSV by examining its nucleotide sequences of the coat protein (CP) gene collected between 2000 and 2022.

The Known and Unknown of Global Tick-Borne Viruses.

Ticks are crucial vectors for various pathogens associated with human and animal diseases, including viruses. Nevertheless, significant knowledge gaps prevail in our understanding of tick-borne viruses (TBVs). We here examined existing studies on TBVs, uncovering 870 documented virus species across 28 orders, 55 families, and 66 genera.

Binary Transformer Based on the Alignment and Correction of Distribution.

Transformer is a powerful model widely used in artificial intelligence applications. It contains complex structures and has extremely high computational requirements that are not suitable for embedded intelligent sensors with limited computational resources. The binary quantization technology takes up less memory space and has a faster calculation speed; however, it is seldom studied for the lightweight transformer.

Research on Downhole MTATBOT Positioning and Autonomous Driving Strategies Based on Odometer-Assisted Inertial Measurement.

In response to the current situation of backward automation levels, heavy labor intensities, and high accident rates in the underground coal mine auxiliary transportation system, the mining trackless auxiliary transportation robot (MTATBOT) is presented in this paper. The MTATBOT is specially designed for long-range, space-constrained, and explosion-proof underground coal mine environments. With an onboard perception and autopilot system, the MTATBOT can perform automated and unmanned subterranean material transportation.

A Bait-and-Hook Hydrogel for Net Tumor Cells to Enhance Chemotherapy and Mitigate Metastatic Dissemination.

: Lung cancer is an aggressive disease with rapid progression and a high rate of metastasis, leading to a significantly poor prognosis for many patients. While chemotherapy continues to serve as a cornerstone treatment for a large proportion of lung cancer patients, expanding preclinical and clinical evidence indicates that chemotherapy may promote tumor metastasis and cause side effects. : We develop an injectable bait-and-hook hydrogel (BH-gel) for targeted tumor cell eradication, which embedded doxorubicin liposomes as cytotoxic agents and CXCL12 as a chemoattractant to capture and kill tumor cells.

Investigation into the Reinforcement Modification of Natural Plant Fibers and the Sustainable Development of Thermoplastic Natural Plant Fiber Composites.

Natural plant fibers (NPFs) have emerged as a sustainable alternative in the manufacture of composites due to their renewability and low environmental impact. This has led to a significant increase in the use of natural plant fiber-reinforced polymers (NPFRPs) in a variety of industries. The diversity of NPF types brings a wide range of properties and functionalities to NPFRPs, which in turn highlights the urgent need to improve the properties of fiber materials in order to enhance their performance and suitability.

Effects of Exogenous Spermidine on Seed Germination and Physiological Metabolism of Rice Under NaCl Stress.

Salt stress is one of the principal abiotic stresses limiting agricultural production and seriously inhibiting seed germination rates. This study selected the salt-tolerant rice variety HD961 and the salt-sensitive rice variety 9311 as experimental materials to investigate the physiological and metabolic effects of exogenous Spd seed priming on rice seeds and seedlings under NaCl stress. The experiment involved treating rice seeds with 0.

Genome-Wide Identification and Expression Analysis of the G-Protein Gene Family in Barley Under Abiotic Stresses.

Heterotrimeric G-proteins are fundamental signal transducers highly conserved in plant species, which play crucial roles in regulating plant growth, development, and responses to abiotic stresses. Identification of G-protein members and their expression patterns in plants are essential for improving crop resilience against environmental stresses. Here, we identified eight heterotrimeric G-protein genes localized on four chromosomes within the barley genome by using comprehensive genome-wide analysis.

The Effect of Seasonal and Annual Variation on the Quality of Hua Rhizomes.

This study aims to reveal the interannual and seasonal variations in functional components in Hua. rhizomes and evaluate whether the variations significantly affect the quality of rhizomes as a traditional Chinese herbal medicine. The interannual and seasonal variations in total flavonoid content and total saponin content were analyzed.

