Publications by authors named "Ted H-T Chang"
Article Synopsis
- * In adult mice, Tbx3 is primarily expressed in hormone receptor-positive luminal cells, crucial for mammary epithelial identity, and its absence affects the formation of these cells.
- * This study highlights the cell type-specific targets of Tbx3, revealing its vital role in generating hormone-sensing cells in the mammary gland.
Breast Cancer Res
January 2014
Article Synopsis
- Parity-identified mammary epithelial cells (PI-MECs) survive a process called involution and may play a key role in mammary tumors related to HER2/neu, acting as either lobule-restricted progenitors or multipotent stem/progenitor cells.
- The study utilized techniques like immunohistochemistry and flow cytometry to analyze PI-MECs in intact mammary glands, confirming their identity and lineage potential during pregnancy and involution.
- Results showed that after involution, PI-MECs are primarily located in the luminal layer and mainly contribute to luminal ER-negative cells, while a significant portion of alveolar progenitors,
