Publications by authors named "Taylor Pindi Sala"
Article Synopsis
- Long-term adherence to chronic disease treatments is challenging, with only about 50% adherence in developed nations, prompting a need for effective management strategies.
- The study evaluated how satisfaction with the Flexig mHealth application influenced adherence to subcutaneous immunoglobulin therapy among French patients with chronic dysimmune diseases over two years.
- Results showed a high adherence rate of 99.7% linked to good user satisfaction with Flexig, indicating that digital tools can significantly enhance treatment compliance for patients.
The most common peripheral nervous system manifestations in Sjogren's syndrome are small fiber sensory neuropathies (SFPN) and axonal sensorimotor polyneuropathies. Currently, treatment in small fiber neuropathy is mainly symptomatic and based on anti-depressors and anti-epileptics. The benefit of treatment with polyvalent immunoglobulins for SFPN has been reported in small series of patients, although transient in several cases.
View Article and Find Full Text PDFAzathioprine (AZA), an oral immunosuppressant, is safe during pregnancy. Some reports suggested different impairments in the offspring of mothers with autoimmune diseases (AI) exposed in utero to AZA. These observations are available from retrospective studies or case reports.
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- Immunoglobulins are used as secondary or tertiary treatments for dermatomyositis (DM) and polymyositis (PM) when corticosteroids and immunosuppressants fail, typically administered intravenously once a month or subcutaneously at home a few times a week.
- A study involving seven patients (six with PM and one with DM) explored their experiences with both intravenous immunoglobulins (IVIg) and subcutaneous immunoglobulins (SCIg), revealing varied clinical profiles and significant improvements in symptoms after treatment.
- Patients found SCIg to be more convenient and less disruptive to daily life compared to IVIg, allowing them to regain autonomy and control over their treatment while still being effective and well tolerated.
Immunoglobulin (Ig) therapy is used to treat a wide range of immunodeficiencies and autoimmune diseases; While, its clinical benefit has been demonstrated in several studies, Ig therapy is associated with a risk of systemic adverse effects. As such, Onset of renal impairment, including acute renal failure, osmotic nephrosis and renal insufficiency, after immunoglobulin administration is rare, but is one of the most significant concerns related to intravenous Ig use at immunomodulatory doses. However, only few studies have investigated the safety of subcutaneous Ig (SCIg) in relation to these rare conditions.
View Article and Find Full Text PDFWe reviewed the efficacy of SCIg administration in terms of muscle strength maintenance and patient satisfaction comparing with IVIg in the treatment of auto-immune neuromuscular diseases. A systematic review was conducted, and identified studies from databases (PUBMED, EMBASE, EBSCO, Web of Science and Google Scholar) which were analyzed. The methodological quality of the selected publications was evaluated using the Newcastle-Ottawa Scale.
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- - Patients with primary immunodeficiency (PID) often receive immunoglobulin replacement therapy (IgRT) via methods like subcutaneous infusions using either an automated pump (P) or manual syringe push (RP), with P being less frequent but longer in duration compared to the more frequent but quicker RP infusions.
- - A study involving interviews with PID patients revealed that while RP is slightly more cost-effective and has similar efficacy to P, many patients preferred P due to better integration into their daily routine and less frequent reminders of their disease.
- - The focus group indicated that the complexity of living with PID influences their delivery method preference, as patients found RP cumbersome and not necessarily time-saving, suggesting that healthcare providers should explore these personal experiences further
Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis.
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