Publications by authors named "Taylor L Yu"
Nucleic Acids Res
December 2017
Article Synopsis
- Alternative end-joining (alt-EJ) repair can lead to harmful genetic changes, such as deletions and translocations, by using microhomologous sequences to link broken DNA ends.
- A model called synthesis-dependent microhomology-mediated end joining (SD-MMEJ) suggests that new microhomologies can be created through limited DNA synthesis when pre-existing ones aren't available.
- Research in Drosophila embryos confirmed that even small sequence variations near DNA breaks significantly influence the repair outcomes and that specific structures, like loops, play a role in this process, highlighting the importance of sequence context in DNA repair mechanisms.
