Molecular regulation of virulence in Legionella pneumophila.

Legionella pneumophila is a gram-negative bacteria found in natural and anthropogenic aquatic environments such as evaporative cooling towers, where it reproduces as an intracellular parasite of cohabiting protozoa. If L. pneumophila is aerosolized and inhaled by a susceptible person, bacteria may colonize their alveolar macrophages causing the opportunistic pneumonia Legionnaires' disease.

Autorepressor PsrA is required for optimal Legionella pneumophila growth in Acanthamoeba castellanii protozoa.

Legionella pneumophila possesses a unique intracellular lifecycle featuring distinct morphological stages that include replicative forms and transmissive cyst forms. Expression of genes associated with virulence traits and cyst morphogenesis is concomitant, and governed by a complex stringent response based-regulatory network and the stationary phase sigma factor RpoS. In Pseudomonas spp.

Development of a Fluorescent Tool for Studying Intracellular Infection.

Legionnaires' disease incidence is on the rise, with the majority of cases attributed to the intracellular pathogen, Nominally a parasite of protozoa, can also infect alveolar macrophages when bacteria-laden aerosols enter the lungs of immunocompromised individuals. pathogenesis has been well characterized; however, little is known about the >25 different spp. that can cause disease in humans.

Complete Genome Sequences of Two Environmental Isolates Obtained from Potable Water Sourced in a First Nation Community.

Here, we report the complete genome sequences of two distinct isolates of that were obtained from potable water sourced from cistern-bearing homes within a First Nation community in Manitoba, Canada.