Suppression of microglia activation after hypoxia-ischemia results in age-dependent improvements in neurologic injury.

We previously found increased microglial proliferation and pro-inflammatory cytokine release in infant mice compared to juvenile mice after hypoxia-ischemia (HI). The aim of the current study was to assess for differences in the effect of microglial suppression on HI-induced brain injury in infant and juvenile mice. HI was induced in neonatal (P9) and juvenile (P30) mice and minocycline or vehicle was administered at 2h and 24h post-HI.

The Ohio Hospital for Epileptics-the first "epilepsy colony" in America.

This review examines the planning, development, and course of the first established colony for epilepsy in the United States-The Ohio Hospital for Epileptics. The events leading to the development of the colony, its early course, and the people who were instrumental in its establishment and maintenance are reviewed. At approximately the same time as the development of the Ohio Hospital for Epileptics, eugenics was gaining momentum in America, which affected epilepsy deeply.