Publications by authors named "Ted S Kalbfleisch"
Article Synopsis
- Centromeres are defined by the histone variant CENP-A and, unlike most mammals, the horse chromosome 11 lacks satellite DNA.
- The CENP-A binding domain on horse chromosome 11 shifts within a 500 kb area between different individuals, leading to positional alleles that can change but are inherited in a Mendelian manner.
- Research shows that, during development across various tissues, the centromeric domain remains stable, indicating that the centromere sliding does not occur during this time.
Article Synopsis
- The study aimed to replicate successful biobanking methods used on Thoroughbred mares, this time on two adult stallions under the FAANG initiative, involving comprehensive examinations before humane euthanasia.
- After euthanasia, various biological samples, including sperm, skin biopsies, and fluids, were collected and preserved for further research and analysis.
- Mild health abnormalities were identified in both stallions, and genomic resources from the samples will enhance equine genomic research, particularly in understanding tissue-specific gene regulation based on sex.
Aberrant microRNA expression contributes to breast cancer progression and endocrine resistance. We reported that although tamoxifen stimulated miR-29b-1/a transcription in tamoxifen (TAM)-resistant breast cancer cells, ectopic expression of miR-29b-1/a did not drive TAM-resistance in MCF-7 breast cancer cells. However, miR-29b-1/a overexpression significantly repressed TAM-resistant LCC9 cell proliferation, suggesting that miR-29b-1/a is not mediating TAM resistance but acts as a tumor suppressor in TAM-resistant cells.
View Article and Find Full Text PDFOBJECTIVE To compare predictive values, extent of agreement, and gamithromycin susceptibility between bacterial culture results of nasopharyngeal swab (NPS) and bronchoalveolar lavage fluid (BALF) samples obtained from calves with bovine respiratory disease (BRD). ANIMALS 28 beef calves with clinical BRD. PROCEDURES Pooled bilateral NPS samples and BALF samples were obtained for bacterial culture from calves immediately before and at various times during the 5 days after gamithromycin (6 mg/kg, SC, once) administration.
View Article and Find Full Text PDFAcquired tamoxifen (TAM) resistance is a significant clinical problem in treating patients with estrogen receptor α (ERα)+ breast cancer. We reported that ERα increases nuclear respiratory factor-1 (NRF-1), which regulates nuclear-encoded mitochondrial gene transcription, in MCF-7 breast cancer cells and NRF-1 knockdown stimulates apoptosis. Whether NRF-1 and target gene expression is altered in endocrine resistant breast cancer cells is unknown.
View Article and Find Full Text PDF