Indications for surgical treatment of intracerebral hemorrhage.

The authors report a series of 71 patients with intracerebral hemorrhage: 57 underwent surgery and 14, although suitable candidates for surgery, refused operation. The results are assessed in relation to the site of the hemorrhage, mode of onset, and interval between accident and operation.

L- and conventional forms of micrococci in the circulating blood of thrombocytopenic patients.

The multiplication of Gram-positive Cocci originating from L-forms carried by platelets of autoimmune thrombocytopenic patients, may be attributed to the primary platelet damage enhanced following interaction with bacteria.

Incorporation of 14C-thymidine in human platelets: possible relation with a diffuse infection of micrococci in the L form.

Following the results of previous researches suggesting that platelets might carry microbial forms, the incorporation of 14C-thymidine in suspensions of platelets from 500 normal human subjects has been taken under examination. The results have always yielded positive data even though with marked differences of a quantitative order from a case to another. The hypothesis that such an activity might be the consequence of a synthesis of DNA in the mitochondria had to be excluded.

Limitations of circulation time in the diagnosis of intracranial disease.

The mode circulation time was measured using intravenously injected technetium 99(m) and a collimation system devised to discriminate between the right and left sides of the head. The results in 21 normal men were used as a basis of assessing the findings in 205 patients, made up of five diagnostic groups (ischaemia, haematoma, subarachnoid haemorrhage, intracranial tumour, and head injury). The average mode circulation time in the affected hemisphere for the three groups with vascular disease was increased, but even in these groups half the patients had a mode circulation time within 1 SD of normal mean; similar results were found for asymmetry between the hemispheres.

Relationship between volume flow and velocity in the cerebral circulation.

The relationship between the velocity of the cerebral circulation and the cerebral blood flow was explored at varying levels of PaCO(2), systemic arterial pressure, intracranial pressure, and perfusion pressure, using radioisotope techniques in baboons. Only at low flow rates did velocity increase with flow, and then non-linearly; at high rates velocity increased progressively less. Changes in flow are reflected by changes in velocity in such restricted circumstances that mean circulation time is a very unreliable indication of cerebral blood flow.