Novel immunomodulatory properties of adenosine analogs promote their antiviral activity against SARS-CoV-2.

The COVID-19 pandemic reminded us of the urgent need for new antivirals to control emerging infectious diseases and potential future pandemics. Immunotherapy has revolutionized oncology and could complement the use of antivirals, but its application to infectious diseases remains largely unexplored. Nucleoside analogs are a class of agents widely used as antiviral and anti-neoplastic drugs.

Human erythroid progenitors express antigen presentation machinery.

Early-life immune exposures can profoundly impact lifelong health. However, functional mechanisms underlying fetal immune development remain incomplete. Erythrocytes are not typically considered active immune mediators, primarily because erythroid precursors discard their organelles as they mature, thus losing the ability to alter gene expression in response to stimuli.

Coliphages of the human urinary microbiota.

Due to its frequent association with urinary tract infections (UTIs), Escherichia coli is the best characterized constituent of the urinary microbiota (urobiome). However, uropathogenic E. coli is just one member of the urobiome.

When Plaquing Is Not Possible: Computational Methods for Detecting Induced Phages.

High-throughput sequencing of microbial communities has uncovered a large, diverse population of phages. Frequently, phages found are integrated into their bacterial host genome. Distinguishing between phages in their integrated (lysogenic) and unintegrated (lytic) stage can provide insight into how phages shape bacterial communities.

Examination of Prophages Circulating in Egypt.

infections are of growing concern given the increased incidence of antibiotic resistant strains. Egypt, like several other countries, has seen alarming increases in methicillin-resistant (MRSA) infections. This species can rapidly acquire genes associated with resistance, as well as virulence factors, through mobile genetic elements, including phages.

Mimicking prophage induction in the body: induction in the lab with pH gradients.

The majority of bacteria within the human body are lysogens, often harboring multiple bacteriophage sequences (prophages) within their genomes. While several different types of environmental stresses can trigger or induce prophages to enter into the lytic cycle, they have yet to be fully explored and understood in the human microbiota. In the laboratory, the most common induction method is the DNA damaging chemical Mitomycin C.

Introducing Lu-1, a Novel Lactobacillus jensenii Phage Abundant in the Urogenital Tract.

Bacteriophages (phages) play a key role in shaping microbial communities, including those of the human body. Phages are abundant members of the urogenital tract, most often persisting through the lysogenic life cycle as prophages integrated within the genomes of their bacterial hosts. While numerous studies of the urogenital microbiota have focused on the most abundant bacterial member of this niche-Lactobacillus species-very little is known about Lactobacillus phages.

Draft Genome Sequence of Escherichia coli UMB9246, Isolated from the Bladder of a Woman with Recurrent Urinary Tract Infection.

is a Gram-negative, motile, rod-shaped bacterium that causes the majority of uncomplicated urinary tract infections (UTIs). Here, we report the draft genome of strain UMB9246, an isolate from a woman with recurrent UTI.

Draft Genome Sequence of Staphylococcus epidermidis UMB8493, Isolated from the Female Urinary Tract.

is a native member of the human microbiota. Here, we report the draft genome sequence of UMB8493, an isolate from a catheterized urine sample from a female with overactive bladder symptoms. The 2.

Draft Genome Sequence of Escherichia coli UMB1353, Isolated from the Female Urinary Tract.

Here, we present the draft genome sequence of UMB1353, isolated from a patient with a urinary tract infection. The sequence of this antibiotic-resistant strain contains one intact P2-like phage.

Draft Genome Sequence of Streptococcus anginosus UMB0839, Isolated from the Female Urinary Tract.

Here, we present the draft genome sequence of UMB0839, isolated from the female urinary tract. The total size of the genome is 2,104,786 bp assembled into 42 contigs with a GC content of 38.8% and 284× genome coverage.

Draft Genome Sequence of Lactobacillus crispatus UMB1163, Isolated from the Female Urinary Tract.

is a Gram-positive bacterium shown to protect against urinary and vaginal infections. Here, we report the draft genome sequence of UMB1163, isolated from the female urinary tract.

