Publications by authors named "Te Yin"
Article Synopsis
- Bacterial outer membrane vesicles (OMV) show promise as protein vaccine carriers due to their self-adjuvant properties and biocompatibility, but their use is limited by immunotoxicity.
- Researchers developed an enhanced version, EMV, by gene-editing to remove harmful proteins, resulting in reduced inflammatory responses in mouse models.
- EMV efficiently displays protein antigens and enhances dendritic cell uptake, leading to strong immune responses, making them a suitable candidate for vaccine delivery against various infectious diseases.
Inflammation-oriented montmorillonite adjuvant enhanced oral delivery of anti-TNF-α nanobody against inflammatory bowel disease.
Proc Natl Acad Sci U S A
September 2024
Article Synopsis
- Oral delivery of proteins (like medicines) is tricky because strong stomach acids and enzymes can break them down.
- Scientists suggest using a special clay called montmorillonite (MMT) to help deliver these proteins safely to the gut without breaking them.
- This MMT can help keep the proteins active and also improve gut health by promoting helpful bacteria that boost the immune system.
Article Synopsis
- Oncolytic bacteria, particularly attenuated Salmonella typhimurium (VNP20009), show promise as a targeted therapy for tumors, but balancing effectiveness and safety remains a challenge.
- A new delivery system enhances the tumor-targeting capability of VNP20009 by loading it into neutrophils, improving its therapeutic effects in melanoma lung metastasis.
- The addition of a PD1 nanobody to this system boosts immune responses by activating dendritic cell maturation and enhancing the activation of CD4 and CD8 T-cells, leading to improved overall treatment efficacy.