Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway.

Introduction: In this study, we tested the hypothesis that pre-osteoclast signaling is key in triggering post-traumatic angiogenesis in alveolar bone via the SDF-1/CXCR4 pathway. Interruption of osteoclast differentiation through zoledronate (Zol) disrupts the crosstalk between pre-osteoclasts and endothelial cells, hindering the initial angiogenic reaction following dental trauma. This disruption could therefore play a role in the pathogenesis of medication-related osteonecrosis of the jaw (MRONJ).

Effects of nutritional and hydration strategies during ultramarathon events between finishers and non-finishers: A systematic review protocol.

Ultramarathon running is a sport that is growing in popularity. Competing in an ultramarathon event is physiologically taxing on the human body, and it should not be surprising that not all individuals who enroll for an event ultimately finish. While many factors can contribute to this phenomenon, it is likely that nutritional and hydration strategies play a large role between finishing and not finishing an ultramarathon.

Comparative development of limb musculature in phylogenetically and ecologically divergent lizards.

Background: Squamate reptiles (lizards, snakes, and amphisbaenians) exhibit incredible diversity in their locomotion, behavior, morphology, and ecological breadth. Although they often are used as models of locomotor diversity, surprisingly little attention has been given to muscle development in squamate reptiles. In fact, the most detailed examination was conducted almost 80 years ago and solely focused on the proximal limb regions.

Nuclei ultrastructural changes of C6/36 cells infected with virus dengue type 2.

Introduction: Dengue virus replication has been considered mainly cytoplasmic, however, studies indicate that some flaviviruses may use the intranuclear pathway as part of the machinery that the virus uses to increase infection capacity in the host cell. This paper describes alterations at nuclear level in the cell infected with dengue, which are likely involved in the virus replication processes.

Objective: This paper addresses the ultrastructural observations of C6/36 cells of the Aedes albopictus mosquito infected with dengue virus type 2.