Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr mice.

Background And Aims: Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids, although overlap exists. We previously demonstrated that MΦ fatty acid transport protein 1 (FATP1, Slc27a1) was necessary to maintain the oxidative and anti-inflammatory AAM phenotype in vivo in a model of diet-induced obesity.

A framework for guiding efforts to reward value instead of volume.

The U.S. healthcare system is in the midst of a major shift from fee-for-service to value-based reimbursement models.

Parent Perceptions of Sexual Education Needs for Their Children With Autism.

Unlabelled: Primary responsibility for sexual education for adolescents with autism spectrum disorder falls on parents who have reported a lack of professional and material support. The purpose of this study was to 1) describe parent perceptions of sexual education needs of their children aged 14-20 with an autism spectrum disorder diagnosis and 2) determine parent-preferred mechanisms of delivery for tailored educational intervention strategies.

Design And Methods: The study aims were accomplished by a qualitative research design using focus groups and telephone interviews assisted by a structured interview guide.

Cation separation and preconcentration using columns containing cyclen and cyclen-resorcinarene derivatives.

The selectivity and separation of transition metal ions on two columns packed with cyclen-based macrocycles adsorbed onto 55% cross-linked styrene-divinylbenzene resin are presented. The N-cyclen and cyclen-resorcinarene stationary phases were made by adsorbing hydrophobically substituted N-cyclen or a cyclen-resorcinarene derivative (cyclenbowl) on the resin, respectively. The stability constants of cyclen with transition metal ions demonstrate that cyclen has selectivity for Cu²⁺ over other transition metal ions.

Finding the sweet spot: how to get the right staffing for variable workloads.

All too often, hospital department managers set their staff schedules too much in anticipation of high levels of demand for services, leading to higher-than-necessary staffing costs when demand is lower than expected. The opposite approach of scheduling too few staff to meet demand, then relying on on-call or callback staff to address the shortage, also results in higher-than-necessary costs due to the premium wages that such staff must be paid. A staffing and workload simulation tool allows hospital departments to find the right balance between these extremes.