The Use of Consumer Wearable Physical Activity Monitors in Clinical Populations with Functional Limitations.

Functionally limiting health conditions have a high rate of prevalence worldwide and incur a significant amount of economic burden. Physical activity (PA) can prevent the onset of these conditions and alleviate economic burden by reducing symptoms, but a large portion of these individuals do not engage in health enhancing PA. Consumer wearable physical activity monitors (WPAM) are tools that have become increasingly popular within the past few years and could provide a means to improve PA levels for individuals with health conditions that cause functional limitations.

MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.

Innate immune cells are integral to the pathogenesis of several diseases of the central nervous system (CNS), including multiple sclerosis (MS). Dendritic cells (DCs) are potent CD11c antigen-presenting cells that are critical regulators of adaptive immune responses, particularly in autoimmune diseases such as MS. The regulation of DC function in both the periphery and CNS compartment has not been fully elucidated.