Publications by authors named "Taylor J McColl"
Progress in physiologically based pharmacokinetic-pharmacodynamic models of amino acids in humans.
Curr Opin Clin Nutr Metab Care
November 2024
Article Synopsis
- - The review discusses the importance of amino acids for health, their roles in proteins, metabolism, and signaling, and highlights the use of physiologically based pharmacokinetic and pharmacodynamic (PBPK-PD) modeling to better understand amino acid functions.
- - Recent PBPK-PD models have provided insights into amino acid metabolism, including how leucine affects muscle protein metabolism and optimal supplementation strategies for conditions like sickle-cell disease and seizure disorders.
- - These models offer potential for future research in various areas, such as treatments for sarcopenia, comparisons between animal and plant-based nutrition, and understanding nutrient-drug interactions in diseases like Parkinson’s.
Article Synopsis
- * Researchers developed a kinetic model that integrates various cellular and physiological-level processes related to leucine metabolism and mTOR signaling in young adults' skeletal muscle.
- * The model successfully predicts outcomes from different leucine feeding protocols and highlights the importance of p70S6K levels and insulin signaling in regulating MPS and MPB, including feedback effects on mTORC1 signaling.