Publications by authors named "Tegwinde R Compaore"
Purpose: The emergence of antibiotic resistance in pathogenic is a public health problem in tropical countries such as Burkina Faso. Antibiotic resistance could be identified using a variety of approaches. This study aimed to estimate the prevalence of pathogenic enterobacteria strains from three sources, as well as their antibiotic resistance profile to biotope and climatic season.
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- * The study involved 484 participants, primarily females, and found an overall dengue prevalence of 15.1%, with 2.9% of cases being asymptomatic. Subclinical and symptomatic cases made up 6.0% and 6.2%, respectively.
- * Determinants of dengue infection were analyzed, revealing that those who believed a virus transmitted dengue had significantly higher odds of being asymptomatic, indicating a connection between public perception and disease prevalence.
Article Synopsis
- Occult hepatitis B infection (OBI) is common worldwide, especially in regions like Africa, and can be spread through blood transfusions and organ transplants, with ties to liver cancer.
- A systematic review analyzed 83 studies to assess how common and genetically diverse OBI is across different African countries.
- Findings show OBI prevalence varies widely, peaking at 90.9% in hepatitis C patients and highlighting genotype D as the most prevalent strain in the continent.
Article Synopsis
- The study highlights that dengue fever is a growing health issue in Burkina Faso, especially in the Central Region, and it focuses on understanding its prevalence among adult febrile patients.
- Researchers conducted a thorough survey involving 637 patients, finding a dengue prevalence of 8.16%, with significant symptoms including vomiting and myalgia linked to specific dengue markers.
- Key findings indicate that living or spending time in the Arrondissement 4 area increases the likelihood of contracting dengue, while awareness of the disease appears to reduce its odds among participants.
Objectives: The objectives of this study were to determine the seroprevalence and risk factors of leptospirosis among slaughterhouse workers in Burkina Faso.
Methods: We performed a cross-sectional survey of slaughterhouse workers from Ouagadougou and Bobo Dioulasso between March and April 2021. Blood was collected by venipuncture and serum samples were tested using enzyme-linked immunosorbent assay and microscopic agglutination test.
Background: The aim of this study was to evaluate the performance of ten (10) SARS-CoV-2 serological rapid diagnostic tests in comparison with the WANTAI SARS-CoV-2 Ab ELISA test in a laboratory setting.
Materials And Methods: Ten (10) SARS-CoV-2 serological rapid diagnostic tests (RDTs) for SARS-CoV-2 IgG/IgM were evaluated with two (2) groups of plasma tested positive for one and negative for the other with the WANTAI SARS-CoV-2 Ab ELISA. The diagnostic performance of the SARS-CoV-2 serological RDTs and their agreement with the reference test were calculated with their 95% confidence intervals.
The human immunodeficiency virus (HIV) belongs to the Retroviridae family and remains a public health problem in sub-Saharan Africa. Recent reports from WHO have shown that 33 million people died from HIV infections. HIV is one of the most serious fatal human diseases of the 20th and 21st centuries.
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- - This study examined the prevalence and risk factors of HIV among people with disabilities (PWDs) in Burkina Faso, focusing on those with moderate to severe disabilities between the ages of 15 and 69.
- - Among the 973 PWDs evaluated, the overall HIV prevalence was found to be 4.6%, which is higher than that of the general population, with significant associations linked to age, type of impairment, financial status, and sexual behavior.
- - The findings highlight the urgent need for targeted HIV prevention strategies for PWDs, emphasizing education on safer sexual practices to reduce transmission rates.
Article Synopsis
- * Conducted in six regions of Mali, the research included 1,051 PWDs and found an overall HIV infection rate of 2.38%, with higher rates observed in women (3.31%) compared to men (0.78%).
- * Key risk factors identified include age, sex, type of disability, and experiences of sexual violence, highlighting the need for targeted HIV prevention strategies that include PWDs to meet the goal of ending the HIV/AIDS epidemic by 2030 in Mali.
Background: Breast cancer (BC) is the most commonly diagnosed cancer and the second leading cause of cancer-related deaths among women in Africa after cervical cancer. Even if the epidemiological data are now aligned with those relating to industrialized countries, the knowledge concerning breast cancer in Africa, particularly in Western Africa, still lack clinical data, medical treatments, and the evaluation of genetic and non-genetic factors implicated in the etiology of the disease. The early onset and the aggressiveness of diagnosed breast cancers in patients of African ancestry strongly suggest that the genetic risk factor may be a key component, but so far, very few studies on the impact of germ line mutations in breast cancer in Africa have been conducted, with negative consequences on prevention, awareness and patient management.
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- Hepatitis B virus genotype E is prevalent in West Africa, being the most common strain found in chronic hepatitis B patients.
- Factors linked to the development of hepatocellular carcinoma (HCC) include older age, male sex, and higher levels of HBV in the blood.
- Patients with HBV-E had lower hepatitis B e antigen (HBeAg) prevalence and viral load, but a higher rate of cirrhosis compared to those with another genotype (C/E), highlighting the need for tailored management strategies in the region.
Background: This study aimed to assess the pharmacokinetic profile of 150 mg rifabutin (RBT) taken every other day (every 48 h) versus 300 mg RBT taken every other day (E.O.D), both in combination with lopinavir/ritonavir (LPV/r), in adult patients with human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection.
