Publications by authors named "Tayyaba Jiwani"
Cerebellar granule cell (GC) development relies on precise regulation of sonic hedgehog (Shh)-Gli signalling activity, failure of which is associated with motor disorders and medulloblastoma. Mutations in the pathway regulator suppressor of fused (Sufu), which modulates Gli activators and repressors, are linked to cerebellar dysfunction and tumourigenesis. The mechanism by which Sufu calibrates Shh signalling in GCs is unknown.
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- SuFu deficiency in the murine mid-hindbrain disrupts cerebellar development, leading to dysplastic features and delayed differentiation of neuronal precursors.
- In vitro studies reveal that these SuFu-deficient precursors have an increased ratio of radial glial cells compared to neurons, but their differentiation can be rescued by the expression of the GLI3R transcriptional repressor.
- The study identifies Fgf15 up-regulation in SuFu-deficient cerebella, with evidence that this signaling pathway can inhibit neuronal differentiation, suggesting that SuFu, GLI3R, and Fgf15 play critical roles in neuronal development in the cerebellum.