The Hunga Tonga-Hunga Ha'apai volcanic barometric pressure pulse and meteotsunami travel recorded in several Antarctic stations.

The Hunga Tonga-Hunga/Hunga-Ha'apai eruption on January 15, 2022 sent off a plume of ash material up to the stratosphere and triggered a meteotsunami and barometric pressure pulse that rippled through the atmosphere and oceans all around the world. The nature of the volcanic event and its global impacts on the oceans, atmosphere, lithosphere and the cryosphere are a matter of debate. Here we present a first overview of the time travel of the sound atmospheric pressure wave through the Antarctic continent based on in situ measurements, which represented a unique event observed through the polar ice sheet during the instrumental meteorological era.

Level One Trauma Center Proliferation May Worsen Patient Outcomes.

Background: From 2013 to 2020, Arizona state trauma system expanded from seven to thirteen level 1 trauma centers (L1TCs). This study utilized the state trauma registry to analyze the effect of L1TC proliferation on patient outcomes.

Methods: Adult patients age≥15 in the state trauma registry from 2007-2020 were queried for demographic, injury, and outcome variables.

Impact of lower level trauma center proliferation on patient outcomes.

Background: In attempt to increase trauma system coverage, our state added 21 level 3 (L3TC) and level 4 trauma centers (L4TC) to the existing 7 level 1 trauma centers from 2008 to 2012. This study examined the impact of adding these lower-level trauma centers (LLTC) on patient outcomes.

Methods: Patients in the state trauma registry age ≥ 15 from 2007 to 2012 were queried for demographic, injury, and outcome variables.

The Effect of Patient Positioning on Ureteral Efflux During Intraoperative Cystoscopy: A Randomized Controlled Trial.

Study Objective: To identify the relationship between patient position during surgery and time to confirmation of ureteral patency on cystoscopy.

Design: Randomized controlled trial.

Setting: Academic tertiary care medical center.

The surgical gender gap: the impact of surgeon gender in medicine and gynecologic surgery.

Purpose Of Review: The purpose of this review is to summarize the current literature evaluating the effect of surgeon gender on patient outcomes and satisfaction, and the impact of gender bias on female surgeons.

Recent Findings: The proportion of female physicians has increased in recent years, especially in Obstetrics and Gynecology. Recent literature assessing this impact supports equivalent or superior medical and surgical outcomes for women surgeons and physicians.

Management of nausea and vomiting from poly(ADP-ribose) polymerase inhibitor therapy for advanced ovarian cancer.

Poly(ADP-ribose) polymerase (PARP) inhibitors have rapidly emerged as a new class of daily oral chemotherapeutic agents that have the potential to dramatically alter the way in which primary peritoneal, fallopian tube and ovarian cancers are treated. However, the management of nausea and vomiting, the most common toxicities incurred by these agents, remains poorly understood. The purpose of this review is to provide an overview of current guidelines, antiemetic agents and management steps for patients experiencing nausea and vomiting associated with the use of PARP inhibitors.

Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells.

Glycolipids were depleted from the membranes of human A431 cells using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), an inhibitor of glucosylceramide synthetase. After 6 days of culture in the presence of 5 microM D-threo-PDMP, glycolipid content was reduced to approximately 5% of control levels. By contrast, synthesis per cell of phosphatidylcholine, sphingomyelin, triglycerides, and glycoprotein was relatively unchanged in PDMP-treated cells.

Inhibition of lymphocyte transformation by a factor from Pseudomonas aeruginosa.

Extracts of the bacteria Pseudomonas aeruginosa contain a specific inhibitor of lymphocyte transformation. Considerable purification of this inhibitor was possible by a) smashing the bacteria with glass beads, and b) extracting the soluble components with phosphate buffered saline, c) partial purification with ethanol fractionation, d) ion-exchange column chromatography (DEAE-Sephacel) and e) final purification by elution from Ultrogel. The inhibitor was active at a concentration of approximately 10 ng/ml in inhibiting two-way mixed lymphocyte culture of histoincompatible murine splenic lymphocytes in vitro.