Publications by authors named "Tejas Mathai"

In radiology, Artificial Intelligence (AI) has significantly advanced report generation, but automatic evaluation of these AI-produced reports remains challenging. Current metrics, such as Conventional Natural Language Generation (NLG) and Clinical Efficacy (CE), often fall short in capturing the semantic intricacies of clinical contexts or overemphasize clinical details, undermining report clarity. To overcome these issues, our proposed method synergizes the expertise of professional radiologists with Large Language Models (LLMs), like GPT-3.

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Rationale And Objectives: Multi-parametric MRI (mpMRI) studies of the body are routinely acquired in clinical practice. However, a standardized naming convention for MRI protocols and series does not exist currently. Conflicts in the series descriptions present in the DICOM headers arise due to myriad MRI scanners from various manufacturers used for imaging, wide variations in imaging practices across institutions, and technologist preferences.

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Rationale And Objectives: In the United States, cirrhosis was the 12th leading cause of death in 2016. Despite end-stage cirrhosis being irreversible, earlier stages of hepatic fibrosis can be reversed via early diagnosis and intervention. The objective is to investigate the utility of a fully automated technique to measure liver surface nodularity (LSN) for staging hepatic fibrosis (stages F0-F4).

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Precise deformable image registration of multi-parametric MRI sequences is necessary for radiologists in order to identify abnormalities and diagnose diseases, such as prostate cancer and lymphoma. Despite recent advances in unsupervised learning-based registration, volumetric medical image registration that requires considering the variety of data distributions is still challenging. To address the problem of multi-parametric MRI sequence data registration, we propose an unsupervised domain-transported registration method, called OTMorph by employing neural optimal transport that learns an optimal transport plan to map different data distributions.

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Multi-parametric magnetic resonance imaging (mpMRI) exams have various series types acquired with different imaging protocols. The DICOM headers of these series often have incorrect information due to the sheer diversity of protocols and occasional technologist errors. To address this, we present a deep learning-based classification model to classify 8 different body mpMRI series types so that radiologists read the exams efficiently.

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Deformable image registration is one of the essential processes in analyzing medical images. In particular, when diagnosing abdominal diseases such as hepatic cancer and lymphoma, multi-domain images scanned from different modalities or different imaging protocols are often used. However, they are not aligned due to scanning times, patient breathing, movement, etc.

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Article Synopsis
  • Pheochromocytomas and Paragangliomas (PPGLs) are rare tumors with the ability to spread, and their management depends on specific genetic factors, making accurate localization via CT scans critical.
  • Radiologists face challenges due to the various sizes and appearances of PPGLs, leading to time-consuming manual annotations that are often inadequate.
  • An automated detection method using 2D and 3D neural network models has been proposed, achieving a 70% precision and 64.1% sensitivity in detecting PPGLs on CT scans, significantly improving upon traditional methods.
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  • The skeletal region is a common site for cancer spread from the breast and prostate, making detection of bone lesions crucial for patient monitoring.
  • The study presents an automated technique using CT scans to accurately identify various types of bone lesions (lytic, blastic, mixed) by training a model on weak 3D segmentation data.
  • The developed method achieved impressive results, detecting bone lesions with a precision of 96.7% and a recall of 47.3%, marking a novel approach to cancer lesion detection in CT imaging.
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Article Synopsis
  • AI has improved report generation in radiology but struggles with accurately evaluating these AI-produced reports due to inadequate assessment metrics.
  • The proposed solution combines radiologists' expertise with advanced AI models like GPT-3.5 and GPT-4, employing techniques like In-Context Instruction Learning and Chain of Thought reasoning to better align AI assessments with human standards.
  • Experimental results demonstrate that the new "Detailed GPT-4" model outperforms existing metrics, and the authors intend to share expert annotations to enhance future evaluations of AI-generated medical reports.
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Background: Segmentation of organs and structures in abdominal MRI is useful for many clinical applications, such as disease diagnosis and radiotherapy. Current approaches have focused on delineating a limited set of abdominal structures (13 types). To date, there is no publicly available abdominal MRI dataset with voxel-level annotations of multiple organs and structures.

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Multi-parametric MRI (mpMRI) studies are widely available in clinical practice for the diagnosis of various diseases. As the volume of mpMRI exams increases yearly, there are concomitant inaccuracies that exist within the DICOM header fields of these exams. This precludes the use of the header information for the arrangement of the different series as part of the radiologist's hanging protocol, and clinician oversight is needed for correction.

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Purpose: Body composition measurements from routine abdominal CT can yield personalized risk assessments for asymptomatic and diseased patients. In particular, attenuation and volume measures of muscle and fat are associated with important clinical outcomes, such as cardiovascular events, fractures, and death. This study evaluates the reliability of an Internal tool for the segmentation of muscle and fat (subcutaneous and visceral) as compared to the well-established public TotalSegmentator tool.

