Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?

Objective: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS).

Subjects And Methods: This study included 203 women (99 women with PCOS and 104 controls). The genotyping was performed by PCR-RFLP.