Introduction: Brucellosis, the most common zoonosis globally, is considered a major public health problem.
Objective: A retrospective study was carried out over 21 years (1998-2018) to determine the epidemiological features of human brucellosis in the province of El-Oued (south-eastern Algeria).
Results: 1,832 confirmed cases of human brucellosis were reported during the study period, with an average incidence rate of around 12.