Draft Genome Sequence of Actinomyces neuii UMB1295, Isolated from the Female Urinary Tract.

is an opportunistic pathogen. Within the urogenital tract, it has been associated with bacterial vaginosis and overactive bladder symptoms. Here, we investigate a draft genome sequence of UMB1295, which was isolated from a catheterized urine sample from a woman with a urinary tract infection.

Draft Genome Sequence of Enterococcus faecalis UMB1309, Isolated from Catheterized Urine.

A strain of was isolated from catheterized urine. Here, we present the draft genome sequence of this isolate, UMB1309. Analysis of the genome revealed multiple genes coding for virulence factors, as well as genes associated with antibiotic resistance.

Draft Genome Sequence of Enterococcus faecalis UMB7780, Isolated from the Female Urinary Tract.

Here, we present the draft genome sequence of UMB7780, isolated from the female urinary tract. The genome size is 3,005,901 bp, with a GC content of 37.36%, genome coverage of 179×, and an score of 169,627 bp.

Draft Genome Sequence of Corynebacterium aurimucosum UMB7769, Isolated from the Female Urinary Tract.

Here, we present the draft genome sequence of UMB7769, isolated from the female urinary tract. The size of the genome is 2,731,818 bp, assembled in 50 contigs, with an observed GC content of 60.9% and an score of 129,518 bp.

Draft Genome Sequence of Streptococcus anginosus UMB7768, Isolated from a Woman with Recurrent UTI Symptoms.

recently was implicated as a pathogen involved in urinary tract infections. A strain of was isolated from the female urogenital tract. Here, we present the draft genome sequence of strain UMB7768.

Draft Genome Sequence of Lactobacillus jensenii UMB0836, Isolated from the Female Bladder.

is a frequent member of both the vaginal and urinary microbiota. Here, we present the draft genome sequence for UMB0836, isolated from catheterized urine obtained from a pregnant female. The genome is 1,648,234 bp long, assembled in 40 contigs.

Draft Genome Sequence of Lactobacillus mulieris UMB7784, Isolated from the Female Urinary Tract.

We sequenced the genome of UMB7784, isolated from the urinary tract. With a genome size of 1,695,489 bp and a GC content of 34.2%, the draft genome sequence presented here expands our understanding of lactobacilli in the female bladder.

Draft Genome Sequence of Proteus mirabilis Strain UMB0038, Isolated from the Female Bladder.

is a Gram-negative motile and rod-shaped bacterium that is a common pathogen of the urinary tract. Here, we report the draft genome sequence of UMB0038, which was isolated from a woman without lower urinary tract symptoms.

Draft Genome Sequence of Streptococcus agalactiae UMB7782, Isolated from the Female Urinary Tract.

is a Gram-positive bacterium common to the human gut and vaginal microbiota. Here, we report the 2.1-Mbp draft genome sequence of UMB7782, isolated from a urine sample from a woman with a recurrent urinary tract infection.

Draft Genome Sequence of Staphylococcus epidermidis UMB7765, Isolated from the Urobiome of a Woman with Recurrent Urinary Tract Infection.

is a Gram-positive bacterium that is resistant to many antibiotics. Here, we present the 2.5-Mb draft genome of UMB7765, isolated from a voided urine sample from a female with recurrent urinary tract infections.

Draft Genome Sequence of Streptococcus anginosus UMB1296, Isolated from the Female Urinary Tract.

We present the draft genome sequence of a strain isolated from the female urinary tract. The UMB1296 draft genome has a size of 1,924,009 bp assembled into 35 contigs with a GC content of 38.69%.

Draft Genome Sequence of UMB9245, Isolated from the Female Bladder.

is an anaerobic bacterium found in the urogenital tract that is known to prevent common vaginal infections. Recently, it was divided into two species, and Here, we report the draft genome sequence of UMB9245, with a genome length of 1,723,383 bp assembled into 52 contigs.