Publications by authors named "Teiba Obeidi"
Article Synopsis
- The study developed a new dexamethasone mixed micellar system (DEX-MM) using Soluplus and Pluronic F-127 to improve drug delivery to the eyes by creating a chitosan-coated version (DEX-CMM).
- The DEX-CMM exhibited high stability, uniform particle size, and effective prolonged drug release compared to a standard DEX suspension, enhancing drug absorption and permeation in ocular tissues.
- Safety tests indicated that DEX-CMM is non-irritating, supporting its potential as an effective method for delivering medication to the eyes.
Imipramine hydrochloride (IMP), a tricyclic antidepressant used for major depression, enuresis, and neuropathic pain, is limited by gastrointestinal complications, low oral bioavailability (44%), and complex dosing requirements. This study aimed to explore a novel non-invasive nasal delivery system using chitosan nanoparticles (Cs NPs) embedded in an in situ gel to address the limitations of oral IMP administration. Cs NPs loaded with IMP were synthesized via ionic gelation and assessed for precision in drug concentration using a validated HPLC method.
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