Long-Term Variation Characteristics and Health Risks of Atmospheric Hg in the Largest City in Northwestern China.

In this study, gaseous element mercury (GEM) and gaseous oxidized mercury (GOM) in the atmosphere were continuously observed at a minute resolution from 1 April 2019 to 31 December 2020 in urban Xi'an, the largest central city in Northwestern China. The concentrations of GEM and GOM drastically fluctuated within the ranges of 0.022-297 ng/m and 0.

Contamination Characteristics of Antibiotic Resistance Genes in Multi-Vector Environment in Typical Regional Fattening House.

Antibiotic resistance genes (ARGs) are emerging as significant environmental contaminants, posing potential health risks worldwide. Intensive livestock farming, particularly swine production, is a primary contributor to the escalation of ARG pollution. In this study, we employed metagenomic sequencing and quantitative polymerase chain reaction to analyze the composition of microorganisms and ARGs across four vectors in a typical swine fattening facility: dung, soil, airborne particulate matter (PM), and fodder.

Hardness-Dependent Freshwater Quality Criteria for the Protection of Aquatic Organisms for Cadmium in China.

Cadmium poses a significant threat to freshwater aquatic organisms and ecosystems, making it essential to establish regional freshwater quality criteria (FWQC) in China to safeguard these organisms. The toxicity database for cadmium covered 249 acute toxicity data from 52 species (seven phyla and 27 families) and 62 chronic toxicity data from 21 species (four phyla and 12 families). During short-term exposure, displayed the most sensitivity to cadmium, whereas showed the most sensitivity in long-term exposure scenarios.

Oxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats.

Bisphenol A (BPA), extensively utilized in the manufacture of epoxy resins and polycarbonate plastics, is prevalent in the environment. Its exposure has been associated with an increased risk of hepatic lesions; however, the underlying mechanisms and the spectrum of its effects remain poorly understood. This study investigates the role of the Keap1-Nrf2 signaling pathway in regulating BPA-induced hepatotoxicity in vivo using a rat model.

Development of a PET Probe Targeting Bromodomain and Extra-Terminal Proteins for In Vitro and In Vivo Visualization.

Bromodomain and extra-terminal (BET) proteins are critical regulators of gene transcription, as they recognize acetylated lysine residues. The BD1 bromodomain of BRD4, a member of the BET family, has emerged as a promising therapeutic target for various diseases. This study aimed to develop and evaluate a novel C-11 labeled PET radiotracer, [C]YL10, for imaging the BD1 bromodomain of BRD4 in vivo.

An Enhanced Gas Sensor Data Classification Method Using Principal Component Analysis and Synthetic Minority Over-Sampling Technique Algorithms.

This study addresses the challenge of multi-dimensional and small gas sensor data classification using a gelatin-carbon black (CB-GE) composite film sensor, achieving 91.7% accuracy in differentiating gas types (ethanol, acetone, and air). Key techniques include Principal Component Analysis (PCA) for dimensionality reduction, the Synthetic Minority Over-sampling Technique (SMOTE) for data augmentation, and the Support Vector Machine (SVM) and K-Nearest Neighbor (KNN) algorithms for classification.

A Novel ANN-PSO Method for Optimizing a Small-Signal Equivalent Model of a Dual-Field-Plate GaN HEMT.

This study introduces a novel method that integrates artificial neural networks (ANNs) with the Particle Swarm Optimization (PSO) algorithm to enhance the efficiency and precision of parameter optimization for the small-signal equivalent model of dual-field-plate GaN HEMT devices. We initially train an ANN model to predict the S-parameters of the device, and subsequently utilize the PSO algorithm for parameter optimization. Comparative analysis with the NSGA2 and DE algorithms, based on convergence speed and accuracy, underscores the superiority of the PSO algorithm.

