Publications by authors named "Taylor Won"
Article Synopsis
- Accurate genome assemblies are crucial for biological research, but they often have errors due to the technologies used, necessitating polishing steps to correct these mistakes.
- The new model, DeepPolisher, utilizes Pacbio HiFi read alignments and a method called PHARAOH to improve sequences by accurately addressing haplotypes and correcting errors in areas previously thought to be homozygous.
- Testing DeepPolisher on 180 assemblies from the Human Pangenome Reference Consortium showed a significant reduction in assembly errors, achieving an average improvement of 54% in error reduction with a predicted Quality Value increase of 3.4.
The antigenic and genomic stability of paramyxoviruses remains a mystery. Here, we evaluate the genetic plasticity of Sendai virus (SeV) and mumps virus (MuV), sialic acid-using paramyxoviruses that infect mammals from two Paramyxoviridae subfamilies (Orthoparamyxovirinae and Rubulavirinae). We performed saturating whole-genome transposon insertional mutagenesis, and identified important commonalities: disordered regions in the N and P genes near the 3' genomic end were more tolerant to insertional disruptions; but the envelope glycoproteins were not, highlighting structural constraints that contribute to the restricted antigenic drift in paramyxoviruses.
View Article and Find Full Text PDF