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Purpose: Lymph nodes (LNs) in the chest have a tendency to enlarge due to various pathologies, such as lung cancer or pneumonia. Clinicians routinely measure nodal size to monitor disease progression, confirm metastatic cancer, and assess treatment response. However, variations in their shapes and appearances make it cumbersome to identify LNs, which reside outside of most organs.

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Coronary artery calcification (CAC) is a strong and independent predictor of cardiovascular disease (CVD). However, manual assessment of CAC often requires radiological expertise, time, and invasive imaging techniques. The purpose of this multicenter study is to validate an automated cardiac plaque detection model using a 3D multiclass nnU-Net for gated and non-gated non-contrast chest CT volumes.

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The skeletal region is one of the common sites of metastatic spread of cancer in the breast and prostate. CT is routinely used to measure the size of lesions in the bones. However, they can be difficult to spot due to the wide variations in their sizes, shapes, and appearances.

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Multi-parametric MRI of the body is routinely acquired for the identification of abnormalities and diagnosis of diseases. However, a standard naming convention for the MRI protocols and associated sequences does not exist due to wide variations in imaging practice at institutions and myriad MRI scanners from various manufacturers being used for imaging. The intensity distributions of MRI sequences differ widely as a result, and there also exists information conflicts related to the sequence type in the DICOM headers.

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Article Synopsis
  • * CT scans are commonly used for locating these tumors, but their varied appearances make them hard to detect, leading to a slow manual identification process.
  • * To speed up detection, researchers developed an automated method using 3D imaging techniques, achieving a precision of 70% and sensitivity of 64.1% when tested on a dataset of 255 patients, indicating a successful way to streamline PPGL identification.
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Despite the reduction in turn-around times in radiology reporting with the use of speech recognition software, persistent communication errors can significantly impact the interpretation of radiology reports. Pre-filling a radiology report holds promise in mitigating reporting errors, and despite multiple efforts in literature to generate comprehensive medical reports, there lacks approaches that exploit the longitudinal nature of patient visit records in the MIMIC-CXR dataset. To address this gap, we propose to use longitudinal multi-modal data, i.

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Reliable localization of lymph nodes (LNs) in multi-parametric MRI (mpMRI) studies plays a major role in the assessment of lymphadenopathy and staging of metastatic disease. Radiologists routinely measure the nodal size in order to distinguish benign from malignant nodes, which require subsequent cancer staging. However, identification of lymph nodes is a cumbersome task due to their myriad appearances in mpMRI studies.

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Purpose: Body composition measurements from routine abdominal CT can yield personalized risk assessments for asymptomatic and diseased patients. In particular, attenuation and volume measures of muscle and fat are associated with important clinical outcomes, such as cardiovascular events, fractures, and death. This study evaluates the reliability of an Internal tool for the segmentation of muscle and fat (subcutaneous and visceral) as compared to the well-established public TotalSegmentator tool.

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Segmentation of multiple pelvic structures in MRI volumes is a prerequisite for many clinical applications, such as sarcopenia assessment, bone density measurement, and muscle-to-fat volume ratio estimation. While many CT-specific datasets and automated CT-based multi-structure pelvis segmentation methods exist, there are few MRI-specific multi-structure segmentation methods in literature. In this pilot work, we propose a lightweight and annotation-free pipeline to synthetically translate T2 MRI volumes of the pelvis to CT, and subsequently leverage an existing CT-only tool called TotalSegmentator to segment 8 pelvic structures in the generated CT volumes.

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Despite the reduction in turn-around times in radiology reporting with the use of speech recognition software, persistent communication errors can significantly impact the interpretation of radiology reports. Pre-filling a radiology report holds promise in mitigating reporting errors, and despite multiple efforts in literature to generate comprehensive medical reports, there lacks approaches that exploit the longitudinal nature of patient visit records in the MIMIC-CXR dataset. To address this gap, we propose to use longitudinal multi-modal data, i.

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Purpose: Reliable measurement of lymph nodes (LNs) in multi-parametric MRI (mpMRI) studies of the body plays a major role in the assessment of lymphadenopathy and staging of metastatic disease. Previous approaches do not adequately exploit the complementary sequences in mpMRI to universally detect and segment lymph nodes, and they have shown fairly limited performance.

Methods: We propose a computer-aided detection and segmentation pipeline to leverage the T2 fat-suppressed (T2FS) and diffusion-weighted imaging (DWI) series from a mpMRI study.

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Purpose: Identification of lymph nodes (LNs) that are suspicious for metastasis in T2 Magnetic Resonance Imaging (MRI) is critical for assessment of lymphadenopathy. Prior work on LN detection has been limited to specific anatomical regions of the body (pelvis, rectum). Therefore, an approach to universally detect both benign and metastatic nodes in T2 MRI studies of the body is highly desirable.

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