Publications by authors named "Taylor Croissant"
Nucleic Acids Res
June 2018
Article Synopsis
- Overexpression of the flap endonuclease FEN1 and its homolog RAD27 in yeast leads to impaired DNA replication, causing cells to accumulate in mid-S phase.
- This overexpression results in heightened activity of checkpoint kinases and sensitivity to DNA-damaging agents, indicating a link to genome instability.
- The adverse effects of RAD27 overexpression can be mitigated by disrupting its interaction with the replication clamp PCNA, highlighting its role in replication-related damage.
