Publications by authors named "Ted T Inaba"
Article Synopsis
- Norursodeoxycholic acid (norUDCA) has shown effective anti-cholestatic effects in an animal model, but in humans, it's eliminated mainly as norUDCA-23G through glucuronidation.
- The study focused on identifying which human UGT enzymes are responsible for this process and how genetic variations (single nucleotide polymorphisms) in UGT genes influence norUDCA-23G formation.
- UGT1A3 was found to be the key enzyme in this glucuronidation, with variations in its gene affecting how well norUDCA is processed, which could have implications for its use in cholestasis treatment.
Chenodeoxycholic acid (CDCA) is a liver-formed detergent and plays an important role in the control of cholesterol homeostasis. During cholestasis, toxic bile acids (BA) accumulate in hepatocytes causing damage and consequent impairment of their function. Glucuronidation, a conjugation reaction catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, is considered an important metabolic pathway for hepatic BA.
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