Publications by authors named "Tecla Malizia"
Objectives: The administration of antibacterial agents should be optimized on the basis of their distribution to enhance drug exposure and obtain bacterial eradication. This study examines the pharmacokinetics of azithromycin in plasma, lung tissue and bronchial washing in patients after oral administration of 500 mg versus 1000 mg once daily for 3 days.
Patients And Methods: Samples of plasma, lung tissue and bronchial washing were obtained from a cohort of 48 patients during open-chest surgery for lung resection up to 204 h after the last drug dose, and assayed for antibiotic concentrations.
Article Synopsis
- The study involved 56 pediatric patients receiving azithromycin at doses of 10 or 20 mg per kg for 3 days.
- The researchers measured azithromycin levels in both plasma and tonsils up to 8.5 days after treatment.
- The findings indicated that the higher 20-mg/kg dose led to better distribution of the drug in the tonsils, which may improve treatment effectiveness for upper respiratory infections.