Electrostatic MEMS Two-Dimensional Scanning Micromirrors Integrated with Piezoresistive Sensors.

The MEMS scanning micromirror requires angle sensors to provide real-time angle feedback during operation, ensuring a stable and accurate deflection of the micromirror. This paper proposes a method for integrating piezoresistive sensors on the torsion axis of electrostatic MEMS micromirrors to detect the deflection angle. The design uses a multi-layer bonding process to realize a vertical comb-driven structure.

Parallel Farby-Perot Interferometers in an Etched Multicore Fiber for Vector Bending Measurements.

Vector bending sensors can be utilized to detect the bending curvature and direction, which is essential for various applications such as structural health monitoring, mechanical deformation measurement, and shape sensing. In this work, we demonstrate a temperature-insensitive vector bending sensor via parallel Farby-Perot interferometers (FPIs) fabricated by etching and splicing a multicore fiber (MCF). The parallel FPIs made in this simple and effective way exhibit significant interferometric visibility with a fringe contrast over 20 dB in the reflection spectra, which is 6 dB larger than the previous MCF-based FPIs.

Study on the Abrasive Blasting Mechanism of Solder Welded 304V Wire in Vascular Intervention.

The solder burrs on the 304V wire surface can easily scratch the vascular tissue during interventional treatment, resulting in complications such as medial tears, bleeding, dissection, and rupture. Abrasive blasting is often used to remove solder burr and obtain a smooth surface for the interventional device. This study conducted an abrasive blasting experiment to explore the effects of process parameters (air pressure, lift-off height, abrasive volume, and abrasive type) on processing time, surface roughness, and mechanical properties to reveal the material removal mechanism.

Selection of Representative Asphaltene Molecules in an Asphalt Molecular Model Based on Quantum Chemistry and Statistical Analysis.

Asphaltenes, as the most complex and strongly polar component among the four components of asphalt, have a significant impact on the macroscopic physicochemical properties of asphalt. Currently, the vast variety of molecular structures used to characterize asphaltenes increases the construction complexity of asphalt molecular models. To construct a more realistic asphalt molecular model and reduce the construction difficulty, this investigation obtains the molecular morphology, molecular polarity, and infrared spectrum indicators of 21 asphaltene molecules through quantum chemical calculations.

Detection of Total Aflatoxins in Herbal Medicines Based on Lateral Flow Assay with Contamination Ratio Model.

In this study, we developed a colloidal gold immunochromatographic strip (CGIS) method that used the matrix-matched calibration curves of contamination ratio models to quantitatively determine the total aflatoxin in five herbal medicines. This approach addresses issues related to false results and poor accuracy associated with conventional methods. The CGIS was analyzed using a Vertu touch reader, and the matrix-matched calibration was established based on the absorbance ratios of the T and C lines, as well as the logarithmic values of the total aflatoxin concentrations.

Preparation and Properties of Sulfur-Modified Alite Calcium Sulfoaluminate Cement.

Alite calcium sulfoaluminate (ACSA) cement is an innovative and environmentally friendly cement compared to ordinary Portland cement (OPC). The synthesis and hydration of ACSA clinkers doped with gradient sulfur were investigated. The clinker compositions and hydrated pastes were characterized by X-ray diffraction (XRD), isothermal calorimetry, mercury intrusion porosimetry (MIP), and scanning electron microscopy (SEM) to analyze its mineral contents, hydration products, heat release, pore structure, and microstructure.

Forming Control and Wear Behavior of M2 High-Speed Steel Produced by Direct Energy Deposition on Curved Surface.

Direct energy deposition (DED) technology shows promising applications in the production of roller die cutters. The optimization of process parameters, scanning strategies, and analyses of compressive properties and wear behavior are required prior to application. Therefore, this work investigated the influence of scanning strategy and overlap ratio on the microstructure, microhardness, compressive properties, and wear resistance of M2 high-speed steel (HSS) with DED on a 316 L cylindrical surface.