View Article and Find Full Text PDFPharmacokinetics of plasma lopinavir and ritonavir in tuberculosis-HIV co-infected African adult patients also receiving rifabutin 150 or 300 mg three times per week.
Ann Clin Microbiol Antimicrob
January 2020
Background: To evaluate the pharmacokinetic of plasma lopinavir (LPV) and ritonavir (RTV) when co-administered with three times weekly (TPW) rifabutin (RBT) at a dose of either 150 or 300 mg in African tuberculosis (TB) and HIV co-infected adult patients.
Methods: This is a pharmacokinetic study conducted in Ouagadougou among patients treated with a standard dosage of LPV/RTV 400/100 mg twice daily and RBT 150 mg TPW (arm A = 9 patients) or rifabutin 300 mg TPW (arm B = 7 patients) based regimens. Patients were recruited from the Bogodogo and Kossodo district hospitals in Ouagadougou from May 2013 to December 2015.
Objectives A cluster of specialized KIR genes of specialized KIR genes has been shown to be associated with susceptibility or resistance to viral infections in humans. Therefore, this pilot study, this pilot investigation sought to determine the frequencies of KIR genes human immunodeficiency virus type 1( HIV-1) patients and establish their potential clinical involvement in disease progression and staging. Methods HIV-1 infected and healthy individuals were selected for this study.
View Article and Find Full Text PDFBackground: Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. In this study we aimed to determine firstly whether index variants were associated with the risk of developing EH in Burkina Faso and secondly to characterize cardiovascular risk markers.
View Article and Find Full Text PDFAPOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, expression in subjects' naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of mRNA than the controls carriers of the G minor allele.
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- The severity of liver disease and treatment response in hepatitis are influenced by the virus genotype, prompting a review of hepatitis virus genotypes in West Africa.
- The review identified 52 articles, revealing that hepatitis B virus (HBV) genotype E is the most prevalent (90.6%) in the region, showing low genetic diversity, while hepatitis C virus (HCV) genotypes 1 and 2 account for 96.4% of infections.
- The findings indicate a need for further research on the clinical impact of these genotypes and improved surveillance to prevent new, more dangerous strains from emerging.
Background/objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection.
Methods: Chronic HBV carriers and healthy patients were selected for this study.
Human immunodeficiency virus type 1 drug resistance in a subset of mothers and their infants receiving antiretroviral treatment in Ouagadougou, Burkina Faso.
J Public Health Afr
May 2018
Article Synopsis
- * A total of 50 mothers and 50 infants were examined, revealing that the most common HIV subtype was CRF02_AG, with significant resistance mutations such as M184V identified, which are linked to high-level resistance against certain medications.
- * The research indicated that some mothers and infants showed HIVDR, suggesting the need for a change in their treatment plans to enhance care and outcomes for these patients.
Background: The presence of HBV DNA in the liver (with detectable or undetectable HBV DNA in the serum) of individuals tested HBsAg negative by currently available assays is defined occult B Infection (OBI). It remains a potential transmission threat and risk to HBV chronic infection. The purpose of this study was to determine the OBI prevalence among HBsAg negative subjects and to characterize associated genotypes.
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- Antimalarial medications, like primaquine, can cause severe anemia in individuals with G-6-PD deficiency, which is prevalent in malaria-endemic regions like Burkina Faso.
- A systematic review analyzed existing studies to estimate the prevalence and genetic variants of G-6-PD deficiency in Burkina Faso, revealing an average prevalence of 16.6% in men and 6.5% in women.
- The review found that almost all cases (99.8%) of G-6-PD deficiency were due to the G-6-PD A- variant, and enzymatic deficiency was notably higher in males compared to females.
Epstein Barr Virus (EBV) and Human Herpes Virus 6 (HHV-6) are responsible for severe diseases, particularly in immunocompromised persons. There is limited data of the infection of these opportunistic viruses in Burkina Faso. The purpose of this study was to characterize EBV and HHV-6 subtypes and to assess their impact on CD4 T cell count, HIV-1 viral load and antiretroviral treatment in people living with HIV-1.
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- The study focused on gene polymorphisms related to homocysteine metabolism in malaria patients in Burkina Faso, using a sample of 42 diagnosed individuals.
- The analysis employed real-time PCR to detect four specific genotypes: MTHFR 677C>T, MTHFR 1298A>C, MTR 2756A>G, and MTRR 66A>G, revealing distinct genotype frequencies among the subjects.
- Significant correlations were found between certain genotypes and various health parameters, highlighting the association of the MTR A2756G alleles with malaria for the first time in this region.
Introduction: In most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors. The aim of this study is to determine the prevalence of these viruses in blood donors from the city of Ouagadougou, Burkina Faso.
Methods: The study included 198 blood donors of the Regional Blood Transfusion Centre of Ouagadougou.
Background: Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G) is a potent host defense factor, which interferes with HIV-1 and HBV. Our study had three objectives, to screen a population of HIV-1 infected and uninfected patients in Burkina Faso for HBV, to screen the population for APOBEC3G variants rs6001417, rs8177832, and rs35228531 previously described, and to analyze the effect of these three variants and their haplotypes on HIV-1/HBV co-infection in Burkina Faso.
Methods: HBV detection was performed on samples from HIV-1 infected and uninfected subjects using rapid detection tests and real-time PCR.