Publications by authors named "Taylor Badger"
Objective: To compare in-hospital and neurodevelopmental (ND) outcomes between very preterm infants conceived spontaneously and those conceived utilizing in vitro fertilization (IVF).
Study Design: A 10-year retrospective study of a large regional, mixed urban and rural population was conducted. IVF conceived infants born <32 0/7 weeks gestational age (GA) were matched 1:2 to control patients who did not undergo any documented assisted reproductive technology (ART) based on GA, birth weight and gender.
Article Synopsis
- - Classic galactosemia (CG) is linked to mutations in the GALT gene and leads to early ovarian insufficiency (POI) in 80% of women due to a decrease in ovarian reserve, though the underlying mechanisms are still unclear.
- - This study utilized advanced techniques like single-nucleus RNA sequencing to analyze ovary biopsies from prepubertal girls with CG, revealing seven key cell types and identifying disruptions in gene expression related to stress responses and cell survival.
- - The research highlighted significant changes in signaling pathways associated with ovarian function, indicating increased cellular stress and damage in primordial follicles, which could explain accelerated follicular loss in CG patients.
Article Synopsis
- Epithelial ovarian cancer (OC) is a highly lethal cancer affecting women, with significant mortality rates and challenges in treatment due to resistance to platinum-based chemotherapy.
- The study explored the relationship between peripheral immune profiles, peritoneal microbial features, and the chemotherapy response in patients with OC, finding that inflammation levels at surgery were linked to longer disease-free intervals.
- Results indicated that unique microbial features in the peritoneal fluid could help in predicting responses to chemotherapy, though self-rated health scores did not prove to be reliable indicators of immune status in these participants.
Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs.
J Anim Sci Biotechnol
March 2020
Background: We hypothesized that supplementation of nursery and grower pig diets with coconut oil in the absence of antibiotics would yield maintenance of glucose homeostasis, growth performance, and immune function similar to what is achieved with nursery and grower pig diets containing antibiotics. Pigs received the same base treatment diets from d24 (weaning) to d71 of age and had blood and fecal samples collected on d24, d31, d45 and d71 for measurement of whole blood glucose, serum insulin, cortisol and cytokines, and fecal microbiome. Pigs had weekly weights and daily feed consumption measured throughout the study.
View Article and Find Full Text PDFEpithelial ovarian cancer (OC) is the most deadly cancer of the female reproductive system. To date, there is no effective screening method for early detection of OC and current diagnostic armamentarium may include sonographic grading of the tumor and analyzing serum levels of tumor markers, Cancer Antigen 125 (CA-125) and Human epididymis protein 4 (HE4). Microorganisms (bacterial, archaeal, and fungal cells) residing in mucosal tissues including the gastrointestinal and urogenital tracts can be altered by different disease states, and these shifts in microbial dynamics may help to diagnose disease states.
View Article and Find Full Text PDF