Publications by authors named "Teh-Yang Hwa"
Background: Modifications of lipid metabolism were closely associated with the manifestations and prognosis of coronavirus disease of 2019 (COVID-19). Pre-existing metabolic conditions exacerbated the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection while modulations of aberrant lipid metabolisms alleviated the manifestations. To elucidate the underlying mechanisms, an experimental platform that reproduces human respiratory physiology is required.
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- - Tuberculosis (TB), caused by Mycobacterium tuberculosis, leads to over 1 million deaths each year, with drug resistance complicating control efforts.
- - Researchers analyzed the genomes of multiple TB isolates from Taiwan, discovering new drug resistance mutations and demonstrating rapid genetic evolution in the pathogen.
- - A high-quality reference genome for the Beijing lineage of M. tuberculosis was created, which includes 212 additional genes not present in the standard reference strain, enhancing understanding of this predominant Asian lineage.
Article Synopsis
- Researchers sequenced the genome of the pineapple variety Ananas comosus var. bracteatus CB5, revealing insights into its genetic structure with 29,412 identified genes across 25 chromosomes.
- The study compared multiple pineapple genomes and revealed specific genetic traits related to fiber production, sugar accumulation, and fruit maturation, confirming varied domestication processes across cultivars.
- The findings indicate a blend of sexual and asexual reproduction in the domestication of clonally propagated crops, encouraging further investigation into these processes for other similar species.
Background: Neocallimastix patriciarum is one of the common anaerobic fungi in the digestive tracts of ruminants that can actively digest cellulosic materials, and its cellulases have great potential for hydrolyzing cellulosic feedstocks. Due to the difficulty in culture and lack of a genome database, it is not easy to gain a global understanding of the glycosyl hydrolases (GHs) produced by this anaerobic fungus.
Results: We have developed an efficient platform that uses a combination of transcriptomic and proteomic approaches to N.