Human neutrophil alloantigen genotype frequencies in Thai blood donors.

Background: Antibodies to human neutrophil antigens (HNA) can cause transfusion reactions, as well as autoimmune and neonatal neutropenia. This study is the first to report the frequencies of human neutrophil antigen genotypes in the Thai population.

Materials And Methods: Three hundred unrelated, healthy Thai blood donors at the National Blood Centre, Thai Red Cross Society, Bangkok, Thailand were typed for HNA-1a, -1b, -1c, -3a, -3b and -4a using polymerase chain reaction with sequence-specific primers.